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Neuronal regulation from default mode network to cognitive control network

Research Project

Project/Area Number 25280052
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Cognitive science
Research InstitutionTokyo Metropolitan Institute of Medical Science

Principal Investigator

KODAMA Tohru  公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 副参事研究員 (20195746)

Co-Investigator(Kenkyū-buntansha) 田中 進  関西医科大学, 医学部, 講師 (30399472)
渡辺 正孝  公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, シニア研究員 (50092383)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2014: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2013: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Keywordsデフォルト活動 / ドーパミン / グルタミン酸 / 局所脳波活動 / 前頭前野 / 安静時脳活動 / 局所脳波 / デフォルトモード / 前頭葉 / 霊長類
Outline of Final Research Achievements

We have observed an increase in dopamine (DA) release during a working memory (WM) task compared with that during rest in the monkey lateral prefrontal cortex, but, no study has examined DA release related to the default mode of brain activity. We used a microdialysis technique to investigate changes in DA and Glutamate (Glu) releases in the medial prefrontal cortex (MPFC) during the WM task and rest. We observed a significant increase in DA release , but not in Glu release, during rest compared with that during the WM task, and interestingly an inhibitory relationship between the two transmitters in the MPFC. Considering that human default brain activity is related to internal thought processes and increased DA release in the LPFC plays an important role in executive control, increase in DA release during rest in the monkey anterior default system may be related to some form of internal thought process.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (9 results)

All 2017 2015 2014 2013 Other

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Acknowledgement Compliant: 1 results,  Open Access: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Oral Administration of Methylphenidate (Ritalin) Affects Dopamine Release Differentially Between the Prefrontal Cortex and Striatum: A Microdialysis Study in the Monkey2017

    • Author(s)
      Kodama T, Kojima T, Honda Y, Hosokawa T, Tsutsui KI, Watanabe M
    • Journal Title

      Journal of Neuroscience

      Volume: 37 Issue: 9 Pages: 2387-2394

    • DOI

      10.1523/jneurosci.2155-16.2017

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] opamine and glutamate release in the anterior default system during rest: A monkey microdialysis study.2015

    • Author(s)
      Kodama T, Hikosaka K, Honda Y, Kojima T, Tsutsui K, Watanabe M.
    • Journal Title

      Behavioral Brain Research

      Volume: 294 Pages: 194-197

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Egalitarian reward contingency in competitive games and primate prefrontal neuronal activity.2015

    • Author(s)
      Hosokawa T, Watanabe M.
    • Journal Title

      Frontier in Neuroscience

      Volume: 9 Pages: 1-10

    • DOI

      10.3389/fnins.2015.00165

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Higher dopamine release induced by less rather than more preferred reward during a working memory task in the primate prefrontal cortex.2014

    • Author(s)
      Kodama T, Hikosaka K, Honda Y, Kojima T, Watanabe M.
    • Journal Title

      Behav Brain Res.

      Volume: 266 Pages: 104-107

    • DOI

      10.1016/j.bbr.2014.02.009

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional Significance of Default Brain Activity Observed in Nonhuman Animals2013

    • Author(s)
      渡邊正孝
    • Journal Title

      Japanese Journal of Physiological Psychology and Psychophysiology

      Volume: 31 Issue: 1 Pages: 5-17

    • DOI

      10.5674/jjppp.1302si

    • NAID

      130004876232

    • ISSN
      0289-2405, 2185-551X
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Dopamine and glutamate release during resting wakefulness in the anterior default system– a monkey microdialysis study2015

    • Author(s)
      Kodama T, Honda Y, Kojima T, Watanabe M
    • Organizer
      WFSRS SLEEP2015
    • Place of Presentation
      Istanbul (Turkey)
    • Year and Date
      2015-10-31
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Default-mode brain activity and increase in dopamine release – A monkey microdialysis study in the medial prefrontal cortex

    • Author(s)
      Tohru Kodama, Kazuo Hikosaka, Yoshiko Honda, Takashi Kojima, Susumu Tanaka, Masataka Watanabe
    • Organizer
      Neuroscience2013
    • Place of Presentation
      サンディエゴ, USA
    • Related Report
      2013 Annual Research Report
  • [Book] The Prefrontal Cortex as an Executive, Emotional, and Social Brain2017

    • Author(s)
      Interaction of Dopamine and Glutamate Release in the Primate Prefrontal Cortex in Relation to Working Memory and Reward.
    • Total Pages
      20
    • Publisher
      Springer
    • Related Report
      2016 Annual Research Report
  • [Remarks]

    • URL

      http://www.igakuken.or.jp/sleep/

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2013-05-21   Modified: 2019-07-29  

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