Predicting antigenic changes of influenza viruses using text data assimilation.
| Project/Area Number |
25280080
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Intelligent informatics
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| Research Institution | Hokkaido University |
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Principal Investigator |
Kimihito Ito 北海道大学, 人獣共通感染症リサーチセンター, 教授 (60396314)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKADA Ayato 北海道大学, 人獣共通感染症リサーチセンター, 教授 (10292062)
IGARASHI Manabu 北海道大学, 人獣共通感染症リサーチセンター, 准教授 (10374240)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | インフルエンザ / 抗原変異予測 / データ同化 / ワクチン / 変異予測 / ベイズ推定 / 粒子フィルタ |
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| Outline of Final Research Achievements |
Human influenza viruses mutate from time to time, causing annual epidemics worldwide. Given the high mutation rate of the viral gene, influenza vaccine strains need to be updated every two to three years. In order to prepare an effective vaccine strain prior to each influenza season, we investigated text data assimilation methods that allow us to predict the evolution of viral amino acid sequences. As a result, we developed a mathematical model consisting of human herd immunity, the number of infections, and population of circulating vires. The model provides a mathematical basis of bioinformatics methods to prepare an effective vaccine strain prior to influenza seasons.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Interferon-Induced Transmembrane Protein-Mediated Inhibition of Host Cell Entry of Ebolaviruses2015
Author(s)
Hirohito Ogawa, Hiroko Miyamoto, Eri Nakayama, Reiko Yoshida, Ichiro Nakamura, Hirofumi Sawa, Akihiro Ishii, Yuka Thomas, Emiko Nakagawa, Keita Matsuno, Masahiro Kajihara, Junki Maruyama, Manabu Igarashi, Kimihito Ito, Ayato Takada et al
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Journal Title
J Infect Dis
Volume: jiv063
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A nairovirus isolated from African bats causes haemorrhagic gastroenteritis and severe hepatic disease in mice2014
Author(s)
Ishii A, Ueno K, Orba Y, Sasaki M, Moonga L, Hang'ombe BM, Mweene AS, Umemura T, Ito K, Hall WW, Sawa H
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Journal Title
Nat Commun
Volume: 5
Pages: 1-11
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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