Development of intraoperative rapid diagnostic imaging technology for support of breast cancer sentinel navigation surgery
| Project/Area Number |
25280103
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Life / Health / Medical informatics
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SUGAI Tamotsu 岩手医科大学, 医学部, 教授 (20187628)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Keywords | 乳がん / 化学発光 / 迅速病理診断 / センチネルリンパ節 / 免疫組織化学 / バーチャルスライド / 術中迅速診断 / 術中診断 |
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| Outline of Final Research Achievements |
Breast cancer has a high mortality rate in Japan. It is difficult to detect micro metastasis of breast cancer to lymph node, therefore intraoperative rapid diagnostic imaging technology is required for extraction of reliable cancer tissue. In this research, we studied high sensitivity breast cancer detection technology and medical image processing technology, and developed image scanning technology for intraoperative rapid pathology diagnosis. As a result of research, we developed new immunohistochemical staining technology with chemiluminescence and image scanning technology for chemiluminescence detection in pathology. We evaluated sensitivity and accuracy of our system in clinical trials, and it was more sensitive than fluorescence observation. Our technology is useful for detection of microinvasive breast cancer, and it was suggested this technology can be applied to the detection of micro metastatic cancer.
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Report
(5 results)
Research Products
(12 results)
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[Presentation] Analysis of mRNA and microRNA expression related to cell proliferation genes between crypts and stroma in human colorectal cancer2013
Author(s)
H Nozaka, A Mayama, H Takami, A Kurose, K Takahashi, Y Konishi, Y Mue, M Suzuki, N Uesugi, K Ishida, T Sugai
Organizer
The 8th Asia Pacific IAP Congress
Place of Presentation
Busan, Korea
Related Report
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