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Development of intraoperative rapid diagnostic imaging technology for support of breast cancer sentinel navigation surgery

Research Project

Project/Area Number 25280103
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Life / Health / Medical informatics
Research InstitutionHirosaki University

Principal Investigator

Nozaka Hiroyuki  弘前大学, 保健学研究科, 講師 (80302040)

Co-Investigator(Renkei-kenkyūsha) SUGAI Tamotsu  岩手医科大学, 医学部, 教授 (20187628)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Keywords乳がん / 化学発光 / 迅速病理診断 / センチネルリンパ節 / 免疫組織化学 / バーチャルスライド / 術中迅速診断 / 術中診断
Outline of Final Research Achievements

Breast cancer has a high mortality rate in Japan. It is difficult to detect micro metastasis of breast cancer to lymph node, therefore intraoperative rapid diagnostic imaging technology is required for extraction of reliable cancer tissue. In this research, we studied high sensitivity breast cancer detection technology and medical image processing technology, and developed image scanning technology for intraoperative rapid pathology diagnosis. As a result of research, we developed new immunohistochemical staining technology with chemiluminescence and image scanning technology for chemiluminescence detection in pathology. We evaluated sensitivity and accuracy of our system in clinical trials, and it was more sensitive than fluorescence observation. Our technology is useful for detection of microinvasive breast cancer, and it was suggested this technology can be applied to the detection of micro metastatic cancer.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (12 results)

All 2017 2016 2015 2014 2013 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (9 results) (of which Int'l Joint Research: 4 results) Remarks (2 results)

  • [Journal Article] Multi-Layer Virtual Slide Scanning System with Multi-Focus Image Fusion for Cytopathology and Image Diagnosis2013

    • Author(s)
      Hiroyuki NOZAKA, Tomisato MIURA, Zhongxi ZHENG
    • Journal Title

      IEICE TRANSACTIONS on Information and Systems

      Volume: Vol.E96-D No.4 Pages: 856-863

    • NAID

      10031182850

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Development of variable wavelength band-pass filter with liquid crystal for microscope2017

    • Author(s)
      Hiroyuki Nozaka
    • Organizer
      MEDLAB2017
    • Place of Presentation
      シンガポール
    • Year and Date
      2017-04-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Co-expression of HER family relates to progression and lymph node metastases in human colorectal cancer.2017

    • Author(s)
      Hiroyuki Nozaka, Miku Togashi, Sayaka Kurosawa, Ai Igarashi, Yayoi Takahashi, Makoto Eiduka, Noriyuki Uesugi, Kazuyuki Ishida, Tamotsu Sugai.
    • Organizer
      2017 United States & Canadian Academy of Pathology Annual Meeting
    • Place of Presentation
      米国 サンアントニオ
    • Year and Date
      2017-03-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 液晶波長可変フィルタによる蛍光顕微鏡システムの開発と評価2016

    • Author(s)
      野坂大喜
    • Organizer
      日本病理学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-05-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] Development of new fluorescence virtual slide system equipped with the liquid crystal filter unit.2016

    • Author(s)
      Hiroyuki Nozaka, Tomisato Miura, Zhongxi Zheng
    • Organizer
      2016 United States & Canadian Academy of Pathology Annual Meeting
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2016-03-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of fluorescence microscope system with variable wavelength band-pass filter2015

    • Author(s)
      Hiroyuki Nozaka, Tomisato Miura, Zhongxi Zheng.
    • Organizer
      Digital Pathology Congress: Asia
    • Place of Presentation
      Kuala Lumpur, Malaysia
    • Year and Date
      2015-09-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The expression of TP53 mRNA splice variants relates to progression of cancer in human colorectal cancer2014

    • Author(s)
      Hiroyuki Nozaka, Kentaro Endo, Akifumi Mayama, Kodai Takahashi, Hideki Takami, Akira Kurose, Noriyuki Uesugi, Kazuyuki Ishida, Tamotsu Sugai
    • Organizer
      IAP2014
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2014-10-07 – 2014-10-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] Analysis of mRNA and microRNA expression related to cell proliferation genes between crypts and stroma in human colorectal cancer2013

    • Author(s)
      H Nozaka, A Mayama, H Takami, A Kurose, K Takahashi, Y Konishi, Y Mue, M Suzuki, N Uesugi, K Ishida, T Sugai
    • Organizer
      The 8th Asia Pacific IAP Congress
    • Place of Presentation
      Busan, Korea
    • Related Report
      2013 Annual Research Report
  • [Presentation] Multi-layer virtual slide scanning system with multi-focus image fusion for pathology2013

    • Author(s)
      Hiroyuki Nozaka, Tomisato Miura, Zhongxi Zheng
    • Organizer
      IREMD
    • Place of Presentation
      Hirosaki, Aomori
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヒト大腸癌におけるTP53 splice variant発現解析2013

    • Author(s)
      野坂 大喜、遠藤 謙太郎、尾崎 恵理香、渡邉 純、黒瀬 顕、無江 良晴、小西 泰弘、鈴木 正通、上杉 憲幸、石田 和幸、菅井有
    • Organizer
      日本病理学会総会日本病理学会総会
    • Place of Presentation
      札幌市
    • Related Report
      2013 Annual Research Report
  • [Remarks] 弘前大学大学院保健学研究科 医用工学・医療情報工学研究室 科学研究費研究成果HP

    • URL

      http://www.mt.hirosaki-u.ac.jp/hp1/kaken.html

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
  • [Remarks] 弘前大学大学院保健学研究科 野坂研究室 科学研究費研究成果ホームページ

    • URL

      http://www.mt.hirosaki-u.ac.jp/hp/

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2013-05-21   Modified: 2019-07-29  

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