Medical informatics infrastructure for personalized genomic medicine
Project/Area Number |
25280105
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Life / Health / Medical informatics
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Research Institution | The University of Tokyo |
Principal Investigator |
Satoru Miyano 東京大学, 医科学研究所, 教授 (50128104)
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Co-Investigator(Kenkyū-buntansha) |
TOJO Arinobu 東京大学, 医科学研究所, 教授 (00211681)
FURUKAWA Yoichi 東京大学, 医科学研究所, 教授 (20272560)
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Co-Investigator(Renkei-kenkyūsha) |
YAMAGUCHI Rui 東京大学, 医科学研究所, 准教授 (90380675)
IMOTO Seiya 東京大学, 医科学研究所, 教授 (10345027)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
|
Keywords | メディカルインフォマティクス / 個別化ゲノム医療 / シリコン・シークエンサー / 消化器癌 / 血液腫瘍 / シリコンシークエンサー |
Outline of Final Research Achievements |
By utilizing the supercomputer at Human Genome Center (The University of Tokyo), we implemented a whole-genome based personalized cancer genomic medicine at the Research Hospital of the Institute of Medical Science. We employed NGS whole-genome analysis, whole-exome analysis, cancer panel, Sanger sequencing, and omics analysis including pathological data. In this process of implementation and clinical interpretation, we organized a tumor board for genomic medicine. We designed and constructed a system comprising an information infrastructure and sequencing facility of medical informatics including an application of cognitive computing technology (IBM Watson Genomic Analytics) based on biomedical big data and Clarity LIMS. In the practice of personalized cancer genomic medicine, we evaluated the usefulness of this system, and simultaneously identified challenging issues arising from whole-genome based personalized genomic medicine in addition to new discoveries in cancer research.
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] A novel mouse model of intrahepatic cholangiocarcinoma induced by liver-specific Kras activation and Pten deletion.2016
Author(s)
Ikenoue T, Terakado Y, Nakagawa H, Hikiba Y, Fujii T, Matsubara D, Noguchi R, Zhu C, Yamamoto K, Kudo Y, Asaoka Y, Yamaguchi K, Ijichi H, Tateishi K, Fukushima N, Maeda S, Koike K, Furukawa Y
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Journal Title
Sci Rep
Volume: 印刷中
Issue: 1
Pages: 23899-23899
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Molecular profiles of high-grade and low-grade pseudomyxoma peritonei.2015
Author(s)
Noguchi R, Yano H, Gohda Y, Suda R, Igari T, Ohta Y, Yamashita N, Yamaguchi K, Terakado Y, Ikenoue T, Furukawa Y
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Journal Title
Cancer Med
Volume: 4(12)
Issue: 12
Pages: 1809-1816
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Attenuated familial adenomatous polyposis with desmoids by an APC mutation2015
Author(s)
Ikenoue T, Yamaguchi K, Komura M, Imoto S, Yamaguchi R, Shimizu E, Kasuya S, Shibuya T, Hatakeyama S, Miyano S, Furukawa Y
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Journal Title
Human Genome Variation
Volume: 2
Issue: 1
Pages: 15011-15011
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Relationship between smoking and multiple colorectal cancers in patients with Japanese Lynch syndrome: a cross-sectional study conducted by the Japanese Society for Cancer of the Colon and Rectum.2015
Author(s)
Tanakaya K, Furukawa Y, Nakamura Y, Hirata K, Tomita N, Tamura K, Sugano K, Ishioka C, Yoshida T, Ishida H, Watanabe T, Sugihara K.
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Journal Title
Jpn J Clin Oncol.
Volume: 45(3)
Issue: 3
Pages: 307-310
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Detection of APC mosaicism by next-generation sequencing in an FAP patient.2015
Author(s)
Yamaguchi K, Komura M, Yamaguchi R, Imoto S, Shimizu E, Kasuya S, Shibuya T, Hatakeyama S, Takahashi N, Ikenoue T, Hata K, Tsurita G, Shinozaki M, Suzuki Y, Sugano S, Miyano S, Furukawa Y
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Journal Title
J Hum Genet
Volume: 60(5)
Issue: 5
Pages: 227-231
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Comparison of clinical features between suspected familial colorectal cancer type X and Lynch syndrome in Japanese patients with colorectal cancer:2015
Author(s)
Yamaguchi T, Furukawa Y, Nakamura Y, Matsubara N, Ishikawa H, Arai M, Tomita N, Tamura K, Sugano K, Ishioka C, Yoshida T, Moriya Y, Ishida H, Watanabe T, Sugihara K;
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Journal Title
Jpn J Clin Oncol.
Volume: 45(2)
Issue: 2
Pages: 153-159
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Global implementation of genomic medicine: We are not alone2015
Author(s)
Manolio TA, Abramowicz M, Al-Mulla F, Anderson W, (22名), Miyano S, Naparstek Y, O'Rourke PP, Patrinos GP, Rehm HL, Relling MV, Rennert G, Rodriguez LL, Roden DM, Shuldiner AR, Sinha S, Tan P, Ulfendahl M, Ward R, Williams MS, Wong JE, Green ED, Ginsburg GS
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Journal Title
Science Translational Medicine
Volume: 7(290)
Issue: 290
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Overexpression of cohesion establishment factor DSCC1 through E2F in colorectal cancer.2014
Author(s)
Yamaguchi K, Rui Yamaguchi R, Takahashi N, Ikenoue T, Fujii T, Shinozaki M, Tsurita G, Hata K, Niida A, Imoto S, Miyano S, Nakamura Y, Furukawa Y
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Journal Title
PLoS ONE
Volume: 9
Issue: 1
Pages: e85750-e85750
DOI
Related Report
Peer Reviewed
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[Journal Article] Genetic alterations in Japanese extrahepatic biliary tract cancer
Author(s)
Noguchi R, Yamaguchi K, Ikenoue T, Terakado Y, Ohta Y, Yamashita N, Kainuma O, Yokoi S, Maru Y, Nagase H, Furukawa Y. Genetic alterations in Japanese extrahepatic biliary tract cancer
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Journal Title
Oncology Letters
Volume: 印刷中
Related Report
Peer Reviewed / Open Access
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[Presentation] Cancer Genomes and Clinical Sequence2015
Author(s)
Satoru Miyano
Organizer
Princess Al Jawhara Center for Molecular Medicine: The 9th Scientific Conference
Place of Presentation
Arabic Gulf University, Manama, Bahrain
Year and Date
2015-11-28
Related Report
Int'l Joint Research / Invited
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[Presentation] がんゲノムとその未来2015
Author(s)
宮野 悟
Organizer
NPO健康医療開発機構第8回シンポジウム
Place of Presentation
学士会館(東京都千代田区)
Year and Date
2015-03-01
Related Report
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