| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
|
|---|
| Outline of Final Research Achievements |
ApcMin/+ mice develop spontaneously many intestinal adenomas and are also highly susceptible to radiation. The objective of the current projects was, by utilizing these characteristics of ApcMin/+ mice, to develop a mouse model suitable for the study of radiation-induced cancer risk at low doses and low dose rates. We explored dose rate effects and the effect of genetic background on low dose rate radiation-induced carcinogenesis. We clarified that the genetic background plays a role in dose rate effects on radiation-induced carcinogenesis. Furthermore, we developed a mouse model susceptible to radiation-induced carcinogenesis by using knockout mice that have deficient post-replication repair compared with ApcMin/+ mice.
|
