Development of mouse model susceptible to radiation-induced carcinogenesis at low dose and low dose rate and evaluation of radiation-induced cancer risk
| Project/Area Number |
25281020
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Hiroshima University |
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Principal Investigator |
Kamiya Kenji 広島大学, 原爆放射線医科学研究所, 教授 (60116564)
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| Co-Investigator(Kenkyū-buntansha) |
SASATANI MEGUMI 広島大学, 原爆放射線医科学研究所, 助教 (80423052)
IIZUKA DAISUKE 広島大学, 原爆放射線医科学研究所, 助教 (00455388)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Keywords | ゲノム障害 / ゲノム修復 / 放射線 / 発がん / 小腸腫瘍 / 突然変異 / 線量率効果 / 低線量（率） |
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| Outline of Final Research Achievements |
ApcMin/+ mice develop spontaneously many intestinal adenomas and are also highly susceptible to radiation. The objective of the current projects was, by utilizing these characteristics of ApcMin/+ mice, to develop a mouse model suitable for the study of radiation-induced cancer risk at low doses and low dose rates. We explored dose rate effects and the effect of genetic background on low dose rate radiation-induced carcinogenesis. We clarified that the genetic background plays a role in dose rate effects on radiation-induced carcinogenesis. Furthermore, we developed a mouse model susceptible to radiation-induced carcinogenesis by using knockout mice that have deficient post-replication repair compared with ApcMin/+ mice.
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Report
(4 results)
Research Products
(58 results)
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[Journal Article] Evacuation after the Great East Japan Earthquake was associated with poor dietary intake: the Fukushima Health Management Survey.2016
Author(s)
Zhang W, Ohira T, Maeda M, Yasumura S, Ohtsuru A, Harigane M, Horikoshi N, Suzuki Y, Yabe H, Yuuki M, Nagai M, Takahashi H, Nakano H, Kamiya K, Yamashita S, Abe M for the Fukushima Health Management Survey Group.
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Journal Title
J. Epidemiol.
Volume: 印刷中
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Increase in dicentric chromosome formation after a single CT scan in adults.2015
Author(s)
Abe Y, Miura T, Yoshida MA, Ujiie R, Kurosu Y, Kato N, Katafuchi A, Tsuyama N, Ohba T, Inamasu T, Shishido F, Noji H, Ogawa K, Yokouchi H, Kanazawa K, Ishida T, Muto S, Ohsugi J, Suzuki H, Ishikawa T, Kamiya K, Sakai A.
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Journal Title
Scinetific Reports
Volume: 9
Issue: 1
Pages: 13882-13882
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The Fukushima Health Management Survey: estimation of external doses to residents in Fukushima Prefecture.2015
Author(s)
Ishikawa T, Yasumura S, Ozasa K, Kobashi G, Yasuda H, Miyazaki M, Akahane K, Yonai S, Ohtsuru A, Sakai A, Sakata R, Kamiya K, Abe M
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Journal Title
Sci. Rep.
Volume: 5
Issue: 1
Pages: 12712-12712
DOI
Related Report
Peer Reviewed
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[Journal Article] RAD18 Activates the G2/M Checkpoint through DNA Damage Signaling to Maintain Genome Integrity after Ionizing Radiation Exposure.2015
Author(s)
Sasatani M, Xu Y, Kawai H, Cao L, Tateishi S, Shimura T, Li J, Iizuka D, Noda A, Hamasaki K, Kusunoki Y, Kamiya K.
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Journal Title
PLoS One
Volume: 10
Issue: 2
Pages: 1-16
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A novel ATM/TP53/p21-mediated checkpoint only activated by chronic γ-irradiation2014
Author(s)
CAO Lili, KAWAI Hidehiko, SASATANI Megumi, IIZUKA Daisuke, MASUDA Yuji, INABA Toshiya, SUZUKI Keiji, OOTSUYAMA Akira, UMATA Toshiyuki, KAMIYA Kenji, SUZUKI Fumio
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Journal Title
PLoS One
Volume: 9
Issue: 8
Pages: e104279-e104279
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] A novel interplay between the Fanconi anemia core complex and ATR-ATRIP kinase during DNA cross-link repair2013
Author(s)
J Tomida, A Itaya, T Shigechi, J Unno, E Uchida, M Ikura, Y Masuda, S Matsuda J Adachi, M Kobayashi, AR Meetei, Y Maehara, K Yamamoto K Kamiya, A Matsuura, T Matsuda. T Ikura, M Ishiai, M Takata
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Journal Title
Nucleic Acids Research
Volume: VOL. 41
Issue: 14
Pages: 6930-6941
DOI
Related Report
Peer Reviewed
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