| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2017: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Outline of Final Research Achievements |
The study confirmed the data reproducibility on a detailed analysis of site-specific gene mutagenesis using TATAM system and revealed the relationship between gene function and scrupulous gene mutagenesis involving a single DNA adduct.
Mutations have been found universally in several types of oxidative DNA adducts, studied in the TATAM system. Moreover, data indicating that even DNA adducts believed to be non-mutagenic cause infrequent mutations have emerged from analyses conducted with increased numbers of cells.
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