| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Outline of Final Research Achievements |
In this study, we found that methylmercury induced the autophagy through the function-loss of Ragulator complex which suppresses autophagy induction, but not known mechanisms. In addition, methylmercury induced the function-loss by promoting the degradation of Ragulator complex. When autophagy-related gene was inhibited by RNA interference, cultured-cells showed the methylmercury resistance. Taken together, we concluded that methylmercury might be cause the cytotoxicity through the induction of excessive autophagy.
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