Mechanism underlying the reduction of methylmercury toxicity by Ragulator complex which is an autophagy regulator
| Project/Area Number |
25281023
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Risk sciences of radiation and chemicals
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
HWANG Gi-Wook 東北大学, 薬学研究科(研究院), 准教授 (00344680)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI TSUTOMU 東北大学, 大学院薬学研究科, 助教 (00400474)
TOYAMA TAKASHI 東北大学, 大学院薬学研究科, 助教 (50720918)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
|
|---|
| Keywords | メチル水銀 / オートファジー / 毒性 |
|---|
| Outline of Final Research Achievements |
In this study, we found that methylmercury induced the autophagy through the function-loss of Ragulator complex which suppresses autophagy induction, but not known mechanisms. In addition, methylmercury induced the function-loss by promoting the degradation of Ragulator complex. When autophagy-related gene was inhibited by RNA interference, cultured-cells showed the methylmercury resistance. Taken together, we concluded that methylmercury might be cause the cytotoxicity through the induction of excessive autophagy.
|
Report
(4 results)
Research Products
(24 results)
