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Study on the effects of development exposure to organic brominated flame retardants on obesity.

Research Project

Project/Area Number 25281033
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Environmental impact assessment
Research InstitutionNational Institute for Environmental Studies

Principal Investigator

Yanagisawa Rie  国立研究開発法人国立環境研究所, 環境リスク・健康研究センター, 主任研究員 (70391167)

Co-Investigator(Kenkyū-buntansha) 小池 英子  国立研究開発法人国立環境研究所, 環境リスク・健康研究センター, 室長 (60353538)
Tin・Tin Win・Shwe (TIN・TIN Win・Shwe)  国立研究開発法人国立環境研究所, 環境健康研究センター, 主任研究員 (00391128)
Co-Investigator(Renkei-kenkyūsha) Win-Shwe Tin-Tin  国立環境研究所, 環境リスク・健康研究センター, 主任研究員 (00391128)
Project Period (FY) 2013-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Keywords肥満症 / 難燃剤 / 小児・次世代影響 / 内分泌かく乱 / 肥満 / 社会医学 / 衛生 / 環境
Outline of Final Research Achievements

Brominated flame retardants (BFRs) are widely used in many consumer products and have been found as environmental pollutants. Although BFRs can disrupt the endocrine, nervous and immune systems, the association between BFRs and obesity remains unclear. Thus, our current study investigated the effects of exposure to BFRs from fetal to adult using obese mouse model. As are results, 1) exposure to decabromodiphenyl ether (decaBDE) from childhood to adult enhanced diet-induced hyperglycemia through disruption of glucose homeostasis, 2) in utero and lactational exposure to hexabromocyclododecane (HBCD) facilitated diet-induced hyperglycemia in female offspring, but not male offspring, and 3) exposure of BFRs (decaBDE or HBCD) in the co-culture system of macrophages and adipocytes increased the production of CCL2/MCP-1 and TNF-α in a dose-dependent manner. From our study, it is suggested that exposure to low doses of BFRs may enhance obesity-related health problems

Report

(6 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (3 results)

All 2018 2016

All Presentation (3 results)

  • [Presentation] 臭素系難燃剤デカブロモジフェニルエーテルの経口曝露が肥満症に及ぼす影響2018

    • Author(s)
      柳澤利枝, 小池英子, Tin-Tin-Win-Shwe
    • Organizer
      第88回日本衛生学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヘキサブロモシクロドデカンが脂肪細胞とマクロファージによる炎症反応に及ぼす影響2016

    • Author(s)
      小池英子, 柳澤利枝, Tin Tin Win Shwe
    • Organizer
      第23回日本免疫毒性学会学術年会
    • Place of Presentation
      北九州国際会議場(福岡県)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 有機臭素系難燃剤デカブロモジフェニルエーテルが食餌性肥満に及ぼす影響2016

    • Author(s)
      柳澤利枝, 小池英子, Tin-Tin-Win-Shwe
    • Organizer
      第37回日本肥満学会
    • Place of Presentation
      東京ファッションタウンビル(東京都)
    • Related Report
      2016 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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