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Searching and risk assessment for indoor persistent chemicals -Use of companion animals as the indicators-

Research Project

Project/Area Number 25281050
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Environmental risk control and evaluation
Research InstitutionEhime University (2014-2015)
Tottori University (2013)

Principal Investigator

KUNISUE TATSUYA  愛媛大学, 沿岸環境科学研究センター, 教授 (90380287)

Co-Investigator(Kenkyū-buntansha) OKAMOTO YOSHIHARU  鳥取大学, 農学部, 教授 (50194410)
SUZUKI GO  国立研究開発法人国立環境研究所, 資源循環・廃棄物研究センター, 研究員 (70414373)
HORAI SAWAKO  鳥取大学, 地域学部, 准教授 (60512689)
Co-Investigator(Renkei-kenkyūsha) ISOBE TOMOHIKO  国立研究開発法人国立環境研究所, 環境健康研究センター, 主任研究員 (50391066)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2013: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Keywords残留性有機汚染物質 / コンパニオンアニマル / ハウスダスト / バイオアッセイ / リスク評価 / レアメタル
Outline of Final Research Achievements

Contamination status, exposure pathways, and risk assessment of persistent organic pollutants (POPs) such as polybrominated diphenyl ethers (PBDEs), personal care products (PCPs), and rare metals were studied for companion animals, pet dogs and cats, which could be useful “sentinel animals” to evaluate indoor exposure of the above chemicals for infants. The study results revealed that companion animals are exposed to POPs, PCPs, and trace elements via not only their foods but also indoor dust, and indicated that PBDE exposure might adversely affect thyroid hormone homeostasis in pet cats. The present study provided valuable scientific findings to assess the indoor environment-derived risks for companion animals, and infants investigating in the Japan Environment and Children’s Study (JECS).

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (15 results)

All 2016 2015 2014 2013

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (9 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Organohalogen compounds in pet dog and cat: Do pets biotransform natural brominated products in food to harmful hydroxlated substances?2016

    • Author(s)
      Mizukawa H, Nomiyama K, Nakatsu S, Iwata H, Yoo J, Kubota A, Yamamoto M, Ishizuka M, Ikenaka Y, Nakayama M.M.S, Kunisue T, Tanabe S
    • Journal Title

      Environmental Science & Technology

      Volume: 50 Issue: 1 Pages: 444-452

    • DOI

      10.1021/acs.est.5b04216

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Occurrence of Perchlorate and Thiocyanate in Human Serum From E-Waste Recycling and Reference Sites in Vietnam : Association With Thyroid Hormone and Iodide Levels2014

    • Author(s)
      Akifumi Eguchi, Tatsuya Kunisue, Qian Wu, Pham Thi Kim Trang, Pham Hung Viet, Kurunthachalam Kannan, Shinsuke Tanabe
    • Journal Title

      Archives of environmental contamination and toxicology

      Volume: (in press) Issue: 1 Pages: 29-41

    • DOI

      10.1007/s00244-014-0021-y

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect-based approach for hazard identification of house dust: Case studies by using in vitro bioassays detecting dioxin-like compounds, thyroid and reproductive toxicants.2014

    • Author(s)
      Suzuki, G., Tue, N.M., Takahashi, S., Tanabe, S., Sakai, S., Takigami, H.
    • Journal Title

      Current Organic Chemistry

      Volume: 18 Issue: 17 Pages: 2231-2239

    • DOI

      10.2174/1385272819666140804231453

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-surgical treatment of canine oral malignant melanoma: A case study of the application of complementary alternative medicine2014

    • Author(s)
      Itoh H, Mukaiyama T, Goto T, Hata K, Azuma K, Tsuka T, Osaki T, Imagawa T, Okamoto Y
    • Journal Title

      Oncology Letters

      Volume: 7 Issue: 6 Pages: 1829-1830

    • DOI

      10.3892/ol.2014.2041

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Toxicokinetics of dioxins and other organochlorine compounds in Japanese people: association with hepatic CYP1A2 expression level2013

    • Author(s)
      Watanabe, M. X.
    • Journal Title

      Environment International

      Volume: 53 Pages: 53-61

    • DOI

      10.1016/j.envint.2012.12.008

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Similarities in the Endocrine-Disrupting Potencies of Indoor Dust and Flame Retardants by Using Human Osteosarcoma (U2OS) Cell-Based Reporter Gene Assays2013

    • Author(s)
      Suzuki, G.
    • Journal Title

      Environmental Science and Technology

      Volume: 47 Issue: 6 Pages: 2898-2908

    • DOI

      10.1021/es304691a

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Contamination status of organohalogen compounds and their hydroxylated metabolites in pet cats: Effects on thyroid hormones homeostasis2015

    • Author(s)
      Yamamoto, Y., Nomiyama, K., Mizukawa, H., Takiguchi, M., Ishizuka, M., Kunisue, T. and Tanabe, S.
    • Organizer
      Society of Environmental Toxicology and Chemistry (SETAC) North America 36th Annual Meeting
    • Place of Presentation
      Salt Lake City, Utah, USA
    • Year and Date
      2015-11-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Contamination status of brominated flame retardants in house dust from Japan and risk assessment for humans2015

    • Author(s)
      Nishimura, R., Tue, N. M., Tanabe, S., Kunisue, T.
    • Organizer
      Society of Environmental Toxicology and Chemistry (SETAC) North America 36th Annual Meeting
    • Place of Presentation
      Salt Lake City, Utah, USA
    • Year and Date
      2015-11-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ペットネコにおける有機ハロゲン化合物および水酸化代謝物の汚染実態と甲状腺ホルモン恒常性への影響2015

    • Author(s)
      山本恭央・野見山 桂・水川葉月・滝口満喜・石塚真由美・国末達也・田辺信介
    • Organizer
      第24回環境化学討論会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 臭素系難燃剤による室内ダストの汚染とヒトの曝露量評価2015

    • Author(s)
      西村 亮・Tue, N. M.・田辺信介・国末達也
    • Organizer
      第24回環境化学討論会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] Contamination of indoor dust and exposure assessment for pet animals by personal care products2014

    • Author(s)
      Kunisue T, Ishida A, Tanoue R, Okamoto Y, Tanabe S
    • Organizer
      SETAC 35th Annual Meeting
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2014-11-09 – 2014-11-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 生活関連物質による室内ダストの汚染とペットを指標とした乳幼児への曝露評価2014

    • Author(s)
      石田明子, 田上瑠美, 岡本芳晴, 磯部友彦, 野見山桂, 田辺信介, 国末達也
    • Organizer
      第23回環境化学討論会
    • Place of Presentation
      京都大学(京都府京都市左京区吉田本町)
    • Year and Date
      2014-05-14 – 2014-05-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] イヌ・ネコにおける微量元素レベルの特性とその暴露起源の探索2014

    • Author(s)
      寳來佐和子, 中北有里子, 水川葉月, 野見山桂, 渡邉泉, 田辺信介, 岡本芳晴, 国末達也
    • Organizer
      第23回環境化学討論会
    • Place of Presentation
      京都大学(京都府京都市左京区吉田本町)
    • Year and Date
      2014-05-14 – 2014-05-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] 室内ダスト中のAR/PRアンタゴニスト及びERαアゴニストプロファイリング2013

    • Author(s)
      鈴木剛, 酒井伸一, Tue Nguyen N., 高橋真, 田辺信介, 滝上英孝
    • Organizer
      第22回環境化学討論会
    • Place of Presentation
      東京農工大学府中キャンパス(東京都府中市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 鳥取大学付属動物医療センターにおける過去3年間の胆嚢摘出術2013

    • Author(s)
      吉本佑太, 柄 武志, 東 和生, 村端悠介, 大崎智弘, 今川智敬, 岡本芳晴
    • Organizer
      平成25年度日本小動物獣医学会
    • Place of Presentation
      とりぎん文化会館(鳥取県鳥取市)
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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