| Project/Area Number |
25282020
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Toita Women’s College (2015)
Ochanomizu University (2013-2014) |
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Principal Investigator |
Otsuka Yuzuru 戸板女子短期大学, その他部局等, 教授 (20135833)
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| Co-Investigator(Kenkyū-buntansha) |
SHINDO Kazutoshi 日本女子大学, 家政学部, 教授 (80350180)
UETA Etsuko 鳥取大学, 医学部, 講師 (40335526)
NOMI Yuri 新潟薬科大学, 応用生命科学部, 助教 (20614887)
YAMAGUCHI Keiko 日本女子大学, 家政学部, 助教 (00440074)
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| Co-Investigator(Renkei-kenkyūsha) |
MIHARA Hitomi 戸板女子短期大学, 食物栄養科, 助手 (20774631)
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| Research Collaborator |
SHIBAMOTO Takayuki University of California Davis, Department of Environmental Toxicology, Distinguished Professor
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2015: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Keywords | 新規ポリフェノール / Zeylaniin A / Tram / ベトナム植物 / AGE / 抗酸化 / LC-MS/MS / 糖尿病 / エラジタンニン / 生活習慣病改善 / ベトナム食用植物 / MG-H1 / CML / 食品 / 保健機能食品 / ゼーラニンA / NR4A1 / myricitrin / 抗UV |
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| Outline of Final Research Achievements |
New polyphenol Zeylaniin A was purified from Vietnam edible plant Tram, and analyzed biological function on life style related disease. S.zeylanicum leaf was obtained from Dr. Mai of Vietnam National Nutritional Institute. Purified Zeylaniin A recovered UVA damaged cell. Zeylaniin A was added to animal feed and measured glucose and AGEs. Blood glucose of Zeylaniin A group was 320 mg/dl and showed no difference to control. New method for AGE analysis was developed with new column. Blood CEL was 73-129ng/mL and MG-H1 was 38-184ng/mL, and average of blood CEL of Zeylaniin A group was 104ng/ml. There was no significant difference between Zeylaniin A group and control group.
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