Effect of new ellagitannin, Zeylaniin A, on lifestyle related disease
| Project/Area Number |
25282020
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Toita Women’s College (2015)
Ochanomizu University (2013-2014) |
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Principal Investigator |
Otsuka Yuzuru 戸板女子短期大学, その他部局等, 教授 (20135833)
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| Co-Investigator(Kenkyū-buntansha) |
SHINDO Kazutoshi 日本女子大学, 家政学部, 教授 (80350180)
UETA Etsuko 鳥取大学, 医学部, 講師 (40335526)
NOMI Yuri 新潟薬科大学, 応用生命科学部, 助教 (20614887)
YAMAGUCHI Keiko 日本女子大学, 家政学部, 助教 (00440074)
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| Co-Investigator(Renkei-kenkyūsha) |
MIHARA Hitomi 戸板女子短期大学, 食物栄養科, 助手 (20774631)
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| Research Collaborator |
SHIBAMOTO Takayuki University of California Davis, Department of Environmental Toxicology, Distinguished Professor
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2015: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Keywords | 新規ポリフェノール / Zeylaniin A / Tram / ベトナム植物 / AGE / 抗酸化 / LC-MS/MS / 糖尿病 / エラジタンニン / 生活習慣病改善 / ベトナム食用植物 / MG-H1 / CML / 食品 / 保健機能食品 / ゼーラニンA / NR4A1 / myricitrin / 抗UV |
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| Outline of Final Research Achievements |
New polyphenol Zeylaniin A was purified from Vietnam edible plant Tram, and analyzed biological function on life style related disease. S.zeylanicum leaf was obtained from Dr. Mai of Vietnam National Nutritional Institute. Purified Zeylaniin A recovered UVA damaged cell. Zeylaniin A was added to animal feed and measured glucose and AGEs. Blood glucose of Zeylaniin A group was 320 mg/dl and showed no difference to control. New method for AGE analysis was developed with new column. Blood CEL was 73-129ng/mL and MG-H1 was 38-184ng/mL, and average of blood CEL of Zeylaniin A group was 104ng/ml. There was no significant difference between Zeylaniin A group and control group.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Efficacy of Habitual Exercise for Improving Lipid Profiles Depends on the PPRAγ Genotype in Japanese Males2014
Author(s)
Sone, Yasuko,Hirasawa, R.,Ichi, Ikuyo,Ishikawa, Tomoko,Kodama, Satoru,Sone, Hiroto,Egawa, Shigenobu,Kawahara, Kazuo,Otsuka, Yuzuru,Fujiwara, Yoko
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Journal Title
J Nutr Sci Vitaminol (Tokyo)
Volume: 60
Pages: 66-70
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Genetic Variants of the Fatty Acid Desaturase Gene Cluster Are Associated with Plasma LDL Cholesterol Levels in Japanese Males2013
Author(s)
Sone Yasuko, Kido Toshimi, Ainuki Tomomi, Sonoda Mariko, Ichi Ikuyo, Kodama Satoru, Sone Hirohito, Kondo Kazuo, Morita Yutaka, Egawa Shigenobu, Kawahara Kazuo, Otsuka Yuzuru, Fujiwara Yoko
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Journal Title
J Nutr Sci Vitaminol (Tokyo)
Volume: 59
Pages: 325-335
NAID
Related Report
Peer Reviewed
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