| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2013: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Outline of Final Research Achievements |
In this study, we identified a novel phosphorus susceptibility gene by omics analysis and elucidated the molecular basis of the mechanism, and constructed a database of developmental stage / diurnal rhythm specific phosphorus sensing. As a result, as a phosphorus-sensitive gene, AMPK and Keap 1 which is regulator of intracellular signal molecules of Nrf 2 protein, clock protein, and these circadian related genes and detoxification related genes, and the regulation of expression mechanism of FGF23 and alpha-klotho essential for phosphorus; vitamin D metabolism and vitamin D metabolism-related enzymes. In addition, we developed and established a treatment method based on the phosphorus content in the meal to prevent the onset / development of lifestyle diseases targeting developmental stage and diurnal rhythm.
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