| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2014: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2013: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Outline of Final Research Achievements |
Many nutrients are absorbed by Na-dependent transport mechanisms in the small intestine. However, little is known about how the intestine meet the needs of Na for nutrient absorption. It is thought that Na diffuses back into the lumen via paracellular pathways to support nutrient absorption. However, direct experimental evidence in support this idea has not been shown. To investigate whether paracellular pathways are involved in this Na recycling, we measured glucose-induced currents and 22Na fluxes simultaneously in Ussing chambers. We found that Na which is absorbed into enterocytes is rapidly recycled back into the lumen via paracellular pathways which are driven by increased luminal negativity.
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