Development and application of a reporter bioassay system to screen for phytochemicals mimicking the anti-aging effects of caloric restriction
| Project/Area Number |
25282027
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Waseda University |
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Principal Investigator |
CHIBA Takuya 早稲田大学, 人間科学学術院, 教授 (40336152)
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| Co-Investigator(Kenkyū-buntansha) |
HIGUCHI Keiichi 信州大学, 医学(系)研究科, 教授 (20173156)
NISHIZONO Shoko 崇城大学, 生物生命学部, 准教授 (40336970)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2013: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | 老化 / カロリー制限 / 酸化ストレス / 脂質代謝 / 機能性食品 / 転写因子 / がん / 生活習慣病 / インスリンシグナル / 老化関連疾患 / ポリフェノール / 食品化学 / トランスジェニックマウス / 代謝 / 食品成分 / ガン / 栄養科学 |
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| Outline of Final Research Achievements |
Caloric restriction (CR) without malnutrition in normal mice, and suppression of the GH/IGF-I axis in spontaneous mutant Ames dwarf (DF) mice, extend lifespan and delay the onset of various age-dependent disorders. Combined, these two lifespan-prolonging interventions have an additive effect in DF mice. We aimed to identity the intracellular signaling pathways mediating these effects, and to develop a system to screen anti-aging phytochemicals both in vitro and in vivo. We identified HNF-4 alpha and Nrf2, important transcription factors involved in glucose and lipid metabolism and oxidative stress resistance, respectively, might critical regulators for longevity gene regulations. We also found that taurine could mimic the anti-aging effects such as increased oxidative stress resistance. These results indicate that our bioassay system would be useful to screen for chemicals, which mimic the beneficial effects of CR without actual food restriction.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Overexpression of the adiponectin gene mimics the metabolic and stress resistance effects of calorie restriction, but not the anti-tumor effect2015
Author(s)
Kamohara R, Yamaza H, Tsuchiya T, Komatsu T, Park S, Hayashi H, Chiba T, Mori R, Otabe S, Yamada K, Nagayasu T, Shimokawa I
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Journal Title
Experimental Gerontology
Volume: 64
Pages: 46-54
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Chronological analysis of caloric restriction-induced alteration of fatty acid biosynthesis in white adipose tissue of rats.2015
Author(s)
Naoyuki Okita, Takuro Tsuchiya, Mayumi Fukushima, Kaho Itakura, Keiko Yuguchi, Takumi Narita, Yukari Hashizume, Yuka Sudo, Takuya Chiba, Isao Shimokawa, Yoshikazu Higami,
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Journal Title
EXPERIMENTAL GERONTOLOGY
Volume: 63
Pages: 59-66
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A key role for neuropeptide Y in lifespan extension and cancer suppression via dietary restriction2014
Author(s)
Chiba T, Tamashiro Y, Park D, Kusudo T, Fujie R, Komatsu T, Kim SE, Park S, Hayashi H, Mori R, Yamashita H, Chung HY, Shimokawa I.
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Journal Title
Sci Rep
Volume: 4
Issue: 1
Pages: 4517-4517
DOI
NAID
Related Report
Peer Reviewed / Open Access
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