| Project/Area Number |
25282126
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIURA HIDEKAZU 東北大学, 加齢医学研究所, 助教 (50451894)
YAMBE TOMOYUKI 東北大学, 加齢医学研究所, 教授 (70241578)
SASAKI KAZUMASU 東北大学, 加齢医学研究所, 助教 (80738948)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAGISHI MASAAKI 京都府立医科大学, 小児心臓血管外科, 教授 (40182422)
AKIYAMA MASATOSHI 東北大学, 心臓血管外科, 講師 (80526450)
SAIKI YOSHIKATSU 東北大学, 心臓血管外科, 教授 (50372298)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2013: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Keywords | 先天性心疾患 / 人工心筋 / 形状記憶合金線維 / マイクロマシン / 循環器・高血圧 |
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| Outline of Final Research Achievements |
Long-term mechanical support systems development resources are needed for the surgical treatment of congenital heart failure. We employed a small-sized nano-tech Ni-Ti shape memory alloy fibre as an implantable actuator for the mechanical circulatory support. We focused on the development of two types of implantable devices; a) a right ventricular external contraction support belt, and b) a Fontan circulation active support system that could be used with the total cavopulmonary connection. We examined the systems function in the originally designed mock circulatory system with a silicone-rubber right ventricular model as well as in the animal models. As a result of this study, it was indicated that the micro actuation system for congenital heart failure support could be useful to exhibit the hemodynamic effect for the totally implantable system design.
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