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Development and evaluation of neural-tissue-penetrating carbon-nanotube-bundle electrodes towards implant applications

Research Project

Project/Area Number 25282130
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionOsaka University

Principal Investigator

Hayashida Yuki  大阪大学, 工学研究科, 准教授 (10381005)

Co-Investigator(Renkei-kenkyūsha) KAMEDA Seiji  大阪大学, 国際医工情報センター, 特任准教授 (80542282)
SUEMATSU Naofumi  大阪大学, 大学院工学研究科, 准教授 (30779517)
TETSUYA Yagi  大阪大学, 大学院工学研究科, 教授 (50183976)
Research Collaborator YAMAKAWA Takahiro  
IIZUKA Seita  
SAKATA Yuya  
OTA Rira  
TANAKA Yuta  
UMEHIRA Yuichi  
NOMOTO Tomohiro  
SUGA Shohei  
Project Period (FY) 2013-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2013: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Keywords生物・生体工学 / ナノ材料 / 脳・神経 / 神経電極 / 神経刺激 / 神経補綴 / 神経工学 / 神経生理学
Outline of Final Research Achievements

We modified and improved our previously developed carbon-nanotube-bundle neural electrodes towards the implant application, and evaluated their performances in brain tissues by means of physiological experiments in vivo, and of others. As a result, we succeeded in fabricating CNTb electrodes having mechanical strength, shape, and electrochemical properties usable for insertion into, and the microstimulation in, the cerebral cortex of rodents in vivo. Furthermore, by millisecond resolution in-vivo imaging of the cortical activity, we demonstrated that the microstimulation through our CNTb electrodes can artificially induce neural excitations. We believe these unprecedented results will greatly expand the potential of neural prostheses with next-generation multi-channel stimulation.

Report

(6 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (75 results)

All 2018 2017 2016 2015 2014 2013 Other

All Int'l Joint Research (4 results) Journal Article (13 results) (of which Peer Reviewed: 13 results,  Open Access: 1 results,  Acknowledgement Compliant: 2 results) Presentation (54 results) (of which Int'l Joint Research: 12 results,  Invited: 6 results) Remarks (4 results)

  • [Int'l Joint Research] Shanghai Jiao Tong University(China)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University of New South Wales(Australia)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Professor Gregg Suaning/Biomedical Engineering/University of New South Wales(Australia)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Age-related changes in the spatiotemporal responses to electrical stimulation in the visual cortex of rats with progressive vision loss2017

    • Author(s)
      S. Miyamoto, N. Suematsu, Y. Umehira , Y. Hayashida, T. Yagi
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 14165-14165

    • DOI

      10.1038/s41598-017-14303-1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Retinal circuit emulator with spatio-temporal spike outputs at milliseconds resolution in response to visual events2017

    • Author(s)
      Yuki Hayashida, Yuka Kudo, Ryoya Ishida, Hirotsugu Okuno, Tetsuya Yagi
    • Journal Title

      IEEE Transactions on biomedical circuits and systems

      Volume: 11 Issue: 3 Pages: 597-611

    • DOI

      10.1109/tbcas.2017.2662659

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Local inhibition of microstimulation-induced neural excitations by near-infrared laser irradiation in mouse cerebral slices in vitro2017

    • Author(s)
      Yuki Hayashida, Yuya Sakata, Yuta Tanaka, Tomohiro Nomoto, Tetsuya Yagi
    • Journal Title

      Conference Proceedings of 2017 8th International IEEE/EMBS Conference on Neural Engineering (NER)

      Volume: - Pages: 255-258

    • DOI

      10.1109/ner.2017.8008339

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Imaging of population spikes induced by repetitive stimulus pulses in mouse cerebral slices in vitro2017

    • Author(s)
      Tomohiro Nomoto, Yuta Tanaka, Yuki Hayashida, Tetsuya Yagi
    • Journal Title

      Conference Proceedings of 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

      Volume: - Pages: 1109-1109

    • DOI

      10.1109/embc.2017.8037022

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Local inhibition of microstimulation-induced neural excitations by near-infrared laser irradiation in mouse cerebral slices in vitro2017

    • Author(s)
      Yuki Hayashida, Yuya Sakata, Yuta Tanaka, Tomohiro Nomoto, Tetsuya Yagi
    • Journal Title

      Conf. Proc. IEEE/EMBS Neural Eng.

      Volume: -

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A Programmable Controller for Spatio-temporal Pattern Stimulation of Cortical Visual Prosthesis2016

    • Author(s)
      Tomoki Sugiura, Arif Ullah Khan, Jaehoon Yu, Yoshinori Takeuchi, Seiji Kameda, Takatsugu Kamata, Yuki Hayashida, Tetsuya Yagi , Masaharu Imai
    • Journal Title

      Conf. Proc. IEEE Biomed. Circuits Syst.

      Volume: - Pages: 432-435

    • DOI

      10.1109/biocas.2016.7833824

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A retino-morphic hardware system simulating the graded and action potentials in retinal neuronal layers2016

    • Author(s)
      Yuka Kudo, Yuki Hayashida, Ryoya Ishida, Hirotsugu Okuno, Tetsuya Yagi
    • Journal Title

      Lecture Notes in Computer Science

      Volume: 9948 Pages: 326-333

    • DOI

      10.1007/978-3-319-46672-9_37

    • ISBN
      9783319466712, 9783319466729
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cortical neural excitations in rats in vivo with using a prototype of a wireless multi-channel microstimulation system2015

    • Author(s)
      Y. Hayashida, Y. Umehira, K. Takatani, S. Futami, S. Kameda, T. Kamata, A. U. Khan, Y. Takeuchi, M. Imai,and T. Yagi
    • Journal Title

      Conf. Proc. IEEE Eng. Med. Biol. Soc.

      Volume: n.a. Pages: 1642-1645

    • DOI

      10.1109/embc.2015.7318690

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A large scale simulation of excitation propagation in layer 2/3 of primary and secondary visual cortices of mice2015

    • Author(s)
      Ohtsu, T. Nomura, S. Uno, K. Maeda, Y. Hayashida, T. Yagi
    • Journal Title

      Conf. Proc. IEEE Eng. Med. Biol. Soc.

      Volume: n.a. Pages: 3957-3960

    • DOI

      10.1109/embc.2015.7319260

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Multi-channel Current Stimulator Chip for High Impedance Neural Electrodes2014

    • Author(s)
      亀田成司,林田祐樹,田中宏喜,八木哲也
    • Journal Title

      Transactions of the Society of Instrument and Control Engineers

      Volume: 50 Issue: 8 Pages: 594-601

    • DOI

      10.9746/sicetr.50.594

    • NAID

      130004679651

    • ISSN
      0453-4654, 1883-8189
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Voltage-sensitive dye imaging of the visual cortices responding to electrical pulses at different intervals in mice in vivo.2014

    • Author(s)
      Hayashida Y, Takeuchi K, Ishikawa N, Okazaki Y, Tamas F, Tanaka H, Yagi T.
    • Journal Title

      Conference Proceedings of IEEE Engineering in Medicine and Biology Society

      Volume: n.a. Pages: 402-405

    • DOI

      10.1109/embc.2014.6943613

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A multichannel current stimulator chip for spatiotemporal pattern stimulation of neural tissues.2014

    • Author(s)
      Kameda S, Hayashida Y, Tanaka Y, Akita D, Yagi T.
    • Journal Title

      Conference Proceedings of IEEE Engineering in Medicine and Biology Society

      Volume: n.a. Pages: 5011-5015

    • DOI

      10.1109/embc.2014.6944750

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interfacing neurons through the patch membrane pierced with single-walled carbon nanotubes.2013

    • Author(s)
      Y. Hayashida, T. Kinoshita, T. Motomura
    • Journal Title

      Conference Proceedings of the IEEE Engineering in Medicine and Biological Society

      Volume: n.a. Pages: 4502-4505

    • DOI

      10.1109/embc.2013.6610547

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Voltage-Sensitive Dye Neural Imaging for Testing and Designing Stimuli in Visual Prostheses2018

    • Author(s)
      Yuki Hayashida
    • Organizer
      2018 40th Annual International conference of the IEEE, Engineering in Medicine and Biology Society (EMBC2018), Hawaii, USA, July 17-21 (Accepted)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ハードウェアモデルによる網膜神経節細胞スパイクの画像特徴抽出の解析2018

    • Author(s)
      石井孝治, 山口弘嗣, 林田祐樹, 末松尚史, 八木哲也
    • Organizer
      電子情報通信学会 ニューロコンピューティング研究会, 東京, 3月13-14日
    • Related Report
      2017 Annual Research Report
  • [Presentation] マウス網膜神経節細胞の高頻度スパイク集団による視覚情報抽出2018

    • Author(s)
      山口弘嗣, 工藤有華, 石井孝治, 林田祐樹, 八木哲也
    • Organizer
      電子情報通信学会 ニューロコンピューティング研究会, 福岡, 1月26日
    • Related Report
      2017 Annual Research Report
  • [Presentation] Intra-cortical neural stimulator for sensory prostheses2017

    • Author(s)
      Yuki Hayashida, Yuichi. Umehira, Hirosumi Yamazaki, Tetsuya. Yagi
    • Organizer
      The 5th RIEC International Symposium on Brain Functions and Brain Computer
    • Place of Presentation
      Tohoku University, Sendai
    • Year and Date
      2017-02-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Wireless device system for multi-channel intra-cortical microstimulations ~Evaluation with animal studies in vivo2017

    • Author(s)
      Yuki Hayashida
    • Organizer
      2017 39th Annual International conference of the IEEE, Engineering in Medicine and Biology Society (EMBC2017), Jeju, Korea, July 11-17
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Optical-electrical modulation of cortical neuronal activities in the perfused tissue slice2017

    • Author(s)
      Yuki Hayashida, Yuya Sakata, Yuta Tanaka, Tomohiro Nomoto, Tetsuya Yagi
    • Organizer
      The 7th International Multidisciplinary Conference on Optofluidics 2017, Singapore, July 25-28
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Quantitative Characterization of Neural Responses Induced by Microstimulation in Mice Visual Cortex for Designing a Visual Prosthetic Stimulation2017

    • Author(s)
      Naofumi Suematsu, Koki Takatani, Yuki Hayashida, Yuka Okazaki, Tetsuya Yagi
    • Organizer
      The Eye and The Chip 2017, Detroit, US, September 24-26,
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脳皮質内刺激型の視覚補綴へ向けたシステム開発と基礎研究2017

    • Author(s)
      林田祐樹
    • Organizer
      電子情報通信学会 MEとバイオサイバネティクス研究会, 大阪, 10月7日
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Millisecond-scale imaging of population spikes and the subsequent trans-synaptic excitations induced by microstimulation pulses in mouse cerebral slices2017

    • Author(s)
      Yuki Hayashida, Yuta Tanaka, Tomohiro Nomoto, Yuya Sakata, Tetsuya Yagi
    • Organizer
      第40回 日本神経科学大会, 千葉, 7月20-23日
    • Related Report
      2017 Annual Research Report
  • [Presentation] マウス視覚野における集合活動電位発火の誘発 - 皮質内電流刺激パラメータの検討2017

    • Author(s)
      野本知宏, 田中雄太, 林田祐樹, 八木哲也
    • Organizer
      電気学会 電子・情報・システム部門(C部門)大会, 香川, 9月6-8日
    • Related Report
      2017 Annual Research Report
  • [Presentation] VRハードウェア実装に向けた脳刺激型人工視覚の定式化シミュレーションモデルの検討"2017

    • Author(s)
      岸上展章, 崔軫煥, 戸田敦士, 林田祐樹, 八木哲也
    • Organizer
      計測自動制御学会 ライフエンジニアリング部門シンポジウム, 岐阜, 9月4-6日
    • Related Report
      2017 Annual Research Report
  • [Presentation] 背景光によるマウス網膜神経節細胞の光応答特性の変化2017

    • Author(s)
      塩田憲史, 鳴戸夕貴, 柏木雄毅, 末松尚史, 八木哲也, 林田祐樹
    • Organizer
      電子情報通信学会 MEとバイオサイバネティクス研究会, 大阪, 10月7日
    • Related Report
      2017 Annual Research Report
  • [Presentation] 光刺激に対するマウス両脳視覚野における時空間的神経応答のイメージング解析2017

    • Author(s)
      清藤園未, 二見成俊, 末松尚史, 林田祐樹, 八木哲也
    • Organizer
      電子情報通信学会 MEとバイオサイバネティクス研究会, 大阪, 10月7日
    • Related Report
      2017 Annual Research Report
  • [Presentation] in-vivoマウス視覚野における微小電流刺激に誘発されるシナプス性興奮伝播のメカニズムに関する考察 (MEとバイオサイバネティックス研究専門委員会研究奨励賞 受賞)2017

    • Author(s)
      森定慶祐, 柿市峻佑, 末松尚史, 林田祐樹, 八木哲也
    • Organizer
      電子情報通信学会 MEとバイオサイバネティクス研究会, 大阪, 10月7日
    • Related Report
      2017 Annual Research Report
  • [Presentation] 皮質内刺激型視覚補綴に向けた有効刺激パラメータの検討~脳切片試料における集合活動電位応答のイメージング解析2017

    • Author(s)
      林田祐樹, 野本知宏, 田中雄太, 梅比良裕一, 亀田成司, 八木哲也
    • Organizer
      視覚科学フォーラム2017豊橋 第21回研究会, 愛知, 9月28-29日
    • Related Report
      2017 Annual Research Report
  • [Presentation] Spatiotemporal excitation of the primary visual cortex induced by intracortical microstimulation in the Royal College of Surgeons rats2016

    • Author(s)
      Soshi Miyamoto, Naofumi Suematsu, Yuichi Umehira, Yuki Hayashida, Tetsuya Yagi,
    • Organizer
      Society for Neuroscience 46th Annual Meeting Neuroscience 2016
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Response profiles of a neuronal population excited by intracortical microstimulations in the mouse visual cortex2016

    • Author(s)
      Naofumi Suematsu, Koki Takatani, Yuki Hayashida, Yuka Okazaki, Tetsuya Yagi
    • Organizer
      Society for Neuroscience 46th Annual Meeting Neuroscience 2016
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脳刺激型人工視覚2016

    • Author(s)
      林田祐樹
    • Organizer
      SICEライフエンジニアリング部門シンポジウム2016 (第31回生体・生理工学シンポジウム)
    • Place of Presentation
      大阪国際交流センター、大阪
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] A Low Energy Implementation of Neural Stimulation Microprocessor for Cortical Visual Prothesis2016

    • Author(s)
      Tomoki Sugiura, Jaehoon Yu, Yoshinori Takeuchi, Yuki Hayashida, Tetsuya Yagi , Masaharu Imai
    • Organizer
      The 1st IEEE BrainCAS workshop
    • Place of Presentation
      Hangzhou, China
    • Year and Date
      2016-10-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Multi-channel microstimulation system applicable for in-vivo animal experiments on neural prostheses2016

    • Author(s)
      Yuki Hayashida
    • Organizer
      2016 Biomedical Engineering Ecosystem Symposium
    • Place of Presentation
      Tainan, Taiwan
    • Year and Date
      2016-10-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 脳刺激型人工視覚のための集積多チャネル刺激チップ開発とその応用2016

    • Author(s)
      梅比良裕一、林田祐樹、亀田成司、鎌田隆嗣、八木哲也
    • Organizer
      視覚科学フォーラム第20回研究会
    • Place of Presentation
      大阪大学、大阪
    • Year and Date
      2016-08-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 網膜機能シミュレータの開発:仮想in vivo実験に向けて2016

    • Author(s)
      工藤有華、林田祐樹、木虎秀二、長谷川潤、八木哲也
    • Organizer
      視覚科学フォーラム第20回研究会
    • Place of Presentation
      大阪大学、大阪
    • Year and Date
      2016-08-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] Imaging studies on visual cortical responses to microstimulation in rodents, and prototyping the prosthetic device for animals2016

    • Author(s)
      Yuki Hayashida
    • Organizer
      The 6th International Multidisciplinary Conference on Optofluidics (Optofluidcs2016)
    • Place of Presentation
      Beijing, China
    • Year and Date
      2016-07-24
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Neural response profiles measured with an implantable multichannel stimulator in the rat visual cortex2016

    • Author(s)
      Yuichi Umehira, Yuki Hayashida, Seiji Kameda, Takatsugu Kamata, Tetsuya Yagi:
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Cell-attached recordings of light-induced postsynaptic potentials in mouse retinal ganglion cells2016

    • Author(s)
      Shuji Kitora, Tetsuya Yagi, Yuki Hayashida
    • Organizer
      Society for Neuroscience 46th Annual Meeting Neuroscience 2016
    • Place of Presentation
      San Diego, USA
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 膜電位応答イメージングによる皮質内微小電流刺激のパラメータの検討2016

    • Author(s)
      野本知宏、田中雄太、林田祐樹、八木哲也
    • Organizer
      電子情報通信学会MEとバイオサイバネティクス研究会(2016年10月)
    • Place of Presentation
      大阪電気通信大学、寝屋川
    • Related Report
      2016 Annual Research Report
  • [Presentation] 信号伝達の収斂・発散を考慮したマウス網膜一過性Off-α型神経節細胞応答のシミュレーション2016

    • Author(s)
      山口弘嗣、工藤有華、木虎秀二、山内翔太、林田祐樹、八木哲也
    • Organizer
      電子情報通信学会MEとバイオサイバネティクス研究会(2016年10月)
    • Place of Presentation
      大阪電気通信大学、寝屋川
    • Related Report
      2016 Annual Research Report
  • [Presentation] 大脳皮質内多チャンネル微小刺激による人工感覚補綴に向けた基礎研究2015

    • Author(s)
      林田祐樹, 梅比良裕一, 亀田成司, 鎌田隆嗣, 武内良典, 今井正治, 八木哲也
    • Organizer
      第58回自動制御連合講演会
    • Place of Presentation
      神戸大学,兵庫県神戸市
    • Year and Date
      2015-11-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] サンショウウオ網膜におけるスパイク発火潜時による明暗符号化に関するシミュレーション解析2015

    • Author(s)
      工藤有華, 林田祐樹, 石田椋也, 山内翔太, 奥野弘嗣, 八木哲也
    • Organizer
      電子情報通信学会 MEとバイオサイバネティクス研究会(2015年10月)
    • Place of Presentation
      大阪電気通信大学,大阪府寝屋川市
    • Year and Date
      2015-10-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] 多チャンネル刺激用VLSIチップを用いたin-vivoラット皮質内微小電流刺激の検討2015

    • Author(s)
      梅比良裕一, 林田祐樹, 二見成俊, 高谷光基, 亀田成司, 八木哲也
    • Organizer
      電子情報通信学会 MEとバイオサイバネティクス研究会(2015年10月)
    • Place of Presentation
      大阪電気通信大学,大阪府寝屋川市
    • Year and Date
      2015-10-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] Spatio-temporal imaging analysis on action potential initiations in the mouse cerebral cortex responding to electrical single-pulse microstimulations2015

    • Author(s)
      Y. Tanaka, Y. Hayashida, Y. Sakata, T. Yagi
    • Organizer
      計測自動制御学会 ライフエンジニアリング部門シンポジウム2015
    • Place of Presentation
      九州工業大学,福岡県飯塚市
    • Year and Date
      2015-09-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] Inter-hemispheric neural excitations of visual cortices in response to electrical microstimuli in mice in vivo2015

    • Author(s)
      S. Futami, T. Fehervari, T. Yagi, Y. Hayashida
    • Organizer
      Engineering in Medicine and Biology Society (EMBC), 2015 37th Annual International conference of the IEEE
    • Place of Presentation
      Milan, Italy
    • Year and Date
      2015-08-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A multi-functional microprocessor-controlled VLSI System-on-a-Chip useful for neural prostheses with a wireless communication and a power transmission2015

    • Author(s)
      T. Kamata, Y. Takeuchi, A. U. Khan, J. Yu, S. Kameda, Y. Hayashida, M. Imai, T. Yagi
    • Organizer
      The 38th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      神戸国際会議場,兵庫県神戸市
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Voltage imaging of the signal propagations induced by electrical stimuli to the contralateral visual cortex in mice in vivo2015

    • Author(s)
      Y. Hayashida, S. Futami, T. Yagi
    • Organizer
      The 38th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      神戸国際会議場,兵庫県神戸市
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Interaction between neuronal responses to multi-site microstimulation in the mouse visual cortices in vivo.2015

    • Author(s)
      Y. Hayashida, K. Takatani, S. Yamaguchi, K. Takeuchi, Y. Okazaki, T. Yagi.
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      神戸国際会議場・展示場,神戸市
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 皮質内微小電気刺激に対する神経興奮範囲の膜電位イメージング2015

    • Author(s)
      田中雄太,林田祐樹,八木哲也
    • Organizer
      電子情報通信学会MEとバイオサイバネティクス研究会(2014年3月)
    • Place of Presentation
      玉川大学,町田市
    • Year and Date
      2015-03-16 – 2015-03-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] 視覚皮質補綴に向けた時空間パターン刺激チップの試作2015

    • Author(s)
      亀田成司,林田祐樹,八木哲也
    • Organizer
      電子情報通信学会2015年総合大会
    • Place of Presentation
      立命館大学びわこ・くさつキャンパス,草津市
    • Year and Date
      2015-03-10 – 2015-03-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] マウス網膜神経節細胞の線形応答特性に関する実験解析2015

    • Author(s)
      鳴戸夕貴,八木哲也,林田祐樹
    • Organizer
      電子情報通信学会MEとバイオサイバネティクス研究会(2014年1月)
    • Place of Presentation
      熊本大学,熊本市
    • Year and Date
      2015-01-22 – 2025-01-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 膜電位感受性色素を用いたマウス左右大脳皮質間における信号伝達のin-vivoイメージング2015

    • Author(s)
      二見成俊,林田祐樹,八木哲也
    • Organizer
      電子情報通信学会MEとバイオサイバネティクス研究会(2014年1月)
    • Place of Presentation
      熊本大学,熊本市
    • Year and Date
      2015-01-22 – 2015-01-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] マウス大脳視覚野における多点電極刺激に対する時空間神経応答のin-vivoイメージング解析2015

    • Author(s)
      高谷光基,林田祐樹,竹内浩造,山口俊平,岡崎祐香,八木哲也
    • Organizer
      電子情報通信学会MEとバイオサイバネティクス研究会(2014年1月)
    • Place of Presentation
      熊本大学,熊本市
    • Year and Date
      2015-01-22 – 2015-01-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Inhibitory effect of near-infrared laser irradiation on neurons in the cerebral slice of genetically unmodified mice2014

    • Author(s)
      Y. Hayashida, Y. Sakata, T. Yagi
    • Organizer
      計測自動制御学会ライフエンジニアリング部門シンポジウム2014
    • Place of Presentation
      金沢大学,金沢市
    • Year and Date
      2014-09-17 – 2014-09-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Prototyping and Testing of a VLSI Chip for Spatiotemporal Pattern Stimulation in Visual Cortical Prostheses2014

    • Author(s)
      S. Kameda, Y. Hayashida, T. Yagi
    • Organizer
      計測自動制御学会ライフエンジニアリング部門シンポジウム2014
    • Place of Presentation
      金沢大学,金沢市
    • Year and Date
      2014-09-17 – 2014-09-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] A Multi-channel Stimulation System with Wireless Communication and Power Transmission for Visual Cortical Prostheses2014

    • Author(s)
      S. Kameda, T. Kamata, Y. Hayashida, M. Imai, Y. Takeuchi, T. Yagi
    • Organizer
      第37回日本神経科学大会 (Neuroscience 2014)
    • Place of Presentation
      パシフィコ横浜,横浜市
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Voltage-sensitive dye imaging of the visual cortices responding to electrical pulses at different intervals in mice in vivo.2014

    • Author(s)
      Hayashida Y, Takeuchi K, Ishikawa N, Okazaki Y, Tamas F, Tanaka H, Yagi T.
    • Organizer
      36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Chicago, U.S.A.
    • Year and Date
      2014-08-26 – 2014-08-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] A multichannel current stimulator chip for spatiotemporal pattern stimulation of neural tissues.2014

    • Author(s)
      Kameda S, Hayashida Y, Tanaka Y, Akita D, Yagi T.
    • Organizer
      36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Chicago, U.S.A.
    • Year and Date
      2014-08-26 – 2014-08-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] Microstimulation for visual prosthetic interfaces2014

    • Author(s)
      Y. Hayashida, S. Kameda, N. Ishikawa, K. Takeuchi, H. Tanaka, Y. Okazaki
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島県鹿児島市
    • Related Report
      2013 Annual Research Report
  • [Presentation] マウス視覚野V1電気刺激に惹起される応答の領野内及び領野間伝播特性2014

    • Author(s)
      竹内浩造,林田祐樹,石川直裕,田中宏喜,Tamas Fehervari,岡崎祐香,八木哲也
    • Organizer
      電子情報通信学会MEとバイオサイバネティクス研究会(2014年3月)
    • Place of Presentation
      東京都町田市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 皮質1次視覚野における広域水平信号伝播の生理学シミュレーション2014

    • Author(s)
      烏野翔太,津崎圭亮,林田祐樹,八木哲也
    • Organizer
      電子情報通信学会ニューロコンピューティング研究会(2014年3月)
    • Place of Presentation
      東京都町田市
    • Related Report
      2013 Annual Research Report
  • [Presentation] A multi-channel current stimulator chip intended for a visual cortical implant2013

    • Author(s)
      S. Kameda, Y. Hayashida, H. Tanaka, D. Akita, A. Iwata, T. Yagi
    • Organizer
      35th Annual International Conference of the IEEE Engineering in Medicine and Biological Society
    • Place of Presentation
      Osaka, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] Interfacing neurons through the patch membrane pierced with single-walled carbon nanotubes2013

    • Author(s)
      Y. Hayashida, T. Kinoshita, T. Motomura
    • Organizer
      35th Annual International Conference of the IEEE Engineering in Medicine and Biological Society
    • Place of Presentation
      Osaka, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] マウス視覚野V1電気刺激に惹起される応答の領野内及び領野間伝播特性2013

    • Author(s)
      竹内浩造,林田祐樹,石川直裕,田中宏喜,Tamas Fehervari,岡崎祐香,八木哲也
    • Organizer
      第17回視覚科学フォーラム
    • Place of Presentation
      滋賀県草津市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 多チャンネル電流パルス刺激チップの試作と評価2013

    • Author(s)
      亀田成司,林田祐樹,田中宏喜,秋田大,八木哲也
    • Organizer
      平成25年電気学会電子・情報・システム部門大会
    • Place of Presentation
      北海道北見市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Neural micro-stimulations for brain interface ~Millisecond imaging of neural responses in the mouse visual cortex~2013

    • Author(s)
      Y. Hayashida, T. Kozuno, K. Takeuchi, Y. Sakata, Y. Shimada, T. Yagi
    • Organizer
      ライフエンジニアリング部門シンポジウム2013
    • Place of Presentation
      神奈川県横浜市
    • Related Report
      2013 Annual Research Report
  • [Presentation] A multi-channel current-pulse generator chip used for high impedance stimulating electrodes2013

    • Author(s)
      S. Kameda, Y. Hayashida, H. Tanaka, D. Akita, T. Yagi
    • Organizer
      ライフエンジニアリング部門シンポジウム2013
    • Place of Presentation
      神奈川県横浜市
    • Related Report
      2013 Annual Research Report
  • [Remarks] 生体システムデバイス領域 :研究内容

    • URL

      http://neuron.eei.eng.osaka-u.ac.jp/reserch.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] BioSystems and Devices Area: Research

    • URL

      http://neuron.eei.eng.osaka-u.ac.jp/reserch_en.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 大阪大学 大学院工学研究科 電気電子情報工学専攻 電子工学部門 生体システムデバイス領域ー研究内容

    • URL

      http://neuron.eei.eng.osaka-u.ac.jp/reserch.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] Neural Interface with Defined Microstimulations

    • URL

      http://neuron.eei.eng.osaka-u.ac.jp/reserch_en.html

    • Related Report
      2015 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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