| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
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| Outline of Final Research Achievements |
Two kinds of stem cell-based self-assembled tissues (SATs) were produced through either a cell culture of mesenchymal stem cell (MSC) on a nano-periodic-structured surface (nano-SAT) or a cell culture of MSC on nano-collagen fibers (fiber-SAT). Both the STAs exhibited more complicated fiber-reinforced structure with stiffer and stronger properties than normal SAT. Then, either of the nano-SAT or the fiber-SAT was implanted into partial chondro-defects of rabbit femoral cartilage. At 3 months after implantation, the repair tissues exhibited well-organized cartilage-like structures with abundant type-II collagen. In particular, tissues repaired with the fiber-SAT exhibited a low coefficient of friction with a small variation. In addition, we found that the fiber-SAT had a significant property for the repair of transected patellar tendon.
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