Development of Tissue Engineering for Vascularization based on regulation of interstitial flow
| Project/Area Number |
25282135
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Keio University |
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Principal Investigator |
SUDO RYO 慶應義塾大学, 理工学部, 准教授 (20407141)
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| Co-Investigator(Kenkyū-buntansha) |
TANISHITA KAZUO 早稲田大学, ナノ・ライフ創新研究機構, 上級研究員(研究院教授) (10101776)
MITAKA TOSHIHIRO 札幌医科大学, 医学部, 教授 (50231618)
USHIYAMA AKIRA 国立保健医療科学院, 生活環境研究部, 上席主任研究官 (60291118)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | マイクロ流体デバイス / 肝臓 / 血管 / 組織工学 / 三次元培養 / 血管化 / 生体工学 |
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| Outline of Final Research Achievements |
It is necessary to reconstruct three-dimensional (3D) complex organs in current tissue engineering. In particular, construction 3D complex tissues including microvascular networks is a big challenge. In this study, we investigated a technology to vascularize 3D hepatocyte tissues. Specifically, we could construct 3D hepatocyte tissues with microvessels by controlling the timing of vascular formation and hepatocyte tissue formation in 3-channel microfluidic devices. Furthermore, we demonstrated hepatocyte-conditioned medium and collagen gel microspheres could promote vascularization of hepatocyte tissues.
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Report
(4 results)
Research Products
(87 results)
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[Journal Article] Tacrolimus inhibits the revascularization of isolated pancreatic islets2013
Author(s)
Ryuichi Nishimura, Sho Nishioka, Ikuma Fujisawa, Hitoshi Shiku, Miki Shimada, Satoshi Sekiguchi, Keisei Fujimori, Akira Ushiyama, Tomokazu Matsue, Noriaki Ohuchi, Susumu Satomi, Masafumi Goto
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Peer Reviewed
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[Presentation] Tacrolimus inhibits the revascularization of isolated pancreatic islets2013
Author(s)
Ryuichi Nishimura, Satoshi Sekiguchi, Noriaki Ohuchi, Susumu Satomi, Masafumi Goto, Sho Nishioka, Ikuma Fujisawa, Hitoshi Shiku, Miki Shimada, Akira Ushiyama, Tomokazu Matsue
Organizer
14th World Congress of the International Pancreas and Islet Transplant Association (IPITA 2013)
Place of Presentation
Monterey, CA, USA
Related Report
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