| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Outline of Final Research Achievements |
It is necessary to reconstruct three-dimensional (3D) complex organs in current tissue engineering. In particular, construction 3D complex tissues including microvascular networks is a big challenge. In this study, we investigated a technology to vascularize 3D hepatocyte tissues. Specifically, we could construct 3D hepatocyte tissues with microvessels by controlling the timing of vascular formation and hepatocyte tissue formation in 3-channel microfluidic devices. Furthermore, we demonstrated hepatocyte-conditioned medium and collagen gel microspheres could promote vascularization of hepatocyte tissues.
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