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Development of titanium with ex vivo antibacterial activity and in vivo osteoconductivity

Research Project

Project/Area Number 25282139
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionTohoku University

Principal Investigator

Kawashita Masakazu  東北大学, 医工学研究科, 准教授 (70314234)

Co-Investigator(Kenkyū-buntansha) KANETAKA Hiroyasu  東北大学, 大学院歯学研究科, 准教授 (50292222)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2015: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2014: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Keywordsチタン / 窒素 / 可視光応答光触媒 / 抗菌性 / 生体活性 / 窒素ドープ / 可視光応答型光触媒 / 可視光応答型光触媒活性 / 光触媒特性 / 可視光応答
Outline of Final Research Achievements

Ti treated with NaOH, hot water, and heated in an ammmonia gas atmosphere for 1 or 3 h showed in vitro apatite formation within 7 days when soaked in simulated body fluid (SBF). The treated Ti decomposed methylene blue and showed excellent bactericidal activity against Escherichia coli under visible light irradiation. A fine network of N-doped anatase-type titania (TiO2-xNx) formed on the Ti surface due to the surface treatment and was responsible for both the apatite formation in SBF and the visible-light induced antibacterial activity. These preliminary results suggest a simple method for producing novel bioactive Ti with visible light-induced antibacterial activity, which can be applied in orthopaedic and dental implants without the risk of infection.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (22 results)

All 2015 2014 2013 Other

All Journal Article (4 results) (of which Acknowledgement Compliant: 1 results,  Peer Reviewed: 3 results) Presentation (14 results) (of which Int'l Joint Research: 2 results,  Invited: 6 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] 可視光に応答して抗菌性を示す生体活性チタン2015

    • Author(s)
      川下将一
    • Journal Title

      チタン

      Volume: 63 Pages: 22-28

    • NAID

      40020542713

    • Related Report
      2015 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] In vitro apatite formation and visible-light photocatalytic activity of Ti metal subjected to chemical and thermal treatments2014

    • Author(s)
      M. Kawashita, Y. Yokohama, X. Y. Cui, T. Miyazaki and H. Kanetaka.
    • Journal Title

      Ceram. Int

      Volume: (印刷中) Issue: 8 Pages: 12629-12636

    • DOI

      10.1016/j.ceramint.2014.04.109

    • NAID

      120005890538

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of ammonia or nitric acid treatment on surface structure, in vitro apatite formation, and visible-light photocatalytic activity of bioactive titanium metal2013

    • Author(s)
      M. Kawashita, N. Matsui, T. Miyazaki and H. Kanetaka.
    • Journal Title

      Colloids Surf. B

      Volume: Vol. 111 Pages: 503-508

    • DOI

      10.1016/j.colsurfb.2013.06.049

    • NAID

      120005890545

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design of Biomedical Materials for Treatment of Cancer and Bone Diseases2013

    • Author(s)
      川下将一
    • Journal Title

      Journal of the Japan Society of Powder and Powder Metallurgy

      Volume: 60 Issue: 12 Pages: 503-509

    • DOI

      10.2497/jjspm.60.503

    • NAID

      130003393298

    • ISSN
      0532-8799, 1880-9014
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Bioactive Titanium with Visible-light Induced Antibacterial Activity2015

    • Author(s)
      M. Kawashita, N. Endo, T. Watanabe, T. Miyazaki, M. Furuya, K. Yokota, Y. Abiko, H. Kanetaka, N. Takahashi
    • Organizer
      15th Asian BioCeramics symposium
    • Place of Presentation
      Tokyo Medical and Dental University, Tokyo
    • Year and Date
      2015-12-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 表面化学処理および加熱処理によるチタンへのアパタイト形成能と可視光応答型抗菌性の付与2015

    • Author(s)
      川下将一
    • Organizer
      粉体粉末冶金協会平成27年度秋季大会
    • Place of Presentation
      京都大学百周年時計台記念館、京都
    • Year and Date
      2015-11-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 窒素ドープ酸化チタンを形成させたチタンのアパタイト形成能と可視光下での抗菌性2015

    • Author(s)
      川下将一、遠藤真子、渡邉友亮、宮崎敏樹、古谷真衣子、横田琴音、安彦友希、金高弘恭、高橋信博
    • Organizer
      第37回日本バイオマテリアル学会大会
    • Place of Presentation
      京都テルサ、京都
    • Year and Date
      2015-11-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] Development of biomedical materials for cancer treatment and bone-repairing2015

    • Author(s)
      M. Kawashita
    • Organizer
      Seminar in Institute of Metal Research
    • Place of Presentation
      Institute of Metal Research, Chinese Academy of Sciences, Shenyang, China
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Bioactive titanium with visible-light induced photocatalytic activity2015

    • Author(s)
      M. Kawashita
    • Organizer
      5th International Conference on Recent Advances in Materials, Minerals & Environment (RAMM) & 2nd International Postgraduate Conference on Materials, Mineral and Polymer (MAMIP)
    • Place of Presentation
      Penang, Malaysia
    • Year and Date
      2015-08-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] チオ尿素水溶液中での水熱処理がNaOH処理チタンの表面構造と特性に及ぼす影響2015

    • Author(s)
      川下将一、古川崇、宮崎敏樹、目代貴之、庭野吉己、金高弘恭
    • Organizer
      日本セラミックス協会2014年年会
    • Place of Presentation
      岡山大学、岡山市
    • Year and Date
      2015-03-18 – 2015-03-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] チオ尿素を利用した水熱処理がチタンのアパタイト形成に与える影響2014

    • Author(s)
      古川崇、川下将一、崔新宇、宮崎敏樹、金高弘恭
    • Organizer
      第23回アパタイト研究会
    • Place of Presentation
      富山県民共生センター、富山市
    • Year and Date
      2014-12-11 – 2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Formation of bioactive sulfur-doped titanium dioxide with visible-light photocatalytic activity on titanium by hydrothermal treatment2014

    • Author(s)
      S. Furukawa, M. Kawashita, X. Cui, T. Miyazaki and H. Kanetaka
    • Organizer
      14th Asian BioCeramics Symposium (ABC2014)
    • Place of Presentation
      Rainbow Hotel, Shanghai, China
    • Year and Date
      2014-10-28 – 2014-10-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 可視光応答型光触媒活性を示すバイオアクティブチタンの開発2014

    • Author(s)
      川下将一
    • Organizer
      東北大学金属材料研究所ワークショップおよび日本バイオマテリアル学会東北ブロック講演会
    • Place of Presentation
      東北大学金属材料研究所、仙台市
    • Year and Date
      2014-10-06 – 2014-10-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] アンモニア雰囲気中で加熱処理した生体活性チタンのアパタイト形成能および可視光誘起光触媒特性2014

    • Author(s)
      川下将一、遠藤真子、渡辺友亮、宮崎敏樹、金高弘恭
    • Organizer
      日本セラミックス協会2014年年会
    • Place of Presentation
      慶応大学日吉キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] がんや骨疾患の治療に貢献する医用材料の設計2013

    • Author(s)
      川下将一
    • Organizer
      粉体粉末冶金協会平成25年度春季大会
    • Place of Presentation
      早稲田大学国際会議場
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 可視光応答型抗菌性窒素ドープチタン金属の作製とそのアパタイト形成能評価2013

    • Author(s)
      横浜優人、川下将一、崔新宇、宮崎敏樹、金高弘恭
    • Organizer
      第35回日本バイオマテリアル学会大会
    • Place of Presentation
      タワーホール船堀
    • Related Report
      2013 Annual Research Report
  • [Presentation] Preparation of bioactive titanium metals with photocatalytic activity via anodic oxidation2013

    • Author(s)
      X. Cui, M. Kawashita, T. Xiong, Y. Yokohama, S. Furukawa and H. Kanetaka
    • Organizer
      13th Asian BioCeramics Symposium (ABC2013)
    • Place of Presentation
      京都大学吉田キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] Development of bioactive titanium metal with visible-light photocatalytic activity2013

    • Author(s)
      M. Kawashita, N. Matsui, T. Miyazaki, T. Watanabe, X.-Y. Cui and H. Kanetaka
    • Organizer
      23rd Annual Meeting of MRS-J
    • Place of Presentation
      横浜情報文化センター
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Remarks] 生体活性骨修復用材料に関する研究

    • URL

      http://www.ecei.tohoku.ac.jp/kawashita/research.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 川下研究室>研究内容

    • URL

      http://www.ecei.tohoku.ac.jp/kawashita/research.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 川下研究室>研究内容

    • URL

      http://www.ecei.tohoku.ac.jp/kawashita/research.html

    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] チタン金属又はチタン合金からなる基体を有する生体インプラ ントおよびその製造方法2015

    • Inventor(s)
      川下将一
    • Industrial Property Rights Holder
      川下将一
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-073673
    • Filing Date
      2015-03-31
    • Related Report
      2014 Annual Research Report

URL: 

Published: 2013-05-21   Modified: 2019-07-29  

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