Development of titanium with ex vivo antibacterial activity and in vivo osteoconductivity
| Project/Area Number |
25282139
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KANETAKA Hiroyasu 東北大学, 大学院歯学研究科, 准教授 (50292222)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2015: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2014: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
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| Keywords | チタン / 窒素 / 可視光応答光触媒 / 抗菌性 / 生体活性 / 窒素ドープ / 可視光応答型光触媒 / 可視光応答型光触媒活性 / 光触媒特性 / 可視光応答 |
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| Outline of Final Research Achievements |
Ti treated with NaOH, hot water, and heated in an ammmonia gas atmosphere for 1 or 3 h showed in vitro apatite formation within 7 days when soaked in simulated body fluid (SBF). The treated Ti decomposed methylene blue and showed excellent bactericidal activity against Escherichia coli under visible light irradiation. A fine network of N-doped anatase-type titania (TiO2-xNx) formed on the Ti surface due to the surface treatment and was responsible for both the apatite formation in SBF and the visible-light induced antibacterial activity. These preliminary results suggest a simple method for producing novel bioactive Ti with visible light-induced antibacterial activity, which can be applied in orthopaedic and dental implants without the risk of infection.
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Report
(4 results)
Research Products
(22 results)
