stent optimization for endothelialization with flow condition

• Project/Area Number: 25282140
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Tohoku University
• Principal Investigator: OHTA MAKOTO 東北大学, 流体科学研究所, 准教授 (20400418)
• Co-Investigator(Kenkyū-buntansha): Iwata Hiroo 京都大学, 再生医科学研究所, 教授 (30160120) ; Kobayashi Hisatoshi 国立研究開発法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, グーループリーダ (90354266)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000); Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
• Keywords: ステント / 脳動脈瘤 / 内皮細胞 / 最適化 / 血栓 / 表面処理 / PIV

Outline of Final Research Achievements

The most effective results in this project is development of program for optimization of stent design and the success of endothelialization using improvement of surface of stent. Next generation of stent is necessary for avoiding restenosis and recanalization. To solve these problems, this project was performed for optimization of stent designs and surface treatment. The results show that the development of program leads the optimization of stent for thrombosis.

Research Products

• [Int'l Joint Research] ジュネーブ大学(スイス)
• [Int'l Joint Research] ECL(フランス)
• [Int'l Joint Research] マッコーリ大学(オーストラリア)
• [Int'l Joint Research] ジュネーブ大学(スイス)
• [Int'l Joint Research] INSA-Lyon(フランス)
• [Int'l Joint Research] マッコーリ大学(オーストラリア)
• [Journal Article] Porosity Dependency of an Optimized Stent Design for Intracranial Aneurysm (2015)
  • Author(s): H. Anzai, Y. Yoshida, S. Sugiyama, H. Endo, Y. Matsumoto, M. Ohta
  • Journal Title: Technology and Health Care Volume: 23 Issue: 1 Pages: 547-556
  • DOI: 10.3233/thc-140870
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Influence of plaque stiffness on deformation and blood flow patterns in models of stenosis (2015)
  • Author(s): Yasutomo Shimizu, Makoto Ohta
  • Journal Title: Biorheology Volume: 52 Issue: 3 Pages: 171-182
  • DOI: 10.3233/bir-14016
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Manufacture-Oriented Design Optimization for a Flow Diverter Stent Using Lattice Boltzmann Method and Simulated Annealing (2015)
  • Author(s): Mingzi Zhang, Hitomi Anzai, Bastien Chopard, Makoto Ohta
  • Journal Title: Advances in Structural and Multidisciplinary Optimization - Proceedings of the 11th World Congress of Structural and Multidisciplinary Optimization (WCSMO-11) Volume: 1 Pages: 310-315
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Parametric study of porous media as substitutes for flow-diverter stent (2015)
  • Author(s): Makoto Ohta, Hitomi Anzai, Yukihisa Miura and Toshio Nakayama
  • Journal Title: Biomaterials and Biomedical Engineering Volume: 2 Pages: 111-125
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Optimization of Strut Placement in Flow Diverter Stents for Four Different Aneurysm Configurations (2014)
  • Author(s): Hitomi Anzai, Jean-Luc Falcone, Bastien Chopard, Toshiyuki Hayase, Makoto Ohta
  • Journal Title: Journal of Biomechanical Engineering Volume: 136 Issue: 5 Pages: 061006-061006
  • DOI: 10.3233/thc-151007
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Combinational optimization of strut placement for intracranial stent using a realistic aneurysm (2014)
  • Author(s): Hitomi Anzai, Bastien Chopard, Makoto Ohta
  • Journal Title: Journal of Flow Control, Measurement & Visualization Volume: 2 Pages: 66-76
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Simulation of hemodynamics in artery with aneurysm and stenosis with different geometric configuration (2014)
  • Author(s): Yujie Li, Hitomi Anzai, Toshio Nakayama, Yasumoto Shimizu, Yukihisa Miura, Aike Qiao, Makoto Ohta
  • Journal Title: Journal of Biomechanical Science and Engineering Volume: 9 Issue: 1 Pages: JBSE0003-JBSE0003
  • DOI: 10.1299/jbse.2014jbse0003
  • NAID: 130003393144
  • ISSN: 1880-9863
  • Peer Reviewed / Open Access
• [Journal Article] Study of Parameters for Evaluating the Pushability of Interventional Devices Using Box-shaped Blood Vessel Biomodels Made of PVA-H or Silicone (2014)
  • Author(s): Yu Chang Ho, Makoto Ohta, Kwon Tae Kyu
  • Journal Title: BIO-MEDICAL MATERIALS AND ENGINEERING Volume: 24 Pages: 961-968
  • Peer Reviewed
• [Journal Article] High Fidelity Virtual Stenting (HiFiVS) for Intracranial Aneurysm Flow Diversion: In Vitro and In Silico (2013)
  • Author(s): Ding Ma, Travis M.Dumont, Hiroyuki Kosukegawa, Makoto Ohta, Xinjian Yang, Adnan H.Siddiqui, Hui Meng
  • Journal Title: Annals of Biomedical Engineering Volume: 41(10) Issue: 10 Pages: 2143-2156
  • DOI: 10.1007/s10439-013-0808-4
  • Peer Reviewed
• [Journal Article] Flow observations in elastic stenosis biomodel with comparison to rigid-like model (2013)
  • Author(s): Yasutomo Shimizu, Ashkan Javadzadegan, Toshiyuki Hayase, Makoto Ohta
  • Journal Title: Technology and Health care Volume: 21 Issue: 4 Pages: 140-152
  • DOI: 10.3233/thc-130725
  • Peer Reviewed
• [Journal Article] Correlation between Reynolds number and eccentricity effect in stenosed artery models (2013)
  • Author(s): Ashkan Javadzadegan, Yasutomo Shimizu, Masud Behnia, Makoto Ohta
  • Journal Title: Technology and Health Care Volume: 21 Issue: 4 Pages: 357-367
  • DOI: 10.3233/thc-130736
  • Peer Reviewed
• [Presentation] 動脈瘤ネックの流入領域に対するストラットの相対位置が瘤内流れに与える影響 (2016)
  • Author(s): 渡邉 和浩，安西 眸，太田 信
  • Organizer: 第28回バイオエンジニアリング講演会
  • Place of Presentation: 東京 大岡山
  • Year and Date: 2016-01-09
• [Presentation] Development of a Program for Blood flow and Cell Behaviors Based on LBM Method (third report) (2015)
  • Author(s): Makoto Ohta, Mingzi, Zhang, Bastien Chopard, Xiaobo Han, Yujie Li, Hitomi Anzai
  • Organizer: AFI-TFI
  • Place of Presentation: 宮城 仙台
  • Year and Date: 2015-11-13
  • Int'l Joint Research
• [Presentation] Visualization of Flow Patterns through the Aneurysmal Orifice after Flow Diverter Optimizations with Different Objective Functions (2015)
  • Author(s): Zhang M, Anzai H, Ohta M
  • Organizer: Interdisciplinary Cerebrovascular Symposium (Intracranial Stent Meeting 2015)
  • Place of Presentation: オーストラリア シドニー
  • Year and Date: 2015-11-13
  • Int'l Joint Research
• [Presentation] Analysis of Relationship Between Stent Structure and Flow Stagnation Using Self-Organizing Maps for Realistic Aneurysm (2015)
  • Author(s): Anzai H, Yoshida Y, Shimoyama K, Obayashi S, Ohta M
  • Organizer: Interdisciplinary Cerebrovascular Symposium (Intracranial Stent Meeting 2015)
  • Place of Presentation: オーストラリア シドニー
  • Year and Date: 2015-11-13
  • Int'l Joint Research / Invited
• [Presentation] In-Vitro Model with Flow for Surface Treatment for Endothelialization (2015)
  • Author(s): Ohta M, Matsumoto S, Watanabe T, Han XB, Kobayashi H
  • Organizer: Interdisciplinary Cerebrovascular Symposium (Intracranial Stent Meeting 2015)
  • Place of Presentation: オーストラリア シドニー
  • Year and Date: 2015-11-13
  • Int'l Joint Research / Invited
• [Presentation] 平均および最大流速の最適脳動脈瘤用ステントデザイン (2015)
  • Author(s): 張明子，安西眸，太田信
  • Organizer: 流体力学会年会2015
  • Place of Presentation: 東京 大岡山
  • Year and Date: 2015-09-25
• [Presentation] 脳動脈瘤治療用ステントにおける自己組織化マップを用いた最適形状解析 (2015)
  • Author(s): 安西眸，吉田裕貴，下山幸治，大林茂，太田信
  • Organizer: 日本機械学会2015年度年次大会
  • Place of Presentation: 北海道 札幌
  • Year and Date: 2015-09-13
• [Presentation] Surface treatment on wire for increasing endothelialization (2015)
  • Author(s): Makoto Ohta, Sho Matsumoto, Xiaobo Han, Hisatoshi Kobayashi
  • Organizer: 9th European Solid Mechanics Conference
  • Place of Presentation: スペイン マドリード
  • Year and Date: 2015-07-06
  • Int'l Joint Research / Invited
• [Presentation] Searching for valuable hemodynamic parameters for applying to optimization study (2015)
  • Author(s): Hitomi Anzai, Yuuki Yoshida, Mingzi Zhang, Makoto Ohta
  • Organizer: 9th European Solid Mechanics Conference
  • Place of Presentation: スペイン マドリード
  • Year and Date: 2015-07-06
  • Int'l Joint Research / Invited
• [Presentation] Design analysis using optimization (2015)
  • Author(s): Makoto Ohta
  • Organizer: Special lecture in BJUT
  • Place of Presentation: 中国 北京
  • Year and Date: 2015-06-23
  • Int'l Joint Research / Invited
• [Presentation] Introduction of Optimization of Design using Combination of Lattice Boltzmann Method as CFD and Simulated Annealing for Reduction of Flow Speed (2015)
  • Author(s): Mingzi Zhang, Hitomi Anzai, Makoto Ohta
  • Organizer: 1st NUAA-Tohoku University Joint Symposium on Fluid Science, Aerospace Engineering and Smart Structure Technology
  • Place of Presentation: 中国 南京
  • Year and Date: 2015-06-21
  • Int'l Joint Research
• [Presentation] Manufacture-Oriented Design Optimization for a Flow Diverter Stent Using Lattice Boltzmann Method and Simulated Annealing (2015)
  • Author(s): Mingzi Zhang, Hitomi Anzai, Bastien Chopard, Makoto Ohta
  • Organizer: 11th World Congress of Structural and Multidisciplinary Optimization (WCSMO-11)
  • Place of Presentation: オーストラリア シドニー
  • Year and Date: 2015-06-07
  • Int'l Joint Research
• [Presentation] Optimization of endovascular prosthesis for the treatment ofcerebral aneurysms (2015)
  • Author(s): Makoto Ohta, Guy courbebaisse, Hitomi Anzai, Mingzi Zhang, Bastien Chopard, Yue zhang
  • Organizer: 2015 ELyT lab Workshop
  • Place of Presentation: 宮城 松島
  • Year and Date: 2015-02-18
  • Int'l Joint Research
• [Presentation] Introduction of Three Strut Optimization Strategies towards the Design of Efficient Flow-Diverter Stents (2015)
  • Author(s): Mingzi Zhang, Makoto Ohta
  • Organizer: 2015 ELyT lab Workshop
  • Place of Presentation: 宮城 松島
  • Year and Date: 2015-02-18
  • Int'l Joint Research
• [Presentation] Automation of design optimization for intracranial stent (2014)
  • Author(s): Hitomi Anzai, Yuuki Yoshida, Mingzi Zhang, Makoto Ohta
  • Organizer: 1st International symposium for collaborative research between Tohoku University and Technische Universitt Braunschweig
  • Place of Presentation: ドイツ ブラウンシュバイグ
  • Year and Date: 2014-11-11
  • Int'l Joint Research / Invited
• [Presentation] A Development of Manufactureoriented Optimization Strategy for Flow Diverter Stent based on Cylindrical Spirals (2014)
  • Author(s): Mingzi Zhang, Hitomi Anzai, Bastien Chopard, Makoto Ohta
  • Organizer: 11th International Conference on Flow Dynamics (ICFD2014)
  • Place of Presentation: 宮城 仙台
  • Year and Date: 2014-10-08
  • Int'l Joint Research
• [Presentation] Development of a Program for Blood flow and Cell Behaviors Based on LBM Method (Second report) (2014)
  • Author(s): Makoto Ohta, Sho Matsumoto, Xiabo Han, Batien Chopard, Mingzi Zhang, Yujie Li, Yuuki Yoshida, Hitomi Anzai
  • Organizer: The Fourteenth International Symposium on. Advanced Fluid Information
  • Place of Presentation: 宮城 仙台
  • Year and Date: 2014-10-08
  • Int'l Joint Research
• [Presentation] 数値流体力学に基づくステントストラット配置最適化 (2014)
  • Author(s): 安西 眸，太田 信
  • Organizer: 日本流体力学会年会2014
  • Place of Presentation: 宮城 仙台
  • Year and Date: 2014-09-15
• [Presentation] せん断応力環境下においてNiTiワイヤの表面加工が内皮化に与える影響 (2014)
  • Author(s): 松本 翔，韓 笑波，小林 尚俊， 太田 信
  • Organizer: 日本機械学会2014年度年次大会
  • Place of Presentation: 東京 大岡山
  • Year and Date: 2014-09-07
• [Presentation] Optimization of stent design for intracranial aneurysm (2014)
  • Author(s): Hitomi Anzai, Yuuki Yoshida, Makoto Ohta
  • Organizer: The Fourth Japan-Switzerland Workshop on Biomechamics (JSB2014)
  • Place of Presentation: 三重 志摩
  • Year and Date: 2014-09-01
  • Int'l Joint Research
• [Presentation] An Optimization Method of FD Stent for Cerebral Aneurysm facing tne Stent Design and Manufacturing Needs (2014)
  • Author(s): Mingzi Zhang, Hitomi Anzai, Bastien Chopard, Makoto Ohta
  • Organizer: The Fourth Japan-Switzerland Workshop on Biomechamics (JSB2014)
  • Place of Presentation: 三重 志摩
  • Year and Date: 2014-09-01
  • Int'l Joint Research
• [Presentation] Development of Image Guided Minimal Invasive Treatments (2014)
  • Author(s): Makoto Ohta, Sho Matsumoto, Xiaobo Han, Mingzi Zhang, Yujie Li, Kaihong Yu, Hitomi Anzai
  • Organizer: The Fourth Japan-Switzerland Workshop on Biomechamics (JSB2014)
  • Place of Presentation: 三重 志摩
  • Year and Date: 2014-09-01
  • Int'l Joint Research
• [Presentation] Manufacture-oriented Struts Structure Optimization of Flow Diverter for Intracranial Aneurysm (2014)
  • Author(s): Mingzi Zhang, Hitomi Anzai, Makoto Ohta
  • Organizer: 7th World Congress of Biomechanics (WCB2014)
  • Place of Presentation: アメリカ ボストン
  • Year and Date: 2014-07-06
  • Int'l Joint Research
• [Presentation] The concept of Bundle of Inflow (BOI) for reducing flow in aneurysm (2014)
  • Author(s): Makoto Ohta, Hitomi Anzai, Mingzi Zhang, Yujie Li, Xiaobo Han, Kaihong Yu, Toshio Nakayama
  • Organizer: 7th World Congress of Biomechanics (WCB2014)
  • Place of Presentation: アメリカ ボストン
  • Year and Date: 2014-07-06
  • Int'l Joint Research / Invited
• [Presentation] 脳動脈瘤治療用ステントにおける数値解析を用いた最適設計 (2014)
  • Author(s): 安西眸，Bastien Chopard，中山敏男，張明子，吉田裕貴，太田信
  • Organizer: 第19回計算工学講演会
  • Place of Presentation: 広島 広島
  • Year and Date: 2014-06-11
• [Presentation] Application of optimization for design of intracranial stent with blood flow reduction as objective function
  • Author(s): Hitomi Anzai, Jean-Luc Falcone, Bastien Chopard, Makoto Ohta
  • Organizer: World Congress on Structural and Multidisciplinary Optimization
  • Place of Presentation: フロリダ，アメリカ
• [Presentation] Correlation between Reynolds number and stenosis morphology in eccentric and concentric artery models
  • Author(s): Ashkan Javadzadegan, Yasutomo Shimizu, Masud Behnia, Makoto Ohta
  • Organizer: PIV 2013
  • Place of Presentation: ダルフト，オランダ
• [Presentation] Classification of flow pattern in neck based considering the parent artery curves and stent implantation
  • Author(s): Toshio Nakayama, Makoto Ohta
  • Organizer: ICS2013
  • Place of Presentation: ブエノスアイレス，アルゼンチン
• [Presentation] Classification of blood flow in cerebral aneurysm considering the parent artery curves
  • Author(s): Toshio Nakayama, Shin-ichiro Sugiyama, Makoto Ohta
  • Organizer: ASME 2013 International Mechanical Engineering Congress & Exposition
  • Place of Presentation: サンディエゴ，アメリカ
• [Presentation] Influence of Ni-Ti Wire under the Shear Stress Environment on Endothelialization
  • Author(s): Sho Matsumoto, Han Xiaobo, Hisatoshi Kobayashi, Noriko Tomita, Makoto Ohta
  • Organizer: The 10th ICFD
  • Place of Presentation: 仙台，日本
• [Presentation] Optimized Stent
  • Author(s): Makoto Ohta. Hitomi Anzai, Toshio Nakayama, Xiaobo Han, Noriko Tomita
  • Organizer: The 10th ICFD
  • Place of Presentation: 仙台，日本
  • Invited
• [Presentation] Hemodynamic Numerical Simulation in Artery Complicated with both Stenosis and Aneurysm in Different Shape and Position
  • Author(s): Y.J.Li, H.Anzai, T.Nakayama, Y.Shimizu, Y.Miura, A.K.Qiao M.Ohta
  • Organizer: The 5th Asia Pacific Congress on Computational Mechanics
  • Place of Presentation: シンガポール，シンガポール
• [Presentation] A Study on Multiscale Model in the presence of Systemic-to-Pulmonary Shunt utilizing LBM-LPM
  • Author(s): M.Z.Zhang, H.Anzai, Y.J.Liu, M.Ohta
  • Organizer: The 5th Asia Pacific Congress on Computational Mechanics
  • Place of Presentation: シンガポール，シンガポール
• [Presentation] Comparison of flow patterns around stenotic area in elastic PVA-H model and in rigid-like silicone model
  • Author(s): Yasutomo Shimizu, Masanori Kuze, Ashkan Javadzadegan, Masud Behnia, Makoto Ohta
  • Organizer: PIV 2013
  • Place of Presentation: ダルフト，オランダ
• [Presentation] Optimization of stent design to increase the porosity
  • Author(s): Yuuki Yoshida, Hitomi Anzai, Makoto Ohta
  • Organizer: ICS2013
  • Place of Presentation: サンディエゴ，アメリカ
• [Presentation] Development of a Program for Blood flow and Cell Behaviors Based on LBM Method
  • Author(s): Makoto Ohta, Bastien Chopard, Hitomi Anzai
  • Organizer: the 13th International Symposium on Advanced Fluid Information(AFI-2013)
  • Place of Presentation: 仙台，日本
• [Presentation] Optimization of blood flow for intracranial stent
  • Author(s): Makoto Ohta, Hitomi Anzai, Han Xiaobo
  • Organizer: International Workshop on Flow Dynamics related to Energy, Aerospace and Material
  • Place of Presentation: ストックホルム，スエーデン
  • Invited
• [Remarks] 太田研HPP
  • URL: http://www.ifs.tohoku.ac.jp/bfc/html/ohta_member.html
• [Remarks] 太田研HP
  • URL: http://www.ifs.tohoku.ac.jp/bfc/html/index_ohta_j.html
• [Remarks] 発表論文
  • URL: http://www.ifs.tohoku.ac.jp/bfc/html/ohta_article_13.html