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Precise construction of single siRNA-loaded self-assemblies for siRNA delivery

Research Project

Project/Area Number 25282141
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionThe University of Tokyo

Principal Investigator

Miyata Kanjiro  東京大学, 工学(系)研究科(研究院), 准教授 (50436523)

Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2016: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywords核酸医薬デリバリー / siRNA / ブロック共重合体 / ポリイオンコンプレックス / 薬物送達システム / 核酸医薬 / 核酸医薬送達
Outline of Final Research Achievements

This study aimed to develop an "siRNA carrier" that allows for safe and efficient siRNA delivery to solid tumors. Particularly, a single siRNA-loaded polyion complex, termed unit PIC, was constructed as a smallest delivery formulation featuring high tissue permeability. The obtained results demonstrated that 1) fine-tuning of the chemical structure and chain length of block catiomers enabled the selective formation of unit PICs, and 2) the optimized unit PIC exerted the excellent blood circulation property and tumor accumulation profile, leading to the enhanced antitumor activity.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (66 results)

All 2017 2016 2015 2014 2013 Other

All Journal Article (19 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 13 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (35 results) (of which Int'l Joint Research: 7 results,  Invited: 26 results) Book (6 results) Remarks (6 results)

  • [Journal Article] Multilayered polyion complexes with dissolvable silica layer covered by controlling densities of cRGD-conjugated PEG chains for cancer-targeted siRNA delivery.2017

    • Author(s)
      M. Naito, R. Azuma, H. Takemoto, M. Hori, N. Yoshinaga, S. Osawa, R. Kamegawa, H. -J. Kim, T. Ishii, N. Nishiyama, K. Miyata, K. Kataoka
    • Journal Title

      J. Biomater. Sci. Polym.

      Volume: 28 Issue: 10-12 Pages: 1109-1123

    • DOI

      10.1080/09205063.2017.1301775

    • Description
      【掲載確定】 in press
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Targeting the Notch-regulated non-coding RNA TUG1 for glioma treatment.2016

    • Author(s)
      Katsushima K, Natsume A, Ohka F, Shinjo K, Hatanaka A, Ichimura N, Sato S, Takahashi S, Kimura H, Totoki Y, Shibata T, Naito M, Kim HJ, Miyata K, Kataoka K, Kondo Y.
    • Journal Title

      Nat Commun.

      Volume: 7 Issue: 1 Pages: 13616-13616

    • DOI

      10.1038/ncomms13616

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Targeted systemic delivery of siRNA to cervical cancer model using cyclic RGD-installed unimer polyion complex-assembled gold nanoparticles2016

    • Author(s)
      Yi, Y., Kim, H. J., Mi, P., Zheng, M., Takemoto, H., Toh, K., Kim, B. S., Hayashi, K., Naito, M., Matsumoto, Y., Miyata, K., Kataoka, K.
    • Journal Title

      J Control Release

      Volume: 244 Pages: 247-256

    • DOI

      10.1016/j.jconrel.2016.08.041

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Systemic delivery of siRNA by actively targeted polyion complex micelles for silencing the E6 and E7 human papillomavirus oncogenes2016

    • Author(s)
      Nishida H, Matsumoto Y, Kawana K, Christie RJ, Naito M, Kim BS, Toh K, Min HS, Yi Y, Matsumoto Y, Kim HJ, Miyata K, Taguchi A, Tomio K, Yamashita A, Inoue T, Nakamura H, Fujimoto A, Sato M, Yoshida M, Adachi K, Arimoto T, Wada-Hiraike O, Oda K, Nagamatsu T, Nishiyama N, Kataoka K, Osuga Y, Fujii T
    • Journal Title

      J Control Release

      Volume: 231 Pages: 29

    • DOI

      10.1016/j.jconrel.2016.03.016

    • URL

      https://pure.teikyo.jp/en/publications/1246fd42-3a7f-4b6e-b89e-7b96f138ec83

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Hydroxychloroquine-conjugated gold nanoparticles for improved siRNA activity2016

    • Author(s)
      Federico Perche, Yu Yi, Louise Hespel, Peng Mi, Anjaneyulu Dirisala, Horacio Cabral, Kanjiro Miyata, Kazunori Kataoka
    • Journal Title

      Biomaterials

      Volume: 90 Pages: 62-71

    • DOI

      10.1016/j.biomaterials.2016.02.027

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Influence of RNA strand rigidity on polyion complex formation with block catiomers.2016

    • Author(s)
      K. Hayashi, H. Chaya, S. Fukushima, S. Watanabe, H. Takemoto, K. Osada, N. Nishiyama, K. Miyata, K. Kataoka
    • Journal Title

      Macromol. Rapid Commun.

      Volume: 37 Issue: 6 Pages: 486-493

    • DOI

      10.1002/marc.201500661

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] siRNA-loaded polyion complex micelle decorated with charge-conversional polymer tuned to undergo stepwise response to intra-tumoral and intra-endosomal pHs for exerting enhanced RNAi efficacy.2016

    • Author(s)
      M. Tangsangasaksri, H. Takemoto, M. Naito, Y. Maeda, D. Sueyoshi, H. -J. Kim, Y. Miura, J. -Y. Ahn, R. Azuma, N. Nishiyama, K. Miyata, K. Kataoka
    • Journal Title

      Biomacromolecules

      Volume: 17 Issue: 1 Pages: 246-255

    • DOI

      10.1021/acs.biomac.5b01334

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] リガンド搭載高分子ミセルを用いた組織特異的核酸デリバリー2016

    • Author(s)
      内藤瑞樹、宮田完二郎
    • Journal Title

      日本認知症学会誌 Dementia Japan

      Volume: 30 Pages: 2-8

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 高分子ナノテクノロジーが切り拓く核酸医薬デリバリー2016

    • Author(s)
      宮田完二郎、他
    • Journal Title

      Drug Delivery System

      Volume: 31 Pages: 44-53

    • NAID

      130005147215

    • Related Report
      2015 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] Development of Nucleic Acid Delivery System Based on Polymeric Materials2015

    • Author(s)
      宮田完二郎
    • Journal Title

      Drug Delivery System

      Volume: 30 Issue: 4 Pages: 363-370

    • DOI

      10.2745/dds.30.363

    • NAID

      130005116538

    • ISSN
      0913-5006, 1881-2732
    • Related Report
      2015 Annual Research Report
    • Open Access
  • [Journal Article] Precise engineering of siRNA delivery vehicles to tumors using polyion complexes and gold nanoparticles2014

    • Author(s)
      H. -J. Kim, H. Takemoto, Y. Yi, M. Zheng, Y. Maeda, H. Chaya, K. Hayashi, P. Mi, F. Pittella, R. J. Christie, K. Toh, Y. Matsumoto, N. Nishiyama, K. Miyata, K. Kataoka
    • Journal Title

      ACS Nano

      Volume: 8 Issue: 9 Pages: 8979-8991

    • DOI

      10.1021/nn502125h

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Actively-targeted polyion complex micelles stabilized by cholesterol and disulfide cross-linking for systemic delivery of siRNA to solid tumors2014

    • Author(s)
      Y. Oe, R. J. Christie, M. Naito, S. A. Low, S. Fukushima, K. Toh, Y. Miura, Y. Matsumoto, N. Nishiyama, K. Miyata, K. Kataoka
    • Journal Title

      Biomaterials

      Volume: 35 Issue: 27 Pages: 7887-7895

    • DOI

      10.1016/j.biomaterials.2014.05.041

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nanodevices for Studying Nano-pathophysiology2014

    • Author(s)
      *Horacio Cabral, Kanjiro Miyata, *Akihiro Kishimura,
    • Journal Title

      Advanced Drug Delivery Reviews

      Volume: 74 Pages: 35-52

    • DOI

      10.1016/j.addr.2014.06.003

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 高分子ナノテクノロジーを利用した核酸医薬デリバリー2014

    • Author(s)
      宮田完二郎
    • Journal Title

      BIO Clinica

      Volume: 29 Pages: 23-27

    • Related Report
      2014 Annual Research Report
  • [Journal Article] siRNAを用いたDDSの最新情報2014

    • Author(s)
      内藤瑞、宮田完二郎
    • Journal Title

      医薬ジャーナル

      Volume: 50 Pages: 61-65

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 分子レベルの小さな違いを大きな治療成果へとつなぐDDSの開発を目指して2014

    • Author(s)
      宮田完二郎
    • Journal Title

      ドラッグデリバリーシステム

      Volume: 29 Pages: 168-169

    • NAID

      130004495157

    • Related Report
      2013 Annual Research Report
  • [Journal Article] siRNA delivery from triblock copolymer micelles with spatially-ordered compartmants of PEG shell, siRNA-loaded intermediate layer, and hydrophobic core2014

    • Author(s)
      Hyun Jin Kim, Kanjiro Miyata, Takahiro Nomoto, Meng Zheng, Ahram Kim, Xueying Liu, Horacio Cabral, R. James Christie, Nobuhiro Nishiyama, Kazunori Kataoka
    • Journal Title

      Biomaterials

      Volume: 35 Issue: 15 Pages: 4548-4556

    • DOI

      10.1016/j.biomaterials.2014.02.016

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Systemic siRNA delivery to a spontaneous pancreatic tumor model in transgenic mice by PEGylated calcium phosphate hybrid micelles2014

    • Author(s)
      F. Pittella, N. Nishiyama, et al.
    • Journal Title

      J. Control. Release

      Volume: 178 Pages: 18-24

    • DOI

      10.1016/j.jconrel.2014.01.008

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multifunctional polyion complex micelle featuring enhanced stability, targetability, and endosome escapability for systemic siRNA delivery to subcutaneous model of lung cancer2014

    • Author(s)
      Hyun Jin Kim, Takehiko Ishii, Meng Zheng, Sumiyo Watanabe, Kazuko Toh, Yu Matsumoto, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori Kataoka
    • Journal Title

      Drug Delivery and Translational Research

      Volume: 4 Issue: 1 Pages: 50-60

    • DOI

      10.1007/s13346-013-0175-6

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Polymer-based oligonucleotide delivery ~challenges and solutions~2017

    • Author(s)
      K. Miyata
    • Organizer
      11th Annual Symposium on Nanobiotechnology 2017
    • Place of Presentation
      Kawasaki, Japan
    • Year and Date
      2017-02-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ナノマシンによるがん治療研究の最前線2017

    • Author(s)
      宮田完二郎
    • Organizer
      先端ナノデバイス・材料テクノロジー第151委員会
    • Place of Presentation
      川崎 川崎生命科学・環境研究センター
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ユニットPIC/金ナノ粒子 ハイブリッドナノキャリアによる がん標的siRNAデリバリー2016

    • Author(s)
      宮田完二郎、他
    • Organizer
      第26回日本MRS年次大会
    • Place of Presentation
      横浜 横浜市開港記念会館
    • Year and Date
      2016-12-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] Development of smart polymeric nanocarriers for targeted siRNA delivery2016

    • Author(s)
      K. Miyata
    • Organizer
      EPFL/UTokyo Joint Symposium 2016, Lausanne
    • Place of Presentation
      Lausanne, Switzerland
    • Year and Date
      2016-12-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 高分子ナノテクノロジーが切り拓く核酸医薬デリバリー2016

    • Author(s)
      宮田完二郎
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      横浜 パシフィコ横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Smart polymeric nanocarriers for systemic nucleic acid delivery2016

    • Author(s)
      K. Miyata
    • Organizer
      12th Annual Meeting of the Oligonucleotide Therapeutics Society
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ブロック共重合体を用いたsiRNA封入ポリイオンコンプレックスの構造制御とデリバリーへの展開2016

    • Author(s)
      宮田完二郎、他
    • Organizer
      第65回高分子討論会
    • Place of Presentation
      横浜 神奈川大学横浜キャンパス
    • Year and Date
      2016-09-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Ligand-installed polymeric nanocarriers for targeted drug and nucleic acid delivery2016

    • Author(s)
      K. Miyata
    • Organizer
      Drug Carriers in Medicine & Biology in Gordon Research Conference
    • Place of Presentation
      Waterville Valley, USA
    • Year and Date
      2016-08-07
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] リガンド搭載高分子ナノ粒子を用いた 腫瘍組織特異的核酸デリバリー2016

    • Author(s)
      宮田完二郎、他
    • Organizer
      第32回日本DDS学会学術集会
    • Place of Presentation
      静岡 グランシップ
    • Year and Date
      2016-06-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 高分子ナノテクノロジーを基盤とする 核酸医薬デリバリーシステムの開発2016

    • Author(s)
      宮田完二郎
    • Organizer
      岐阜大学大学院連合創薬医療情報研究科公開講座
    • Place of Presentation
      岐阜県 岐阜市 岐阜大学サテライトキャンパス
    • Year and Date
      2016-01-19
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 高分子ナノテクノロジーを基盤とする 核酸医薬デリバリーシステムの開発2016

    • Author(s)
      宮田完二郎
    • Organizer
      マテリアル工学セミナー
    • Place of Presentation
      東京都 文京区 東京大学
    • Year and Date
      2016-01-15
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ナノバイオテクノロジーが先導する 診断・治療イノベーション2016

    • Author(s)
      宮田完二郎
    • Organizer
      GRENE開発講座ナノバイオコース
    • Place of Presentation
      東京都 目黒区 東工大蔵前会館
    • Year and Date
      2016-01-13
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 高分子ナノキャリアを用いた核酸医薬デリバリー2016

    • Author(s)
      宮田完二郎
    • Organizer
      第1回RNA創薬セミナー
    • Place of Presentation
      大阪 大阪医科大学
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Development of Polymeric Materials for Systemic siRNA Delivery to Solid Tumor and Brain2015

    • Author(s)
      K. Miyata, et al
    • Organizer
      Pacifichem 2015
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 高分子ナノテクノロジーによる 核酸医薬デリバリー2015

    • Author(s)
      宮田完二郎、他
    • Organizer
      BMB2015
    • Place of Presentation
      兵庫県 神戸市 神戸ポートアイランド
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 高分子ナノテクノロジーを基盤とする 核酸医薬デリバリー2015

    • Author(s)
      宮田完二郎、他
    • Organizer
      日本核酸医薬学会第1回年会
    • Place of Presentation
      京都府 京都市 京都テルサ
    • Year and Date
      2015-11-30
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 1分子siRNA封入 ユニットポリイオンコンプレックスの精密構造設計2015

    • Author(s)
      宮田完二郎、他
    • Organizer
      第64回高分子討論会
    • Place of Presentation
      宮城県 仙台市 東北大川内キャンパス
    • Year and Date
      2015-09-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] Development of Polymeric Nanocarriers for Targeted siRNA Delivery2015

    • Author(s)
      K. Miyata, et al
    • Organizer
      IUPAC-2015
    • Place of Presentation
      Busan, Korea
    • Year and Date
      2015-08-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Multifunctional polygon complex micelle featuring enhanced stability, targetability, and endosome escapability for systemic siRNA delivery to subcutaneous model of lung cancer2015

    • Author(s)
      K. Miyata, et al
    • Organizer
      42nd CRS Annual Meeting & Exposition
    • Place of Presentation
      Edinburgh, Scotland
    • Year and Date
      2015-07-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 高分子ナノテクノロジーを基盤とする 核酸医薬デリバリーシステムの開発2015

    • Author(s)
      宮田完二郎
    • Organizer
      第31回日本DDS学会学術集会
    • Place of Presentation
      東京都 新宿区 京王プラザホテル
    • Year and Date
      2015-07-03
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] リガンド搭載高分子ミセル型ナノキャリアを用いた組織特異的核酸デリバリー2014

    • Author(s)
      宮田完二郎、他
    • Organizer
      第33回日本認知症学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-29 – 2014-12-01
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Development of small polymeric nano carriers for systemic siRNA delivery to solid tumors2014

    • Author(s)
      Kanjiro Miyata, et al.
    • Organizer
      2014 International Conference of the Korean Society of Pharmaceutical Sciences and Technology
    • Place of Presentation
      ソウル、韓国
    • Year and Date
      2014-11-27 – 2014-11-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 核酸デリバリーのための高分子ナノキャリア設計2014

    • Author(s)
      宮田完二郎
    • Organizer
      第30回日本DDS学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-30 – 2014-07-31
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Development of polymeric nano materials for systemic siRNA delivery to solid tumors2014

    • Author(s)
      Kanjiro Miyata, et al.
    • Organizer
      Frontiers of Polymer Colloids
    • Place of Presentation
      プラハ、チェコ
    • Year and Date
      2014-07-20 – 2014-07-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Development of polymeric nano carriers for systemic siRNA delivery to solid tumors2014

    • Author(s)
      Kanjiro Miyata , et al.
    • Organizer
      Global RNAi Carrier Initiative Symposium
    • Place of Presentation
      ソウル、韓国
    • Year and Date
      2014-05-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Development of nanobiomaterials for tumor-targeted delivery of small nucleic acids2014

    • Author(s)
      宮田完二郎
    • Organizer
      FIRST合同国際シンポジウム
    • Place of Presentation
      札幌パークホテル
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 薬剤・核酸医薬をがんへ送り届ける高分子ナノキャリア2014

    • Author(s)
      宮田完二郎
    • Organizer
      第25回健康医療開発機構ネットワークセミナー
    • Place of Presentation
      東京大学医科学研究所
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 高分子ナノ材料を基盤とする核酸医薬デリバリーシステムの開発2013

    • Author(s)
      宮田完二郎
    • Organizer
      第16回ヒューマンサイエンス総合研究ワークショップ
    • Place of Presentation
      ソラシティカンファレンスセンター
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] siRNA1分子封入ポリイオンコンプレックスの構築とsiRNAデリバリーへの展開2013

    • Author(s)
      宮田完二郎、茶谷洋行、渡邉秀美代、林光太朗、他
    • Organizer
      第35回日本バイオマテリアル学会大会
    • Place of Presentation
      タワーホール船堀
    • Related Report
      2013 Annual Research Report
  • [Presentation] Enhanced nucleic acids delivery by fine-tuning repeated aminoethylene structures in polyaspartamide side chain2013

    • Author(s)
      Kanjiro Miyata, Kazunori Kataoka
    • Organizer
      The 4th Asian Symposium on Advanced Materials
    • Place of Presentation
      台湾科技大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] Development of polymeric nanocarriers for enhanced siRNA delivery toward cancer therapy2013

    • Author(s)
      Kanjiro Miyata, R. J. Christie, Nobuhiro Nishiyama, Kazunori Kataoka
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Design of polymeric nanomaterials for enhanced small RNA delivery2013

    • Author(s)
      Kanjiro Miyata, Kazunori Kataoka
    • Organizer
      15th Asian Chemical Congress 2013
    • Place of Presentation
      Resorts World Sentosa
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 環状RGDペプチドリガンドを装着した高分子ミセル型siRNAキャリアの開発とがん治療への展開2013

    • Author(s)
      宮田完二郎
    • Organizer
      第29回日本DDS学会学術集会
    • Place of Presentation
      京都テルサ
    • Related Report
      2013 Annual Research Report
  • [Presentation] siRNA1分子を封入する微小核酸キャリアの開発2013

    • Author(s)
      宮田完二郎
    • Organizer
      第13回次世代医工学研究会
    • Place of Presentation
      みのお山荘
    • Related Report
      2013 Annual Research Report
  • [Presentation] siRNA1分子を封入する微小核酸キャリアの開発2013

    • Author(s)
      宮田完二郎
    • Organizer
      第6回ナノバイオ若手ネットワーキングシンポジウム
    • Place of Presentation
      富山県民会館
    • Related Report
      2013 Annual Research Report
  • [Book] siRNA delivery methods2016

    • Author(s)
      H. J. Kim, K. Miyata, et al
    • Total Pages
      313
    • Publisher
      Springer
    • Related Report
      2015 Annual Research Report
  • [Book] 核酸医薬の創製と応用展開2016

    • Author(s)
      宮田完二郎、他
    • Total Pages
      278
    • Publisher
      シーエムシー
    • Related Report
      2015 Annual Research Report
  • [Book] Non-viral vectors for gene delivery (Advances in Genetics, volume 88)2014

    • Author(s)
      Hiroyasu Takemoto, Kanjiro Miyata, et al.
    • Total Pages
      271
    • Publisher
      Elsevier
    • Related Report
      2014 Annual Research Report
  • [Book] 最新がん薬物療法学-がん薬物療法の最新知見-2014

    • Author(s)
      宮田完二郎、片岡一則
    • Total Pages
      736
    • Publisher
      日本臨牀社
    • Related Report
      2013 Annual Research Report
  • [Book] 非経口投与製剤の開発と応用-次世代型医薬品の新規投与形態の開拓を目指して-2013

    • Author(s)
      宮田完二郎、片岡一則
    • Total Pages
      257
    • Publisher
      シーエムシー
    • Related Report
      2013 Annual Research Report
  • [Book] Tailored Polymer Architectures for Pharmaceutical and Biomedical Applications2013

    • Author(s)
      Kanjiro Miyata, R. James Christie, et al.
    • Total Pages
      363
    • Publisher
      ACS Publication
    • Related Report
      2013 Annual Research Report
  • [Remarks] 宮田研究室ホームページ

    • URL

      http://www.bmm.t.u-tokyo.ac.jp

    • Related Report
      2016 Annual Research Report
  • [Remarks] 宮田研究室ホームページ

    • URL

      http://www.bmm.t.u-tokyo.ac.jp/index.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 片岡研究室ホームページ

    • URL

      http://www.bmw.t.u-tokyo.ac.jp/index.html

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
  • [Remarks] 臨床医工学部門ホームページ

    • URL

      http://www.cdbim.m.u-tokyo.ac.jp/research/04.php

    • Related Report
      2014 Annual Research Report
  • [Remarks] 東京大学 片岡研究室

    • URL

      http://www.bmw.t.u-tokyo.ac.jp/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 東京大学大学院医学系研究科 疾患生命工学センター 臨床医工学部門

    • URL

      http://www.cdbim.m.u-tokyo.ac.jp/research/04.php

    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2021-01-27  

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