|Budget Amount *help
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2016: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
|Outline of Final Research Achievements
This study aimed to develop an "siRNA carrier" that allows for safe and efficient siRNA delivery to solid tumors. Particularly, a single siRNA-loaded polyion complex, termed unit PIC, was constructed as a smallest delivery formulation featuring high tissue permeability. The obtained results demonstrated that 1) fine-tuning of the chemical structure and chain length of block catiomers enabled the selective formation of unit PICs, and 2) the optimized unit PIC exerted the excellent blood circulation property and tumor accumulation profile, leading to the enhanced antitumor activity.