Real-time detection of HIFU (high-intensity focused ultrasound) induced thermal coaulation by ultrasonic imaging
| Project/Area Number |
25282149
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIZAWA SHIN 東北大学, 大学院工学研究科, 准教授 (30455802)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Keywords | 集束超音波治療 / 熱凝固 / 実時間検出 / 超音波散乱 / 超音波イメージング / 超音波エコー / 相関係数 / 医用超音波工学 / 超音波治療 / 集束超音波 / 加熱凝固 / 後方散乱 / 熱変性 |
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| Outline of Final Research Achievements |
In noninvasive therapy such as HIFU (high-intensity focused ultrasound) treatment, a noninvasive imaging method to aim and monitor the tissue to be treated is essential because the surgeon cannot looked at the tissue by naked eye. Ultrasonic imaging has advantages that the deflection due to non-uniformity in sound speed can be inherently corrected and that real-time imaging can achieved at a relatively low cost, but temperature mapping is significantly more difficult than MRI in principle. Therefore, we looked at the fact that the correlation between ultrasonic echo images before and after thermal coagulation significantly decreases because of the change in backscatter of the tissue. As the result of this study, we succeeded in real-time detection of HIFU-induced thermal coagulation of tissue by real-time mapping of maximum correlation coefficient between the ultrasonic RF images obtained using high-speed ultrasonic imaging.
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Report
(4 results)
Research Products
(53 results)
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[Journal Article] Sonodynamically-induced cytotoxicity by rose bengal derivative and microbubbles in isolated sarcoma 180 cells2015
Author(s)
N. Sugita, M. Hosokawa, M.b, Sunaga, N.b, Iwase, Y.b, Yumita, N.b, Ikeda, T.b, Umemura, S.-I.c
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Journal Title
Japanese Journal of Applied Physics
Volume: 54 (7)
Issue: 7S1
Pages: 07HF16-07HF16
DOI
Related Report
Peer Reviewed
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[Presentation] キャビテーション気泡を援用した集束超音波加熱治療2014
Author(s)
吉澤 晋, 高木 亮, 佐々木 博史, 後藤 功太, 阿部 信隆, 小寺 祥平, 石井 宏志, 鈴木 孝司, 村垣 善浩, 伊関 洋, 梅村 晋一郎
Organizer
第53回日本生体医工学会大会
Place of Presentation
仙台アエル（仙台）
Year and Date
2014-06-24 – 2014-06-26
Related Report
Invited
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[Presentation] 超音波生成したキャビテーション気泡の超音波観察2014
Author(s)
吉澤 晋, 高木 亮, 佐々木 博史, 佐々木 翔也, 阿部 信隆, 小寺 祥平, 村垣 善浩, 伊関 洋, 梅村 晋一郎
Organizer
日本超音波医学会第87回学術集会
Place of Presentation
パシフィコ横浜（横浜）
Year and Date
2014-05-09 – 2014-05-11
Related Report
Invited
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[Presentation] CAVITATION-ENHANCED HEATING IN A LARGE REGION WITH HIGH-SPEED ULTRASONIC IMAGING2014
Author(s)
Shin Yoshizawa, Ryo Takagi, Hiroshi Sasaki, Kota Goto, Nobutaka Abe, Shohei Kodera, Hiroshi Ishii, Takashi Suzuki, Yoshihiro Muragaki, Hirosi Iseki, Shin-ichiro Umemura
Organizer
14th International Symposium on Therapeutic Ultrasound
Place of Presentation
Las Vegas, NV, USA
Year and Date
2014-04-02 – 2014-04-05
Related Report
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