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Development of three dimensional dose evaluation system using prompt gamma-ray for boron neutron capture therapy

Research Project

Project/Area Number 25282155
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Medical systems
Research InstitutionKyoto University

Principal Investigator

Tanaka Hiroki  京都大学, 原子炉実験所, 准教授 (70391274)

Co-Investigator(Kenkyū-buntansha) 櫻井 良憲  京都大学, 原子炉実験所, 准教授 (20273534)
川端 信司  大阪医科大学, 医学部, 講師 (20340549)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2013: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Keywordsホウ素中性子捕捉療法 / リアルタイムホウ素濃度測定 / がん治療 / 線量評価システム / SPECT / 硼素中性子捕捉両方 / 線量評価 / 光ファイバー / 硼素中性子捕捉療法
Outline of Final Research Achievements

Generally, boron concentration is measured by the method of prompt gamma ray analysis in BNCT treatment. However, the information of boron concentration is not able to be obtained by this method during the treatment. It is desired to measure the boron concentration in real-time. Therefore, we propose the method using prompt gamma rays with the energy of 478 keV emitted by the reaction between boron-10 and thermal neutron. There are some agendas, which should be overcome in order to apply a prompt gamma rays imaging detector in BNCT irradiation field. Most important agenda is the discrimination from 511 keV annihilation gamma ray as back-ground. The energy resolution of less than 6.5 % FWHM at 511 keV is needed in order to discriminate 511 keV gamma ray.
We constructed a prompt gamma rays imaging detector consisting of LaBr3(Ce) scintillator, 8 x 8 MPPC arrays, 64 channel channels amplifier and ADC. It was confirmed that this system was able to discriminate 511 keV gamma ray.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (29 results)

All 2017 2016 2015 2014 2013

All Journal Article (5 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (21 results) (of which Int'l Joint Research: 4 results,  Invited: 3 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Comparison of the pharmacokinetics between L-BPA and L-FBPA using the same administration dose and protocol: a validation study for the theranostic approach using [18F]-L-FBPA positron emission tomography in boron neutron capture therapy2016

    • Author(s)
      Tsubasa Watanabe, Yoshihide Hattori, Youichiro Ohta, Miki Ishimura, Yosuke Nakagawa, Yu Sanada, Hiroki Tanaka, Satoshi Fukutani, Shin-ichiro Masunaga, Masahiro Hiraoka, Koji Ono, Minoru Suzuki, Mitsunori Kirihata
    • Journal Title

      BMC Cancer

      Volume: 16 Issue: 1 Pages: 859-868

    • DOI

      10.1186/s12885-016-2913-x

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] ホウ素中性子捕捉療法(BNCT)の現状について2015

    • Author(s)
      田中浩基、櫻井良憲、鈴木実、増永慎一郎、丸橋晃、小野公二
    • Journal Title

      放射線

      Volume: 41-3 Pages: 119-125

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Evaluation of thermal neutron irradiation field using a cyclotron-based neutron source for alpha autoradiography2014

    • Author(s)
      Tanaka H, Sakurai Y, Suzuki M, Masunaga S, et al. 計13名
    • Journal Title

      Appl.Radiat.Isotopes

      Volume: 88 Pages: 153-156

    • DOI

      10.1016/j.apradiso.2014.01.011

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dose estimation for internal organs during boron neutron capture therapy for body-trunk tumors2014

    • Author(s)
      Sakurai Y, Tanaka H, Suzuki M, Masunaga S, et al. 計8名
    • Journal Title

      Appl.Radiat.Isotopes

      Volume: 88 Pages: 43-45

    • DOI

      10.1016/j.apradiso.2014.03.005

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a simple and rapid method of precisely identifying the position of ^<10>B atoms in tissue : an improvement in standard alpha autoradiography2013

    • Author(s)
      Tanaka H, Sakurai Y, Suzuki M, Masunaga S, Takamiya K, Maruhashi A, Ono K
    • Journal Title

      J Radiat Res

      Volume: 56 Issue: 2 Pages: 373-380

    • DOI

      10.1093/jrr/rrt110

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Real time measurement of 10-boron concentration in the liver using gamma-telescope2016

    • Author(s)
      M. Suzuki,Y.Sakurai,H.Tanaka,T.Takata,T.Watanabe,N.Kondo,S.Masunaga,Y.Kinashi,A.Maruhashi,K.Ono
    • Organizer
      日本放射線腫瘍学会第29回学術大会
    • Place of Presentation
      京都国際会議場(京都府京都市)
    • Year and Date
      2016-11-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] Design and Feasibility of a Gamma-Ray Detection System for Three Dimensional Patient Dose Imaging2016

    • Author(s)
      K. Akabori, K. Taki, Y. Aoki, T. Mitsumoto, S. Yajima, H. Tanaka
    • Organizer
      the 17th International Congress on Neutron Capture Therapy
    • Place of Presentation
      Missiuri,USA
    • Year and Date
      2016-10-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinical results of reactor-based BNCT using BPA for the patients with recurrent malignant glioma2016

    • Author(s)
      S. Kawabata, R. Hiramatsu, K. Takeuchi, H. Shiba, Y. Matsushita, T.Kuroiwa, H. Tanaka, Y. Sakurai, M. Suzuki, K. Ono, S.-I. Miyatake
    • Organizer
      the 17th International Congress on Neutron Capture Therapy
    • Place of Presentation
      Missiuri,USA
    • Year and Date
      2016-10-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of a real-time prompt gamma-ray imaging system using GAGG:Ce or SrI2:Eu scintillator array for BNCT2016

    • Author(s)
      H.Tanaka, Y. Sakurai, T. Takata, T. Watanabe, M. Suzuki, K. Akabori, S. Kawabata, S. Masunaga, N. Kondo, K. Ono, A. Maruhashi
    • Organizer
      the 17th International Congress on Neutron Capture Therapy
    • Place of Presentation
      Missiuri,USA
    • Year and Date
      2016-10-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 最近のBNCTの物理・技術的動向について2016

    • Author(s)
      田中浩基
    • Organizer
      2016年医学物理講習会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2016-09-08
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] BNCTのためのシンチレータアレイを用いた即発ガンマ線検出器の開発2016

    • Author(s)
      田中浩基、櫻井良憲、高田卓志、鈴木実、 増永慎一郎、赤堀清崇、丸橋晃、小野公二
    • Organizer
      第112回日本医学物理学会学術大会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2016-09-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] SrI2(Eu)シンチレータを用いた即発ガンマ線検出器の開発2016

    • Author(s)
      田中浩基、櫻井良憲、高田卓志、渡邉翼、鈴木実、増永慎一郎、川端信司、赤堀清崇、丸橋晃、小野公二、
    • Organizer
      第13回日本中性子捕捉療法学会学術大会
    • Place of Presentation
      東京大学(東京都文京区)
    • Year and Date
      2016-08-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] BNCTのための リアルタイム線量評価システムの開発2016

    • Author(s)
      田中浩基、櫻井良憲、高田卓志、鈴木実、 増永慎一郎、渡邉翼、近藤夏子、赤堀清崇 丸橋晃、小野公二
    • Organizer
      第54回日本放射線腫瘍学会生物部会学術大会
    • Place of Presentation
      I-siteなんば(大阪府大阪市)
    • Year and Date
      2016-07-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] BNCTのための即発ガンマ線を用いたホウ素濃度モニターの開発2016

    • Author(s)
      田中 浩基,櫻井 良憲、高田 卓志、鈴木 実、増永 慎一郎、赤堀 清崇、丸橋 晃、小野 公二
    • Organizer
      日本原子力学会2016年春の年会
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] ホウ素中性子捕捉療法のための サイクロトロンを用いた 加速器中性子源2015

    • Author(s)
      田中浩基
    • Organizer
      第58回放射線科学研究会
    • Place of Presentation
      住友クラブ(大阪府大阪市)
    • Year and Date
      2015-10-16
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 即発ガンマ線を用いたリアルタイムホウ素濃度モニターの開発2015

    • Author(s)
      田中 浩基、櫻井 良憲、高田 卓志、藤本 望、渡邉 翼、滝 和也、鈴木 実、増永慎一郎、丸橋 晃、小野 公二
    • Organizer
      第12回日本中性子捕捉療法学会学術大会
    • Place of Presentation
      神戸学院大学(兵庫県神戸市)
    • Year and Date
      2015-09-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] ホウ素中性子捕捉療法(BNCT)の 現状について2015

    • Author(s)
      田中浩基
    • Organizer
      第27回放射線夏の学校
    • Place of Presentation
      和歌山 和歌の浦温泉 萬波(和歌山県和歌山市)
    • Year and Date
      2015-08-04
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Development of a boron distribution monitor using prompt gamma-rays for boron neutron capture therapy2015

    • Author(s)
      H. Tanaka, Y. Sakurai, T. Takata, M. Suzuki, S. Masunaga, A. Maruhashi, K. Ono
    • Organizer
      2015 World Congress on Medical Physics and Biomedical Engineering
    • Place of Presentation
      Tront, Canada
    • Year and Date
      2015-06-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of a real-time dosimeter for boron neutron capture therapy2014

    • Author(s)
      Hiroki Tanaka, Yoshinori Sakurai, Minoru Suzuki, Shin-Ichiro Masunaga, Takushi Takata, Nozomi Fujimoto, Kazuya Taki, Akira Maruhashi, Koji Ono
    • Organizer
      The 7th Korea-Japan Joint Meeting on Medical Physics
    • Place of Presentation
      Pusan Korea
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 微小シンチレータと石英ファイバーを用いた中性子モニターのBNCT照射場への適応2014

    • Author(s)
      田中浩基,櫻井良憲,鈴木実,増永慎一郎,高田卓志,藤本望,仲川洋介,渡邉翼,近藤夏子,楢林正流,木梨友子,滝和也,小野公二,丸橋晃
    • Organizer
      第11回日本中性子捕捉療法学会学術大会
    • Place of Presentation
      大阪大学(大阪府吹田市)
    • Year and Date
      2014-07-05 – 2014-07-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Study on the accelerator-based neutron source using Be(p,n) reaction with proton energy of lower than 30 MeV2014

    • Author(s)
      Hiroki Tanaka, Yoshinori Sakurai, Minoru Suzuki, Shin-ichiro Masunaga, Nozomi Fujimoto, Yuko Kinashi, Natsuko Kondo, Takushi Takata, Masaru Narabayashi, Tsubasa Watanabe, Akira Maruhashi and Koji Ono
    • Organizer
      16th International Congress on Neutron Capture Therapy
    • Place of Presentation
      Helsinki, Finland
    • Year and Date
      2014-06-14 – 2014-06-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Prospect BNCT in The World and Experience of BNCT by KUR and Start of Clinical BNCT Trial by Small Cyclotron Based Neutron Generator in KURRI.2014

    • Author(s)
      Hiroki Tanaka
    • Organizer
      Annual National Conference on Prospect of Science and Technology Accelerator for Health, Industry and Environment
    • Place of Presentation
      Yogyakarta Indonesia
    • Year and Date
      2014-06-09 – 2014-06-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] ホウ素中性子捕捉療法における多門照射による深部線量分布改善に関する研究2013

    • Author(s)
      藤本 望、田中浩基、櫻井良憲、小野公二、鈴木実
    • Organizer
      第10回日本中性子捕捉療法学会
    • Place of Presentation
      岡山大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] BNCTのための陽子線による即発ガンマ線分析法を用いたホウ素濃度測定に関する研究2013

    • Author(s)
      田中浩基、櫻井良憲、内田良平、川村徳寛、鈴木実、増永慎一郎、土田秀次、小野公二、丸橋晃
    • Organizer
      第106回日本医学物理学会
    • Place of Presentation
      大阪大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] アルファオートラジオグラフィの高度化に関する研究2013

    • Author(s)
      田中浩基、櫻井良憲、鈴木実、増永慎一郎、木梨友子、近藤夏子、楢林正流、藤本望、渡邉翼、仲川洋介、丸橋晃、小野公二
    • Organizer
      平成25年度京大炉専門研究会
    • Place of Presentation
      京都大学原子炉実験所
    • Related Report
      2013 Annual Research Report
  • [Presentation] Study on the evaluation of 10B concentration using proton-induced prompt gamma ray analysis for BNCT2013

    • Author(s)
      Hiroki Tanaka, Yoshinori Sakurai, Ryohei Uchida, Tokuhiro Kawamura, Tsubasa Watanabe, Minoru Suzuki,Hidetsugu Tsutida,Shinichiro Masunaga, Natsuko Kondo, Masaru Narabayashi,Koji Ono, Akira Maruhashi
    • Organizer
      7th Young Researchers Boron Neutron Capture Therapy Meeting
    • Place of Presentation
      スペイン、グラナダ
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 中性子捕捉療法システム及び中性子捕捉療法用ガンマ線検出器2017

    • Inventor(s)
      赤堀清崇、田中浩基
    • Industrial Property Rights Holder
      赤堀清崇、田中浩基
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-066025
    • Filing Date
      2017-03-29
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] 中性子捕捉療法システム2015

    • Inventor(s)
      武川哲也 滝和也、田中浩基
    • Industrial Property Rights Holder
      武川哲也 滝和也、田中浩基
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-212993
    • Filing Date
      2015-10-29
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 中性子捕捉療法装置2015

    • Inventor(s)
      酒井文雄、田中浩基
    • Industrial Property Rights Holder
      住友重機械工業株式会社、京都大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-043840
    • Filing Date
      2015-03-05
    • Related Report
      2014 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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