| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
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| Outline of Final Research Achievements |
Myofascial pain such as stiff neck, low back pain, and fibromyalgia is frequent in our aging society, and it is deeply affected by physical and mental stress. Here in this study we clarified some molecular and neural mechanisms of stress-induced myofascial pain (SiMFP) using animal models. In a reserpine-induced fibromyalgia model, acid-sensing ion channel 3 expressing in peripheral nociceptive neurons and spinal microglia play pivotal roles in mechanical hyperalgesia. ASIC3 was found to be involved in exercise-induced myofascial pain by behavioral and electrophysiological experiments. These findings could be useful for the treatment of patients with SiMFP.
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