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Role of innervation in the control of bone remodeling in aged and disused musculoskeletal atrophy

Research Project

Project/Area Number 25282163
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionNiigata University of Health and Welfare

Principal Investigator

YAMAMOTO NORIAKI  新潟医療福祉大学, ロコモティブ症候群予防研究センター, 副センター長 (30445902)

Co-Investigator(Kenkyū-buntansha) 大西 秀明  新潟医療福祉大学, 医療技術学部, 教授 (90339953)
田巻 弘之  新潟医療福祉大学, 医療技術学部, 教授 (40253926)
桐本 光  新潟医療福祉大学, 医療技術学部, 教授 (40406260)
與谷 謙吾  鹿屋体育大学, その他部局等, 講師 (10581142)
高橋 英明  新潟医療福祉大学, 医療技術学部, 助教 (90636250)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Keywords加齢 / 骨リモデリング / 神経 / 萎縮 / 骨代謝 / 老化 / 高齢期 / 運動 / 不動
Outline of Final Research Achievements

Bone tissue is innervated by peripheral nerves, and the nervous system controls bone remodeling by regulating bone formation and resorption. We investigated the influence of the nervous system on the histomorphometric parameters of bone tissue, the mechanical properties of tibiae cortical bone, the three-dimensional architecture of trabecular, and cortical bone using micro-CT in aged and disused musculoskeletal atrophy.
The bone volume fraction, bone strength, bone formation of osteoblasts, and the number of osteoid-osteocytes were decreased by functional denervation. Treatment of β-adrenoceptor blockers ameliorated osteoporosis characterized by low bone volume and microarchitectural deterioration of bone tissue in old, spontaneously hypertensive rats (SHR), which have an elevated sympathetic tone at rest.
The results provide evidence for the positive and negative influences of the nervous system on bone remodeling in age-related and disuse osteoporosis.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (31 results)

All 2017 2016 2015 2014 2013 Other

All Journal Article (16 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 4 results,  Acknowledgement Compliant: 5 results) Presentation (15 results) (of which Invited: 4 results)

  • [Journal Article] Atypical femoral fracture and bisphosphonate.2017

    • Author(s)
      Yamamoto N
    • Journal Title

      Clin Calcium

      Volume: 22 Pages: 233-238

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Electrical stimulation of denervated rat skeletal muscle ameliorates bone fragility and muscle loss in early-stage disuse musculoskeletal atrophy2017

    • Author(s)
      Tamaki H, Yotani K, Ogita F, Hayao K, Nakagawa K, Sugawara K, Kirimoto H, Onishi H, Kasuga N, Yamamoto N
    • Journal Title

      Calcif Tissue Int

      Volume: 100 Issue: 4 Pages: 420-430

    • DOI

      10.1007/s00223-017-0250-y

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Articular chondrocyte alignment in the rat after surgically induced osteoarthritis2017

    • Author(s)
      Takahashi H, Tamaki H, Yamamoto N, Onishi H
    • Journal Title

      Journal of Physical Therapy Science

      Volume: 29 Issue: 4 Pages: 598-604

    • DOI

      10.1589/jpts.29.598

    • NAID

      130006789342

    • ISSN
      0915-5287, 2187-5626
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Time-dependent changes in the structure of calcified fibrocartilage in the rat Achilles tendon-bone interface with sciatic denervation.2017

    • Author(s)
      Takahashi H, Tamaki H, Oyama M,Yamamoto N, Onishi H
    • Journal Title

      Anat Rec

      Volume: 300

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 大腿骨近位部骨折の疫学2016

    • Author(s)
      山本智章
    • Journal Title

      MEDICAL REHABILITATION

      Volume: 197 Pages: 1-4

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Bone histomorphometry;A role of evaluation for bone quality and mechanical strength.2016

    • Author(s)
      Yamamoto N, Takahashi H, Shimakura T.
    • Journal Title

      Clin Calcium

      Volume: 26 Pages: 9-15

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Incidence of hip fracture in Niigata, Japan in 2004 and 2010 and the long term trends from 1985-2010.2016

    • Author(s)
      Miyasaka D., Endo N., Endo E., Sakuma M., Yamamoto N., Tanabe N., Imai N., Suda K.
    • Journal Title

      J Bone Miner Metab.

      Volume: 34 Issue: 1 Pages: 92-98

    • DOI

      10.1007/s00774-015-0648-4

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of electrical stimulation-induced muscle force and streptomycin treatment on muscle and trabecular bone mass in early-stage disuse musculoskeletal atrophy.2015

    • Author(s)
      Tamaki H, Yotani K, Ogita F, Sugawara K, Kirimto H, Onishi H, Kasuga N, Yamamoto N.
    • Journal Title

      J Musculoskelet Neuronal Interact

      Volume: 15 Pages: 270-278

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Bone Cell Biology Assessed by Microscopic Approach. Bone histomorphometry of remodeling, modeling and minimodeling.2015

    • Author(s)
      Yamamoto N, Shimakura T, Takahashi H.
    • Journal Title

      Clin Calcium

      Volume: 25 Pages: 1491-1497

    • Related Report
      2015 Annual Research Report
  • [Journal Article] アンチエイジングのためのスポーツ 骨代謝改善に果たすスポーツの役割2014

    • Author(s)
      山本智章
    • Journal Title

      日本整形外科スポーツ医学会雑誌

      Volume: 34 Pages: 239-242

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 脆弱性骨折における現状の問題点と海外での取り組み2014

    • Author(s)
      山本智章
    • Journal Title

      整形外科

      Volume: 65 Pages: 730-734

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Electrical stimulation of denervated rat skeletal muscle retards trabecular bone loss in early stages of disuse musculoskeletal atrophy.2014

    • Author(s)
      Tamaki H, Tomori K, Yotani K, Ogita F, Sugawara K, Kirimto H, Onishi H, Yamamoto N, Kasuga N.
    • Journal Title

      J Musculoskelet Neuronal Interact.

      Volume: 14 Pages: 220-228

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The changes of bone architecture in atypical femoral fracture2013

    • Author(s)
      Yamamoto N, Shimakura T, Takahash H.
    • Journal Title

      Clin Calcium

      Volume: 23 Pages: 976-971

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 非定型骨折の病態とその対応 Severely Suppressed Bone Turnoverによる非定型骨折の組織学的な検討2013

    • Author(s)
      山本智章, 島倉剛俊, 高橋榮明, 遠藤直人
    • Journal Title

      Osteoporosis Japan

      Volume: 21 Pages: 330-333

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 薬物療法による大腿骨近位部骨折の予防2013

    • Author(s)
      山本智章
    • Journal Title

      運動器リハビリテーション

      Volume: 24 Pages: 2-6

    • NAID

      10031181288

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Changes over time in structural plasticity of trabecular bone in rat tibiae immobilized by reversible sciatic denervation.2013

    • Author(s)
      Tamaki H, Yotani K, Ogita F, Takahashi H, Kirimoto H, Onishi H, Yamamoto N
    • Journal Title

      J Musculoskelet Neuronal Interact

      Volume: 13 Pages: 251-258

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 骨形態計測ルネッサンス2016

    • Author(s)
      山本智章
    • Organizer
      日本骨形態計測学会
    • Place of Presentation
      新潟コンベンションセンター
    • Year and Date
      2016-06-23
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 骨形態計測法とin vivoイメージングによる脛骨皮質骨内骨小腔の比較解析2016

    • Author(s)
      佐野博繁, 近藤 直樹, 島倉 剛俊, 藤澤 純一, 木島 靖文, 金井 朋毅, 山本 智章, 高橋 榮明, 遠藤 直人
    • Organizer
      日本骨形態計測学会
    • Place of Presentation
      新潟コンベンションセンター
    • Year and Date
      2016-06-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] 健康長寿を目指したロコモティブシンドロームとフレイル研究 ロコモからみた骨粗鬆症への対応2016

    • Author(s)
      山本智章
    • Organizer
      日本老年医学会
    • Place of Presentation
      金沢
    • Year and Date
      2016-06-08
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 高齢期における不動性骨萎縮に対する電気刺激誘発性筋収縮の効果.2015

    • Author(s)
      田巻弘之,與谷謙吾,荻田 太,中川弘毅,桐本 光,大西秀明,山本智章,春日規克
    • Organizer
      日本基礎理学療法学会第20回学術大会,
    • Place of Presentation
      横須賀
    • Year and Date
      2015-11-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] 不動初期の電気刺激誘発性筋収縮が脛骨骨幹部の力学的特性に及ぼす影響.2015

    • Author(s)
      松永拓朗,田巻弘之,中川弘毅,早尾啓志,與谷謙吾,荻田 太,山本智章,大西秀明
    • Organizer
      日本基礎理学療法学会第20回学術大会,
    • Place of Presentation
      横須賀
    • Year and Date
      2015-11-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] 伸張性筋収縮及びstreptomycin投与の脛骨骨量並びに三次元骨梁構造に及ぼす影響.2015

    • Author(s)
      中川弘毅,田巻弘之,早尾啓志,與谷謙吾,荻田 太,山本智章,大西秀明
    • Organizer
      日本基礎理学療法学会第20回学術大会,
    • Place of Presentation
      横須賀
    • Year and Date
      2015-11-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] 下肢不動ラットにおける脛骨骨幹部の力学的特徴と筋電気刺激の効果.2015

    • Author(s)
      田巻弘之,與谷謙吾,荻田 太,中川弘毅,桐本 光,大西秀明,春日規克
    • Organizer
      第70回日本体力医学会大会
    • Place of Presentation
      和歌山
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 大腿骨近位部骨折治療における骨粗鬆症リエゾン制度の運用と課題2015

    • Author(s)
      山本智章
    • Organizer
      第88回日本整形外科学会
    • Place of Presentation
      神戸
    • Year and Date
      2015-05-23
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 低頻度電気刺激誘発性筋収縮が不動初期の筋毛細血管の形態に及ぼす効果.2014

    • Author(s)
      中川弘毅,田巻弘之,荻田 太,山本智章,大西秀明
    • Organizer
      第4回日本基礎理学療法学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-11-15 – 2014-11-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] 高齢ラットの廃用性骨量低下を軽減する筋電気刺激の効果2014

    • Author(s)
      田巻 弘之, 與谷謙吾, 荻田 太, 桐本 光, 大西秀明, 山本智章, 春日規克
    • Organizer
      第69回日本体力医学会大会
    • Place of Presentation
      長崎
    • Year and Date
      2014-09-19 – 2014-09-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Streptomycin inhibits effects of electrical stimulation-induced muscle force on reducing disused bone loss.2014

    • Author(s)
      Tamaki H, Yotani K, Kirimoto H, Sugawara K, Tsubaki A, Onishi H, Yamamoto N, Kasuga N
    • Organizer
      2014 Annual Meeting of American Society for Bone and Mineral Research
    • Place of Presentation
      Houston
    • Year and Date
      2014-09-12 – 2014-09-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] 骨リモデリングから考える骨粗鬆症治療のあり方2014

    • Author(s)
      山本智章
    • Organizer
      日本骨形態計測学会
    • Place of Presentation
      札幌
    • Year and Date
      2014-06-12 – 2014-06-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Electrical stimulation of denervated rat skeletal muscle slows trabecular bone loss in early stages of disuse atrophy2013

    • Author(s)
      Tamaki H, Tomori K, Yotani K, Ogita F, Takahashi H, Kirimoto H, Onishi H, Yamamoto N, Kasuga N
    • Organizer
      2nd Joint Meeting of the International Bone and Mineral Society
    • Place of Presentation
      Kobe
    • Related Report
      2013 Annual Research Report
  • [Presentation] アンチエイジングのためのスポーツ 骨代謝改善に果たすスポーツの役割2013

    • Author(s)
      山本智章
    • Organizer
      日本整形外科スポーツ医学会雑誌
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] Denervationがアキレス腱enthesisの石灰化軟骨層構造変化に及ぼす影響.

    • Author(s)
      高橋英明, 田巻弘之, 菅原和広, 大西秀明
    • Organizer
      第3回日本基礎理学療法学術大会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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