The role of microRNAs in mechanical stress-induced muscle adaptation
| Project/Area Number |
25282198
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
AKIMOTO Takayuki 東京大学, 医学(系)研究科(研究院), 講師 (00323460)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Keywords | 筋線維タイプ / 転写後制御 / ノンコーディングRNA / 可塑性 / メカニカルストレス / Dicer / microRNA / 遅筋 / 速筋 / ミトコンドリア / マイクロRNA / 骨格筋 / 適応 |
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| Outline of Final Research Achievements |
We investigated the role of microRNA on mechanical stress-induced muscle adaptation by using Dicer1 knock-out mice (Dicer1 KO). As a result, the muscle-specific Dicer1KO mice died by 6 weeks due to dysfunction of muscles, suggesting that microRNAs in muscle play important roles in homeostasis of muscles.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Regulation of miRNAs in human skeletal muscle following acute endurance exercise and short term endurance training.2013
Author(s)
A. P. Russell, S. Lamon, H. Boon, S. Wada, I. Guller, E. L. Brown, A. V. Chibalin, J. Zierath, R. J. Snow, N. K. Stepto, G. D. Wadley, T. Akimoto.
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Journal Title
J Physiol
Volume: 591
Pages: 4637-4653
Related Report
Peer Reviewed
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