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Comprehensive study on cancer preventive effect of the myokine SPARC and its application for exercise prescription

Research Project

Project/Area Number 25282199
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Sports science
Research InstitutionKyoto Prefectural University

Principal Investigator

Aoi Wataru  京都府立大学, 生命環境科学研究科(系), 助教 (60405272)

Co-Investigator(Kenkyū-buntansha) NAITO YUJI  京都府立医科大学, 医学研究科, 准教授 (00305575)
TAKAGI TOMOHISA  京都府立医科大学, 医学研究科, 准教授 (70405257)
SAKUMA KUNIHIRO  豊橋技術科学大学, 工学部, 准教授 (60291176)
Co-Investigator(Renkei-kenkyūsha) TANIMURA YUKO  愛知東邦大学, 人間学部, 助教 (90551458)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Keywordsマイオカイン / 大腸がん / 運動 / 骨格筋 / がん予防 / 大腸
Outline of Final Research Achievements

SPARC is one of myokines, bioactive proteins secreted from skeletal muscle. The level of circulating SPARC is increased in response to exercise, and contributes to prevention of colon carcinogenesis by habitual exercise.
Our results showed that SPARC directly affects the lesion site of the colon, and prevents carcinogenesis. In addition, the SPARC could increase metabolic capacity of skeletal muscle itself, leading to improved whole body metabolism, which also contributes to the suppression of colon carcinogenesis. The increase of circulating SPARC was found in both healthy subjects and metabolic patients. In addition, dietary approach has been suggested to accelerate the secretion of SPARC efficiently.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (29 results)

All 2015 2014 2013 Other

All Int'l Joint Research (1 results) Journal Article (10 results) (of which Peer Reviewed: 8 results,  Open Access: 5 results,  Acknowledgement Compliant: 3 results) Presentation (15 results) (of which Int'l Joint Research: 6 results,  Invited: 6 results) Book (3 results)

  • [Int'l Joint Research] Karolinska Institutet(Sweden)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Frontier impact of microRNAs in skeletal muscle research: a future perspective.2015

    • Author(s)
      Wataru Aoi
    • Journal Title

      Front Physiol

      Volume: 5:495 Pages: 1-5

    • DOI

      10.3389/fphys.2014.00495

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Milk casein hydrolysate alleviates muscle soreness and fatigue after downhill walking in middle-aged to elderly men2015

    • Author(s)
      Iwasa M, Aoi W, Nakayama A, Wada S, Miyazaki H, Nakamura T, Ohki K, Higashi A
    • Journal Title

      Annals of Sports Medicine and Research

      Volume: 2

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 疾患別からみた生活習慣とがん:大腸がん2015

    • Author(s)
      青井 渉
    • Journal Title

      成人病と生活習慣病-特集 生活習慣とがん

      Volume: 45 Pages: 1248-1252

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Low pH of interstitial fluid around hippocampus of the brain in diabetic OLETF rats2014

    • Author(s)
      Yoshinori Marunaka, Kanji Yoshimoto, Wataru Aoi, Shigekuni Hosogi, Hiroshi Ikegaya
    • Journal Title

      Molecular and Cellular Therapies

      Volume: 2:6 Issue: 1 Pages: 1-4

    • DOI

      10.1186/2052-8426-2-6

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Importance of pH homeostasis in metabolic health and diseases: crucial role of membrane proton transport2014

    • Author(s)
      Wataru Aoi, Yoshinori Marunaka
    • Journal Title

      Biomed Res Int

      Volume: 2014:598986 Pages: 1-8

    • DOI

      10.1155/2014/598986

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 日常的運動による大腸癌予防:新規マイオカインSPARCの発見とその意義2014

    • Author(s)
      内藤裕二,青井渉,髙木智久
    • Journal Title

      消化器内科

      Volume: 58 Pages: 594-598

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Ingenious function of skeletal muscle as a secretory organ: Its crucial role for cancer prevention2014

    • Author(s)
      Wataru Aoi
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 3 Issue: 2 Pages: 211-215

    • DOI

      10.7600/jpfsm.3.211

    • NAID

      130004626098

    • ISSN
      2186-8123, 2186-8131
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The astaxanthin-induced improvement in lipid metabolism during exercise is mediated by a PGC-1α increase in skeletal muscle2014

    • Author(s)
      Po Hung Liu, Wataru Aoi, Maki Takami, Hitomi Terajima, Yuko Tanimura, Yuji Naito, Yoshito Itoh, Toshikazu Yoshikawa
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 54 Issue: 2 Pages: 86-89

    • DOI

      10.3164/jcbn.13-110

    • NAID

      130004879351

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Does regulation of skeletal muscle function involve circulating microRNAs?2014

    • Author(s)
      Wataru Aoi, Kunihiro Sakuma
    • Journal Title

      Frontiers in Physiology

      Volume: 5

    • DOI

      10.3389/fphys.2014.00039

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Possibility of the novel myokine SPARC: A mechanistic approach to colon cancer prevention by physical exercise2013

    • Author(s)
      青井渉
    • Journal Title

      Japanese Journal of Physical Fitness and Sports Medicine

      Volume: 62 Issue: 4 Pages: 263-271

    • DOI

      10.7600/jspfsm.62.263

    • NAID

      10031179339

    • ISSN
      0039-906X, 1881-4751
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] The potential role of dietary antioxidants for metabolic improvement and performance boost2015

    • Author(s)
      Aoi W
    • Organizer
      6th International Conference on Food Factors
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The myokine SPARC improves glucose metabolism via AMPK in skeletal muscle2015

    • Author(s)
      Aoi W, Lassiter DG, Bjornholm M, Chibalin AV, Zierath JR, Krook A
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology-Diabetes: New insights into molecular mechanisms and therapeutic strategies
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2015-10-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The AMP-analogue AICAR acutely reduces cytokine transcription in human skeletal muscle2015

    • Author(s)
      Nylen C, Aoi W, Lassiter DG, Naslund E, Zierath JR, Krook A
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology-Diabetes: New insights into molecular mechanisms and therapeutic strategies
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2015-10-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マイオカイン研究の新展開:代謝-発がん制御システムとしての可能性2015

    • Author(s)
      青井 渉
    • Organizer
      第70回日本体力医学会大会
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] The effect of voluntary exercise on the composition of gut microbiola in mice2015

    • Author(s)
      Tanimura Y, Aoi W, Naito Y, Takagi T, Mizushima K, Higashimura Y, Yoshikawa T
    • Organizer
      20th Annual Congress of the European College of Sport Science
    • Place of Presentation
      Malmo, Sweden
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Profiles of muscle-enriched microRNAs in response to acute and chronic exercise in young men2015

    • Author(s)
      Aoi W, Ichikawa H, Wada S, Higashi A
    • Organizer
      12th Asian Congress of Nutrition
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2015-05-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of increased glutathione-binding protein in human plasma after supplementation of glutathione2015

    • Author(s)
      Shirako S, Wada S, Aoi W, Park EY, Nakamura Y, Sato K
    • Organizer
      12th Asian Congress of Nutrition
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2015-05-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 運動による腸への刺激2014

    • Author(s)
      谷村祐子, 青井渉, 内藤裕二, 高木智久, 水島かつら, 東村泰希, 吉川 敏一
    • Organizer
      第69回日本体力医学会大会
    • Place of Presentation
      長崎
    • Year and Date
      2014-09-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Potential benefit of glutathione supplementation in sports field: Prevention of exercise-induced muscle fatigue2014

    • Author(s)
      Kenji Sato, Wataru Aoi
    • Organizer
      248th the American Chemical Society National Meeting & Exposition
    • Place of Presentation
      SanFrancisco, USA
    • Year and Date
      2014-08-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Glutathione intake improves muscle fatigue induced by exercise associated with increasing PGC-1α2014

    • Author(s)
      Wataru Aoi, Yumi Ogaya, Maki Takami, Toru Konishi, Yusuke Sauchi, Eun Young Park, Sayori Wada, Kenji Sato
    • Organizer
      61th Annual Meeting of the American College of Sports Medicine
    • Place of Presentation
      Frolida, USA
    • Year and Date
      2014-05-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] A muscle-secreted protein SPARC suppresses colon tumorigenesis via apoptotic effect2014

    • Author(s)
      Wataru Aoi
    • Organizer
      6th Annual SRP Diabetes-EndoMet Retreat
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2014-05-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] The effect of SPARC on insulin-sensitive glucose metabolism in skeletal muscle2013

    • Author(s)
      Nariyuki Hirano, Wataru Aoi, Maki Takami, Airi Nakayama, Yumi Ogaya, Sayori Wada, Akane Higashi
    • Organizer
      20th International Congress of Nutrition
    • Place of Presentation
      Granada, Spain
    • Related Report
      2013 Annual Research Report
  • [Presentation] Light exercise after high-fat meal suppresses postprandial serum triglyceride in humans2013

    • Author(s)
      Wataru Aoi, Haruka Yamauchi, Sayori Wada, Akane Higashi
    • Organizer
      20th International Congress of Nutrition
    • Place of Presentation
      Granada, Spain
    • Related Report
      2013 Annual Research Report
  • [Presentation] マイオカインSPARCは運動による大腸がん予防に寄与する2013

    • Author(s)
      青井渉
    • Organizer
      第12回Hindgut Club Japanサテライトミーティング
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 身体活動・運動による発がん予防機構の解明にむけて2013

    • Author(s)
      青井渉
    • Organizer
      第64回日本体育学会大会
    • Place of Presentation
      滋賀
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] 別冊医学のあゆみ:レドックスUPDATE-ストレス制御の臨床医学・健康科学2015

    • Author(s)
      青井 渉
    • Total Pages
      344
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2015 Annual Research Report
  • [Book] Nutraceuticals and Functional Foods in Human Health and Disease Prevention2015

    • Author(s)
      Aoi W, Naito Y
    • Total Pages
      700
    • Publisher
      CRC Press, Taylor & Francis Group
    • Related Report
      2015 Annual Research Report
  • [Book] Advances in Medicine and Biology2014

    • Author(s)
      Wataru Aoi, Yoshinori Marunaka
    • Total Pages
      13
    • Publisher
      Nova Publishers, Inc.
    • Related Report
      2013 Annual Research Report

URL: 

Published: 2013-05-21   Modified: 2019-07-29  

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