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Exercise intervention to prevent sarcopenia: molecular mechanisms involved in concurrent exercise

Research Project

Project/Area Number 25282200
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Sports science
Research InstitutionRitsumeikan University

Principal Investigator

Fujita Satoshi  立命館大学, スポーツ健康科学部, 教授 (80451863)

Co-Investigator(Kenkyū-buntansha) HAMAOKA Takafumi  東京医科大学, 医学部, 教授 (70266518)
IEMITSU Motoyuki  立命館大学, スポーツ健康科学部, 教授 (90375460)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Keywordsレジスタンス運動 / 有酸素性運動 / コンカレント運動 / 骨格筋 / たんぱく質代謝 / 高齢者 / 筋肥大 / サルコペニア / 有酸素運動 / mTOR
Outline of Final Research Achievements

Concurrent training, a combination of endurance (EE) and resistance exercise (RE) performed in succession, may compromise the muscle hypertrophic adaptations induced by RE alone. We used an animal model to investigate whether EE before or after RE affects the molecular signaling associated with muscle protein synthesis. Our results suggested that the last bout of exercise dictates the molecular responses and that mTORC1 signaling induced by any prior bout of RE may be downregulated by a subsequent bout of EE. On the contrary, young men performed the concurrent training three times per week for 12 weeks, the results were conflicting. We compared the exercise order of RE and EE in same session on the same individuals by using unilateral leg exercise for RE. We found no significant difference in the magnitude of increase in strength or muscle CSA after the training period. Further studies are necessary to investigate further on the effect of concurrent training in longer intervention.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (16 results)

All 2015 2014 2013 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (7 results) (of which Int'l Joint Research: 1 results) Book (1 results)

  • [Journal Article] Resistance exercise increases active MMP and β1-integrin protein expression in skeletal muscle.2014

    • Author(s)
      Ogasawara R, Nakazato K, Sato K, Boppart MD, Fujita S.
    • Journal Title

      Physiol Rep.

      Volume: 2(11) Issue: 11 Pages: e12212-e12212

    • DOI

      10.14814/phy2.12212

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Serum sexsteroids and steroidogenesis-related enzymes in skeletal muscle during experimentalweight gain in men2014

    • Author(s)
      Sato K, Samocha-Bonet D, Handelsman DJ, Fujita S, Wittert GA, Heilbronn LK
    • Journal Title

      Diabetes & Metabolism

      Volume: (in press) Issue: 6 Pages: 439-444

    • DOI

      10.1016/j.diabet.2014.03.006

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduction of arterial stiffness by exercise training is associated with increasing plasma apelin level in middle-aged and older adults.2014

    • Author(s)
      Fujie S, Sato K, Miyamoto-Mikami E, Hasegawa N, Fujita S, Sanada K, Hamaoka T, Iemitsu M.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 4 Pages: e93545-e93545

    • DOI

      10.1371/journal.pone.0093545

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The order of concurrent endurance and resistance exercise modifies mTOR signaling and protein synthesis in rat skeletal muscle.2014

    • Author(s)
      Ogasawara, R., Sato, K., Matsutani, K., Nakazato, K., Fujita, S.
    • Journal Title

      Am J Physiol Endocrinol Metab

      Volume: 印刷中

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Resistance training restores muscle sex steroid hormone steroidogenesis in older men.2014

    • Author(s)
      Sato K, Iemitsu M, Matsutani K, Kurihara T, Hamaoka T, Fujita S.
    • Journal Title

      FASEB

      Volume: 28(4) Issue: 4 Pages: 1891-7

    • DOI

      10.1096/fj.13-245480

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Acute administration of diosgenin or dioscorea improves hyperglycemia with increases muscular steroidogenesis in STZ-induced type 1 diabetic rats2014

    • Author(s)
      Sato K, Fujita S, Iemitsu M
    • Journal Title

      J Steroid Biochem and Molecu Biol

      Volume: 143 Pages: 152-159

    • DOI

      10.1016/j.jsbmb.2014.02.020

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ursolic acid stimulates mTORC1 signaling after resistance exercise in rat skeletal muscle2013

    • Author(s)
      Ogasawara R, Sato K, Higashida K, Nakazato K, Fujita S.
    • Journal Title

      Am J Physiol Endocrinol Metab.

      Volume: 305(6) Issue: 6 Pages: 760-765

    • DOI

      10.1152/ajpendo.00302.2013

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] mTOR signaling response to resistance exercise is altered by chronic resistance training and detraining in skeletal muscle2013

    • Author(s)
      Ogasawara R, Kobayashi K, Tsutaki A., Lee K., Abe T., Fujita S., Nakazato K, Ishii N.
    • Journal Title

      J Appl Physiol

      Volume: 114 Issue: 7 Pages: 934-940

    • DOI

      10.1152/japplphysiol.01161.2012

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Effect Of The Order Of Concurrent Resistance And Endurance Exercise On Traininginduced Muscle Hypertrophy2015

    • Author(s)
      Tokushi Umeno, Kohei Sase, Naomi Yoshii, Syohei Sasaki, Yuhei Makanae, Riki Ogasawara, Toshiyuki Homma, Takafumi Hamaoka, Satoshi Fujita
    • Organizer
      20th annual Congress of the European College of Sport Science62nd American College of Sports Medicine
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2015-05-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Resistance Exercise, But Not Endurance Exercise, Increases Vitamin D Receptor And CYP27B1 Expression In Rat Skeletal Muscle.2014

    • Author(s)
      Yuhei Makanae,Riki Ogasawara,Kenji Matsutani,Koichi Nakazato,Naruhiro Shiozawa,Satoshi Fujita.
    • Organizer
      ACSM Conference on Integrative Physiology of Exercise.
    • Place of Presentation
      Miami, (アメリカ)
    • Year and Date
      2014-09-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effect of Divergent Muscle Contraction Mode on Erk-mTOR Pathway.2014

    • Author(s)
      Satoru Ato,Yuhei Makanae,Kenji Matsutani,Riki Ogasawara,Koichi Nakazato,Naruhiro Shiozawa,Satoshi Fujita.
    • Organizer
      ACSM Conference on Integrative Physiology of Exercise.
    • Place of Presentation
      Miami, (アメリカ)
    • Year and Date
      2014-09-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Herbal Medicine Kamishimotsuto Stimulates mTORC1 Signaling after Resistance Exercise in Rat Skeletal Muscle.2014

    • Author(s)
      Kohei Kido,Satoru Ato,Yuhei Makanae,Tadahiro Hayashi,Satoshi Fujita.
    • Organizer
      ACSM Conference on Integrative Physiology of Exercise.
    • Place of Presentation
      Miami, (アメリカ)
    • Year and Date
      2014-09-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effect of oligomerized polyphenol supplementation on lipid metabolism during exercise in healthy men.

    • Author(s)
      Miyake, T., Sato, K., Matsutani, K., Iemitsu, M., Nishizawa, T., Miura, T., Isaka, T., Fujita, S.
    • Organizer
      Annual Meeting of Experimental Biology
    • Place of Presentation
      Boston, U.S.A
    • Related Report
      2013 Annual Research Report
  • [Presentation] The cross-sectional study of the relationships among household physical activity, locomotive physical activity and metabolic syndrome risks factors.

    • Author(s)
      K. Okumatsu, M. Aoki, S. Watanabe, M. Iemitsu, K. Sato, T. Kurihara, M. Otsuka, M. Fujioka, S. Fujita, T. Hamaoka, K. Sanada.
    • Organizer
      18th Annual congress of the European College of Sport Science
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effect of a Combined Supervised and Unsupervised Resistance Training Program on Muscle Mass and Function in Older Individuals.

    • Author(s)
      Fujita, S., Matsutani, M., Ozawa, M., Yamaura, K., Nagazumi, J., Ebi, K., Otomo, S.
    • Organizer
      Annual Conference of International Conference on Education and Social Sciences
    • Place of Presentation
      Singapore
    • Related Report
      2013 Annual Research Report
  • [Book] 体育・スポーツ系指導者・学生のためのスポーツ栄養学2014

    • Author(s)
      田口 素子、樋口  満(編)海老根直之、藤田  聡、木村 典代、小清水孝子、松本  恵、松本 範子、長島未央子、内藤 祐子、呉  泰雄、麻見 直美、杉浦 克己、髙田 和子、横田由香里
    • Total Pages
      216
    • Publisher
      市村出版
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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