Exercise intervention to prevent sarcopenia: molecular mechanisms involved in concurrent exercise
| Project/Area Number |
25282200
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
Fujita Satoshi 立命館大学, スポーツ健康科学部, 教授 (80451863)
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| Co-Investigator(Kenkyū-buntansha) |
HAMAOKA Takafumi 東京医科大学, 医学部, 教授 (70266518)
IEMITSU Motoyuki 立命館大学, スポーツ健康科学部, 教授 (90375460)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | レジスタンス運動 / 有酸素性運動 / コンカレント運動 / 骨格筋 / たんぱく質代謝 / 高齢者 / 筋肥大 / サルコペニア / 有酸素運動 / mTOR |
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| Outline of Final Research Achievements |
Concurrent training, a combination of endurance (EE) and resistance exercise (RE) performed in succession, may compromise the muscle hypertrophic adaptations induced by RE alone. We used an animal model to investigate whether EE before or after RE affects the molecular signaling associated with muscle protein synthesis. Our results suggested that the last bout of exercise dictates the molecular responses and that mTORC1 signaling induced by any prior bout of RE may be downregulated by a subsequent bout of EE. On the contrary, young men performed the concurrent training three times per week for 12 weeks, the results were conflicting. We compared the exercise order of RE and EE in same session on the same individuals by using unilateral leg exercise for RE. We found no significant difference in the magnitude of increase in strength or muscle CSA after the training period. Further studies are necessary to investigate further on the effect of concurrent training in longer intervention.
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Report
(4 results)
Research Products
(16 results)
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[Presentation] Effect of oligomerized polyphenol supplementation on lipid metabolism during exercise in healthy men.
Author(s)
Miyake, T., Sato, K., Matsutani, K., Iemitsu, M., Nishizawa, T., Miura, T., Isaka, T., Fujita, S.
Organizer
Annual Meeting of Experimental Biology
Place of Presentation
Boston, U.S.A
Related Report
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[Presentation] The cross-sectional study of the relationships among household physical activity, locomotive physical activity and metabolic syndrome risks factors.
Author(s)
K. Okumatsu, M. Aoki, S. Watanabe, M. Iemitsu, K. Sato, T. Kurihara, M. Otsuka, M. Fujioka, S. Fujita, T. Hamaoka, K. Sanada.
Organizer
18th Annual congress of the European College of Sport Science
Place of Presentation
Barcelona, Spain
Related Report
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[Presentation] Effect of a Combined Supervised and Unsupervised Resistance Training Program on Muscle Mass and Function in Older Individuals.
Author(s)
Fujita, S., Matsutani, M., Ozawa, M., Yamaura, K., Nagazumi, J., Ebi, K., Otomo, S.
Organizer
Annual Conference of International Conference on Education and Social Sciences
Place of Presentation
Singapore
Related Report
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