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metabolic regulatory system in terms of inter- or extra- cellular lipid recruitment in working muscle

Research Project

Project/Area Number 25282201
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Sports science
Research InstitutionRitsumeikan University

Principal Investigator

Taguchi Sadayoshi  立命館大学, 総合科学技術研究機構, 客員研究員 (90086819)

Co-Investigator(Kenkyū-buntansha) YAMAUCHI Junichiro  首都大学東京, 人間健康科学研究科, 准教授 (70552321)
HASHIMOTO Takeshi  立命館大学, スポーツ健康科学部, 准教授 (70511608)
MORITA Noriteru  北海道教育大学, 教育学部, 准教授 (10382540)
KURIHARA Toshiyuki  立命館大学, スポーツ健康科学部, 助教 (10454076)
OTSUKA Mitsuo  立命館大学, スポーツ健康科学部, 助教 (20611312)
MATSUO Kaori  東北大学, 大学院医学系研究科, 助教 (60513570)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Keywords脂質代謝 / 体組成 / 骨格筋 / 局所運動 / 筋内外脂肪 / 核磁気共鳴画像法 / 生活習慣 / 皮下脂肪 / 筋内脂肪 / 筋量 / 二足歩行 / 環境汚染 / 肥満 / エネルギー代謝 / 脂肪 / グルコース / 低強度運動 / MR
Outline of Final Research Achievements

The aim of this study was to elucidate metabolic regulatory system in terms of “inter- or extra- cellular lipid recruitment in working muscle”. In particular, based on the data obtained in non-invasive MRI measurements and molecular biologic study, we tried to investigate the energy metabolism during muscle contraction.
As a clue to advance our understanding of metabolic function of the skeletal muscle, which is significantly related to obesity and disorder of fat metabolism in today, we have focused on the difference of energy metabolism in upper and lower limbs, especially in the aspect of “evolution”(e.g., The morphological characters of the upper and lower limbs in humans could adapt differently over years after becoming bipedal), and fat metabolism in upper and lower limbs. As a result, we could obtain new findings in terms of “inter- or extra- cellular lipid recruitment in working muscle”.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (15 results)

All 2015 2014 2013 Other

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (9 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Specific characterization of regional storage fat in upper and lower limbs of young healthy adults2015

    • Author(s)
      Junichiro Yamauchi, Toshiyuki Kurihara, Maki Yoshikawa, Sadayoshi Taguchi, Takeshi Hashimoto
    • Journal Title

      Springer Plus

      Volume: 4 Issue: 1 Pages: 402-402

    • DOI

      10.1186/s40064-015-1181-6

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Toe flexor strength and foot arch height in children.2015

    • Author(s)
      Morita N, Yamauchi J, Kurihara T, Fukuoka R, Otsuka M, Okuda T, Ishizawa N, Nakajima T, Nakamichi R, Matsuno S, Kamiie S, Shide N, Kambayashi I, Shinkaiya H.
    • Journal Title

      Med Sci Sports Exerc.

      Volume: 47 Issue: 2 Pages: 350-356

    • DOI

      10.1249/mss.0000000000000402

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Toe flexor strength and lower-limb physical performance in adolescent.2015

    • Author(s)
      Otsuka M, Yamauchi J, Kurihara T, Morita N and Isaka T.
    • Journal Title

      Gazzetta Medica Italiana Archivio per le Scienze Mediche.

      Volume: 印刷中

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Maximum toe flexor muscle strength and quantitative analysis of human plantar intrinsic and extrinsic muscles by a magnetic resonance imaging technique.2014

    • Author(s)
      Kurihara T, Yamauchi J, Otsuka M, Tottori N, Hashimoto T, Isaka T.
    • Journal Title

      J Foot Ankle Res

      Volume: 7 Issue: 1 Pages: 26-26

    • DOI

      10.1186/1757-1146-7-26

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Overexpression of leptin reduces the ratio of glycolytic to oxidative enzymatic activities without changing muscle fiber types in mouse skeletal muscle.2014

    • Author(s)
      Masuda S, Tanaka T, Masuzaki H, Nakao K, and Taguchi S.
    • Journal Title

      Biol.Pharm.Bull.

      Volume: 37 Pages: 169-173

    • NAID

      130003382099

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Modest hypoxia significantly reduces triglyceride content and lipid droplet size in 3T3-L1 adipocytes.2013

    • Author(s)
      Hashimoto T, Yokokawa T, Endo Y, Iwanaka N, Higashida K, and Taguchi S.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 440 Issue: 1 Pages: 43-49

    • DOI

      10.1016/j.bbrc.2013.09.034

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 高所4000m酸素環境下における活動筋の発汗特性2015

    • Author(s)
      小池英晃, 森田憲輝, 小山桂史, 橋本健志, 田口貞善, 山内潤一郎
    • Organizer
      第70回日本体力医学会大会
    • Place of Presentation
      和歌山県民文化会館、和歌山県和歌山市
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 歩動作時の上肢と下肢: ヒトが4足で歩くと?2015

    • Author(s)
      山内潤一郎, 小池英晃, 清水麻由子, 湯浅健人, 小山桂史, 橋本健志, 田口貞善
    • Organizer
      第70回日本体力医学会大会
    • Place of Presentation
      和歌山県民文化会館、和歌山県和歌山市
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 高所4000m酸素環境曝露における低強度運動時のエネルギー利用と血中乳酸濃度2015

    • Author(s)
      小池英晃, 森田憲輝, 小山桂史, 橋本健志, 田口貞善, 山内潤一郎
    • Organizer
      第164回日本体力医学会関東地方会
    • Place of Presentation
      桐蔭横浜大学、神奈川県横浜市
    • Year and Date
      2015-07-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Ambient Particular Matter (pm) Exposure Deteriorates Pulmonary Function in Early Childhood in Shanghai, China2015

    • Author(s)
      Taguchi S, Otsuka M, Suzuki K, Yamasaki S, Kitagawa K, Yin X-J, Ji L, Zhou Y-R, Liu X, and Hashimoto T
    • Organizer
      62th American College of Sport Medicine
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2015-05-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The relationship between subcutaneous fat and intramuscular lipid in human limb.2014

    • Author(s)
      Yoshikawa M, Kurihara T, Taguchi S, Yamauchi J, and Hashimoto T.
    • Organizer
      19th European College of Sport Science
    • Place of Presentation
      Amsterdam(Netherlands)
    • Year and Date
      2014-07-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] Body composition of human limbs by using BIA and MRI.

    • Author(s)
      Yoshikawa M, Kurihara T, Taguchi S, Yamauchi J, Hashimoto T.
    • Organizer
      18th European College of Sport Science,
    • Place of Presentation
      Barcelona, Spain.
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヒト上腕部における皮下脂肪と筋内脂肪の関係

    • Author(s)
      吉川 万紀、栗原 俊之、田口 貞善、山内 潤一郎、橋本 健志
    • Organizer
      日本体力医学会
    • Place of Presentation
      日本教育会館(東京都)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Aging, not inactvity, alters lactate metabolic properties to facilitate lactate oxidation in fast-type skeletal muscle.

    • Author(s)
      Sadayoshi, Taguchi, Shinya Masuda, Tatsuro Egawa, Tatsuya Hayashi
    • Organizer
      Med.Sci.Sports Exerc
    • Place of Presentation
      Indianapolis, U.S.A.
    • Related Report
      2013 Annual Research Report
  • [Presentation] Relation between waist circumference and body mass index in Chinese children and adlescents.

    • Author(s)
      Xiao Jian Yin, Chen Ye Ji, Liu Ji, Qiang Guo, Shi Chang Li, Sadayoshi Taguchi, Toyoho Tanaka.
    • Organizer
      Med.Sci.Sports Exerc.
    • Place of Presentation
      Indianapolis, U.S.A.
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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