Elucidation of the mechanisms of skeletal muscle hypertrophy by intracellular calcium concentration.
| Project/Area Number |
25282202
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
TAKEDA SHIN'ICHI 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 遺伝子疾患治療研究部, 部長 (90171644)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI YUUKO 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 遺伝子疾患 治療研究部, 室長 (00342931)
AOKI YOSHITSUGU 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 遺伝子疾患治療研究部, 室長 (80534172)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Keywords | 筋肥大 / 筋萎縮 / カルシウム / nNOS / NO / ATP / P2Y / IP3R |
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| Outline of Final Research Achievements |
Skeletal muscle atrophy occurs in ageing, and several pathological conditions including cancer, renal failure, AIDS, sepsis and diabetes. We aim to elucidate the molecular mechanisms of muscle hypertrophy by focusing on the intracellular calcium concentration, which will lead to the development of novel therapy for muscle atrophy. As a results, we elucidated that extracellular ATP promoted muscle hypertrophy by increasing intracellular calcium concentration and subsequent activation of mTOR and MAPK.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] G-CSF supports long-term muscle regeneration in mouse models of muscular dystrophy2015
Author(s)
Hayashiji N, Yuasa S, Miyagoe-Suzuki Y, Hara M, Ito N, Hashimoto H, Kusumoto D, Seki T, Tohyama S, Kodaira M, Kunitomi A, Kashimura S, Takei M, Saito Y, Okata S, Egashira T, Endo J, Sasaoka T, Takeda S, Fukuda K
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Journal Title
Nature Communications
Volume: 6
Issue: 1
Pages: 6745-6745
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A Muscle-liver-fat signaling axis is essential for central control of adaptive adipose remodeling2015
Author(s)
Shimizu N, Maruyama T, Yoshikawa N, Matsumiya R, Ma Y, Ito N, Tasaka Y, Kuribara-Souta A, Miyata K, Oike Y, Berger S, Schutz G, Takeda S & Tanaka H
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Journal Title
Nat Commun
Volume: -
Issue: 1
Pages: 6693-6693
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Calcitonin Receptor Signaling Inhibits Muscle Stem Cells from Escaping the Quiescent State and the Niche2015
Author(s)
Yamaguchi M, Watanabe Y, Ohtani T, Uezumi A, Mikami N, Nakamura M, Sato T, Ikawa M, Hoshino M, Tsuchida K, Miyagoe-Suzuki Y, Tsujikawa K, Takeda S, Yamamoto H, Fukada S
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Journal Title
Cell Rep
Volume: 13(2)
Issue: 2
Pages: 302-314
DOI
NAID
Related Report
Peer Reviewed / Open Access
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