Anti-fatigue study based on objective evaluation methods for fatigability and recovery from fatigue in adolescence

• Project/Area Number: 25282211
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Mizuno Kei 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, 上級研究員 (60464616)
• Co-Investigator(Kenkyū-buntansha): JOUDOI Takako 熊本大学, 医学部附属病院, 助教 (90363522)
• Co-Investigator(Renkei-kenkyūsha): KAWATANI Junko 熊本大学, 医学部附属病院, 診療助手 (30423669)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000); Fiscal Year 2015: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2013: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
• Keywords: 疲労 / 思春期 / 自律神経 / 発達 / 睡眠 / 認知機能 / パフォーマンス / 小児慢性疲労症候群 / 慢性疲労症候群 / 小児 / 治療

Outline of Final Research Achievements

The aim of the present study was the development of objective evaluation methods for fatigability and recovery from fatigue based on the physiological mechanisms of fatigue of elementary and junior high school students and patients childhood chronic fatigue syndrome (CCFS). Using attention control task and autonomic nerve function test, etc., objective fatigue-evaluation methods was developed. In the CCFS patients, this method was useful for identifying not only fatigability and recovery from fatigue but also treatment effect. A preliminary epidemiological survey of fatigue revealed the trend of increase in fatigued students, suggesting that it is necessary of the progress of study to overcoming fatigue in children and adolescents.

Research Products

• [Journal Article] Less efficient and costly processes of frontal cortex in childhood chronic fatigue syndrome (2015)
  • Author(s): Mizuno K, Tanaka M, Tanabe H. C, Joudoi T, Kawatani J, Shigihara Y, Tomoda A, Miike T, Imai-Matsumura K, Sadato N, Watanabe Y
  • Journal Title: Neuroimage: Clinical Volume: 9 Pages: 355-368
  • DOI: 10.1016/j.nicl.2015.09.001
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Regional brain disorders of serotonin neurotransmission are associated with functional dyspepsia. (2015)
  • Author(s): Tominaga, K., Tsumoto, C., Ataka, S., Mizuno, K., Takahashi, K., Yamagami, H., Tanigawa, T., Kawabe, J., Watanabe, T., Fujiwara, Y., Shiomi, S., Watanabe, Y., and Arakawa, T.
  • Journal Title: Life Sci. Volume: 137 Pages: 150-157
  • DOI: 10.1016/j.lfs.2015.07.023
  • Peer Reviewed / Open Access
• [Journal Article] Fatigue correlates with the decrease in parasympathetic sinus modulation induced by a cognitive challenge (2014)
  • Author(s): Mizuno, K., Tajima, K., Kuratsune, H., Watanabe, Y.
  • Journal Title: Behavioral and Brain Functions Volume: 10 Issue: 1 Pages: 1-8
  • DOI: 10.1186/1744-9081-10-25
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 小児・思春期の疲労・慢性疲労による意欲低下 (2014)
  • Author(s): 水野 敬，友田明美，渡辺恭良
  • Journal Title: 日本疲労学会誌 Volume: 10 Pages: 101-103
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Neurocognitive impairment in childhood chronic fatigue syndrome (2013)
  • Author(s): Mizuno Kei
  • Journal Title: Frontiers in Physiology Volume: 4 Pages: 87-87
  • DOI: 10.3389/fphys.2013.00087
  • Peer Reviewed
• [Journal Article] Divided attention of adolescents related to lifestyles and academic and family conditions (2013)
  • Author(s): Mizuno Kei, Tanaka Masaaki, Fukuda Sanae, Imai-Matsumura Kyoko, Watanabe Yasuyoshi
  • Journal Title: Brain & Development Volume: 35 Issue: 5 Pages: 435-440
  • DOI: 10.1016/j.braindev.2012.07.007
  • Peer Reviewed
• [Presentation] 抗疲労に資する環境空間開発 (2016)
  • Author(s): 水野敬，佐々木章宏，田島華奈子，渡辺恭介，堀洋，梶本修身，渡辺恭良
  • Organizer: 第127回日本森林学会大会
  • Invited
• [Presentation] Autonomic nerve alteration caused by fatigue in children and adolescents (2015)
  • Author(s): Mizuno K, Joudoi T.
  • Organizer: The 120th Annual Meeting of The Japanese Association of Anatomists & the 92nd Annual Meeting of The Physiological Society of Japan
  • Place of Presentation: Kobe Convention Center (Kobe)
  • Year and Date: 2015-03-23
  • Invited
• [Presentation] 疲労による脳の構造的変化 (2015)
  • Author(s): 水野敬，定藤規弘，渡辺恭良
  • Organizer: 第11回日本疲労学会総会・学術集会
  • Invited
• [Presentation] 小児慢性疲労症候群の易疲労性・疲労回復性と治療効果 (2015)
  • Author(s): 水野敬，上土井貴子，高野美雪，川谷淳子，田島華奈子，梶本修身，渡辺恭良
  • Organizer: 第11回日本疲労学会総会・学術集会
• [Presentation] Attentional and motivational deficits in patients with childhood chronic fatigue syndrome. (2014)
  • Author(s): Mizuno K, , Tajima K, Sasaki AT, Kawatani J, Joudoi T, Yoneda T, Tomoda A & Watanabe Y
  • Organizer: 11th IACFS/ME Biennial International Research and Clinical Conference
  • Place of Presentation: Parc 55 Wyndham Union Square Hotel (San Francisco), USA
• [Presentation] Low striatal activity during reward perception caused by adolescent chronic fatigue (2013)
  • Author(s): Mizuno K, Tajima K, Kawatani J, Joudoi T, Yoneda T, Tomoda A, & Watanabe Y
  • Organizer: The 36th Annual Meeting of the Japan Neuroscience Society (Neuro 2013)
  • Place of Presentation: Kyoto International Conference Center (Kyoto)
• [Presentation] 小児の疲労・慢性疲労による意欲低下の神経基盤 (2013)
  • Author(s): 水野 敬
  • Organizer: 第9回日本疲労学会総会・学術集会
  • Place of Presentation: 秋田県総合保健センター（秋田）