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Anti-fatigue study based on objective evaluation methods for fatigability and recovery from fatigue in adolescence

Research Project

Project/Area Number 25282211
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Applied health science
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Mizuno Kei  国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, 上級研究員 (60464616)

Co-Investigator(Kenkyū-buntansha) JOUDOI Takako  熊本大学, 医学部附属病院, 助教 (90363522)
Co-Investigator(Renkei-kenkyūsha) KAWATANI Junko  熊本大学, 医学部附属病院, 診療助手 (30423669)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2015: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywords疲労 / 思春期 / 自律神経 / 発達 / 睡眠 / 認知機能 / パフォーマンス / 小児慢性疲労症候群 / 慢性疲労症候群 / 小児 / 治療
Outline of Final Research Achievements

The aim of the present study was the development of objective evaluation methods for fatigability and recovery from fatigue based on the physiological mechanisms of fatigue of elementary and junior high school students and patients childhood chronic fatigue syndrome (CCFS). Using attention control task and autonomic nerve function test, etc., objective fatigue-evaluation methods was developed. In the CCFS patients, this method was useful for identifying not only fatigability and recovery from fatigue but also treatment effect. A preliminary epidemiological survey of fatigue revealed the trend of increase in fatigued students, suggesting that it is necessary of the progress of study to overcoming fatigue in children and adolescents.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (13 results)

All 2016 2015 2014 2013

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (7 results) (of which Invited: 3 results)

  • [Journal Article] Less efficient and costly processes of frontal cortex in childhood chronic fatigue syndrome2015

    • Author(s)
      Mizuno K, Tanaka M, Tanabe H. C, Joudoi T, Kawatani J, Shigihara Y, Tomoda A, Miike T, Imai-Matsumura K, Sadato N, Watanabe Y
    • Journal Title

      Neuroimage: Clinical

      Volume: 9 Pages: 355-368

    • DOI

      10.1016/j.nicl.2015.09.001

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Regional brain disorders of serotonin neurotransmission are associated with functional dyspepsia.2015

    • Author(s)
      Tominaga, K., Tsumoto, C., Ataka, S., Mizuno, K., Takahashi, K., Yamagami, H., Tanigawa, T., Kawabe, J., Watanabe, T., Fujiwara, Y., Shiomi, S., Watanabe, Y., and Arakawa, T.
    • Journal Title

      Life Sci.

      Volume: 137 Pages: 150-157

    • DOI

      10.1016/j.lfs.2015.07.023

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fatigue correlates with the decrease in parasympathetic sinus modulation induced by a cognitive challenge2014

    • Author(s)
      Mizuno, K., Tajima, K., Kuratsune, H., Watanabe, Y.
    • Journal Title

      Behavioral and Brain Functions

      Volume: 10 Issue: 1 Pages: 1-8

    • DOI

      10.1186/1744-9081-10-25

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 小児・思春期の疲労・慢性疲労による意欲低下2014

    • Author(s)
      水野 敬,友田明美,渡辺恭良
    • Journal Title

      日本疲労学会誌

      Volume: 10 Pages: 101-103

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Neurocognitive impairment in childhood chronic fatigue syndrome2013

    • Author(s)
      Mizuno Kei
    • Journal Title

      Frontiers in Physiology

      Volume: 4 Pages: 87-87

    • DOI

      10.3389/fphys.2013.00087

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Divided attention of adolescents related to lifestyles and academic and family conditions2013

    • Author(s)
      Mizuno Kei, Tanaka Masaaki, Fukuda Sanae, Imai-Matsumura Kyoko, Watanabe Yasuyoshi
    • Journal Title

      Brain & Development

      Volume: 35 Issue: 5 Pages: 435-440

    • DOI

      10.1016/j.braindev.2012.07.007

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 抗疲労に資する環境空間開発2016

    • Author(s)
      水野敬,佐々木章宏,田島華奈子,渡辺恭介,堀洋,梶本修身,渡辺恭良
    • Organizer
      第127回日本森林学会大会
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Autonomic nerve alteration caused by fatigue in children and adolescents2015

    • Author(s)
      Mizuno K, Joudoi T.
    • Organizer
      The 120th Annual Meeting of The Japanese Association of Anatomists & the 92nd Annual Meeting of The Physiological Society of Japan
    • Place of Presentation
      Kobe Convention Center (Kobe)
    • Year and Date
      2015-03-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 疲労による脳の構造的変化2015

    • Author(s)
      水野敬,定藤規弘,渡辺恭良
    • Organizer
      第11回日本疲労学会総会・学術集会
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 小児慢性疲労症候群の易疲労性・疲労回復性と治療効果2015

    • Author(s)
      水野敬,上土井貴子,高野美雪,川谷淳子,田島華奈子,梶本修身,渡辺恭良
    • Organizer
      第11回日本疲労学会総会・学術集会
    • Related Report
      2015 Annual Research Report
  • [Presentation] Attentional and motivational deficits in patients with childhood chronic fatigue syndrome.2014

    • Author(s)
      Mizuno K, , Tajima K, Sasaki AT, Kawatani J, Joudoi T, Yoneda T, Tomoda A & Watanabe Y
    • Organizer
      11th IACFS/ME Biennial International Research and Clinical Conference
    • Place of Presentation
      Parc 55 Wyndham Union Square Hotel (San Francisco), USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Low striatal activity during reward perception caused by adolescent chronic fatigue2013

    • Author(s)
      Mizuno K, Tajima K, Kawatani J, Joudoi T, Yoneda T, Tomoda A, & Watanabe Y
    • Organizer
      The 36th Annual Meeting of the Japan Neuroscience Society (Neuro 2013)
    • Place of Presentation
      Kyoto International Conference Center (Kyoto)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 小児の疲労・慢性疲労による意欲低下の神経基盤2013

    • Author(s)
      水野 敬
    • Organizer
      第9回日本疲労学会総会・学術集会
    • Place of Presentation
      秋田県総合保健センター(秋田)
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2024-12-25  

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