Development of overeating-induced obese mouse assuming human life style-related diseases and investigation of pathophysiological factors associated with NASH

• Project/Area Number: 25282212
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: University of Tsukuba
• Principal Investigator: Mizogami Yuji 筑波大学, 医学医療系, 准教授 (70268556)
• Co-Investigator(Kenkyū-buntansha): YANAGAWA Toru 筑波大学, 医学医療系, 准教授 (10312852) ; UTSUNOMIYA Hirotoshi 和歌山県立医科大学, 共同利用施設, 准教授 (60264876) ; ISOBE Tomonori 筑波大学, 医学医療系, 准教授 (70383643) ; WARABI Eiji 筑波大学, 医学医療系, 講師 (70396612) ; SHODA Junichi 筑波大学, 医学医療系, 教授 (90241827)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2013: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
• Keywords: 肥満 / 非アルコール性脂肪性肝炎 / 遺伝子改変マウス / リポ多糖 / Kupffer細胞 / 生活習慣病 / 過食肥満マウス / 脂肪性肝炎 / 腸内細菌叢 / 自然免疫 / NASH

Outline of Final Research Achievements

Nonalcoholic steatohepatitis (NASH) is a chronic liver disease that develops from simple steatosis to liver cirrhosis and hepatocellular carcinoma. Effective prevention and treatment methods are strongly desired. We generated double knockout (DKO) mice without Sqstm1 and Nrf2 genes. In DKO mice, a number of biological molecules from the intestine and adipose tissue in addition to liver may play central roles in the onset of NASH. The serum LPS levels were significantly higher in DKO mice than that in WT mice. Furthermore, the intestinal permeability and the gram-negative bacteria levels and endotoxin in feces were all increased significantly in DKO mice. DKO mice had a significant decrease in Kupffer cells (KCs)’ phagocytic function. The overload of serum LPS induced by the modification of intestine microbiota, the increase of intestinal permeability, and the impaired clearance of LPS by KCs dysfunction were considered to be important for the progression of NASH in DKO mice.

Research Products

• [Journal Article] Verification of WFA-Sialylated MUC1 as a Sensitive Biliary Biomarker for Human Biliary Tract Cancer. (2016)
  • Author(s): Yamaguchi T, Yokoyama Y, Ebata T, Matsuda A, Kuno A, Ikehara Y,Shoda J, Narimatsu H, Nagino M.
  • Journal Title: Ann Surg Oncol. Volume: 23(2) Issue: 2 Pages: 671-677
  • DOI: 10.1245/s10434-015-4878-4
  • Peer Reviewed / Open Access
• [Journal Article] Cytoprotective Role of Nrf2 in Electrical Pulse Stimulated C2C12 Myotube. (2015)
  • Author(s): Horie M, Warabi E, Komine S, Oh S, Shoda J.
  • Journal Title: PLoS One Volume: 10 Issue: 12 Pages: 12-12
  • DOI: 10.1371/journal.pone.0144835
  • NAID: 120007127849
  • Peer Reviewed / Open Access
• [Journal Article] Viwatthanasittiphong C, Srivatanakul P, Miwa M, Shoda J, Narimatsu H. Lectin Microarray-Based Sero-Biomarker Verification Targeting Aberrant O-Linked Glycosylation on Mucin 1. (2015)
  • Author(s): Matsuda A, Kuno A, Nakagawa T, Ikehara Y, Irimura T, Yamamoto M, Nakanuma Y, Miyoshi E, Nakamori S, Nakanishi H.
  • Journal Title: Anal Chem. Volume: 87(14) Issue: 14 Pages: 7274-7281
  • DOI: 10.1021/acs.analchem.5b01329
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] FibroScan502の肝脂肪量測定による非アルコール性脂肪性肝疾患の非侵襲的診断法の有用性について. (2015)
  • Author(s): 志田隆史，磯辺智範，呉 世昶，上牧 隆，岡本嘉一，安藤浩樹，正田純一
  • Journal Title: 日本超音波技師学会雑誌 Volume: 40 Pages: 167-73
  • Peer Reviewed / Open Access
• [Journal Article] Qing Dai attenuates nonsteroidal anti-inflammatory drug-induced mitochondrial reactive oxygen species in gastrointestinal epithelial cells (2015)
  • Author(s): Saito R, Tamura M, Matsui H, Nagano Y, Suzuki H, Kaneko T, Mizokami Y, Hyodo I
  • Journal Title: J Clin Biochem Nutr Volume: 56 Pages: 8-14
  • NAID: 130004704975
  • Peer Reviewed / Open Access
• [Journal Article] Moderate to vigorous physical activity is an important factor for managing non-alcoholic fatty liver disease: a retrospective study. (2015)
  • Author(s): Oh S, Tanaka K, Chiaki K, Tsujimoto T, So R, Shida T, Shoda J
  • Journal Title: Hepatology Volume: 61 Pages: 1205-1215
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Overexpression and Gene Amplification of HER1, HER2 and HER3 in Biliary Tract Carcinomas and the Possibility for Therapy with a HER2-Targeting Antibody Pertuzumab. (2015)
  • Author(s): Kawamoto T, Thomas M, Yamashita-Kashima Y, Shu S, Ishikura N, Ariizumi S, Yamamoto M, Kurosaki K, Shoda J.
  • Journal Title: J Gastroenterrol Volume: 50 Pages: 467-479
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Therapeutic effect of hybrid training of voluntary and electrical muscle contractions on middle-aged obese women with NAFLD: a pilot study. (2015)
  • Author(s): Oh S, Shida T, Ikeda A, Maruyama T, Eguchi K, Isobe T, Okamoto Y, Arai E, Shiba N, Shoda J.
  • Journal Title: Ther Clin Risk Manag Volume: 11 Pages: 371-80
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Expression of insulin-like growth factor receptor (IGFR) as a useful biomarker for predicting prognosis in biliary tract cancer patients. (2015)
  • Author(s): Suzuki H, Roa JC, Kawamoto T, Ishige K, Shoda J, Wistuba II, Li D, Thomas MB.
  • Journal Title: Mol & Clin Oncol Volume: 3 Pages: 464-470
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Moderate to vigorous physical activity volume is an important factor for managing non-alcoholic fatty liver disease : A retrospec tive study (2014)
  • Author(s): Oh S, Shida T, Tanaka K, Y amagishi K, So R, Tsujimoto T, Shoda J:
  • Journal Title: Hepatology 2014, Volume: 61(4) Issue: 4 Pages: 1205-1215
  • DOI: 10.1002/hep.27544
  • Peer Reviewed / Open Access
• [Journal Article] Risk factors for submucosal and lymphovascular invasion in gastric cancer looking indicative for endoscopic submucosal dissection (2014)
  • Author(s): Yamada T, Sugiyama H, Ochi D, Akutsu D, Suzuki H, Narasaka T, Moriwaki T, Endo S, Kaneko T, Satomi K, Ikezawa K, Mizokami Y, Hyodo I
  • Journal Title: Gastric Cancer Volume: 17 Pages: 692-696
  • Peer Reviewed / Open Access
• [Journal Article] A case of cap polyposis remission by betamethasone enema after antibiotics therapy including Helicobacter pylori eradication (2014)
  • Author(s): Suzuki H, Sato M, Akutsu D, Sugiyama H, Sato T, Mizokami Y
  • Journal Title: J Gastrointestin Liver Dis Volume: 23 Pages: 203-206
  • Peer Reviewed / Open Access
• [Journal Article] 茨城県における肝細胞癌疫学調査． (2014)
  • Author(s): 佐野直樹，田村孝史，福永 潔，高野恵輔，山岸良匡，正田純一，相川達也，大河内信弘
  • Journal Title: 肝臓 Volume: 55 Pages: 771-773
  • NAID: 130004897340
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Changes in diffusion tensor imaging (DTI) eigenvalues of skeletal muscle due to hybrid exercise training Magnetic Resonance Imaging. (2014)
  • Author(s): Okamoto Y, Kemp GJ, Isobe T, Sato E, Hirano Y, Shoda J, Minami M.
  • Journal Title: Magnetic Resonance Imaging Volume: 32 Pages: 1297-1300
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Abdominal obesity: causal factor or simply a symptom of obesity-related healyh risk. (2014)
  • Author(s): Oh S, Tanaka K, Noh J, So R, Tsujimoto T, Sasai H, Kim M, Shoda J.
  • Journal Title: Diabetes, Metab Syn & Obesity Volume: 7 Pages: 289-296
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Acceleration training for management of non-alcoholic fatty liver disease: a pilot study. (2014)
  • Author(s): Oh S, Shida T, Onozuka T, Maruyama T, Eguchi K, Isobe T, Okamoto Y, Someya N, Tanaka K, Tozawa A, Arai E, Shoda J.
  • Journal Title: Ther Clin Risk Manag Volume: 10 Pages: 925-936
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Interaction of Muc4 and ErbB2 in a transgenic mouse model of gallbladder carcinoma: potential pathobiological implications. (2014)
  • Author(s): Miyahara N, Ishida H, Ueda T, Kawamoto T, Akimoto Y, Kawakami H, DiGiovanni J, Kiguchi K, Irimura T, Shoda J.
  • Journal Title: Oncol Rep Volume: 32 Pages: 1796-1802
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Regular Exercise Coupled to Diet Regimen Accelerates Reduction of Hepatic Steatosis and Associated Pathological Conditions in Non-Alcoholic Fatty Liver Disease. (2014)
  • Author(s): Oh S, Tanaka K, Tsujimoto T, So R, Eto M, Shoda J.
  • Journal Title: Metabolic Syndrome & Related Disorders Volume: 12 Pages: 290-298
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Interleukin-4 receptor α-based hybrid peptide effectively induces antitumor activity in biliary tract cancer cells. (2014)
  • Author(s): Seto K, Shoda J, Horibe T, Warabi E, Kohno M, Yanagawa T, Bukawa H, Nakanuma Y, Kawakami Y.
  • Journal Title: Int J Hepatol Volume: 10 Pages: 1155-1161
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Peroxidoxin I plays a ptotective role against UVA irradiation through reduction of oxidative stress. (2014)
  • Author(s): Ito T, Kimura S, Seto K, Warabi E, Kawauchi Y, Shoda J, Tabuchi K, Yamagata K, Hasegawa S, Bukawa H, Ishii T, Yanagawa T.
  • Journal Title: J Dermatol Sci Volume: 74 Pages: 9-17
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Expression of N-acetylglucosaminyltransferase V in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder. (2014)
  • Author(s): Onuki K, Sugiyama H, Ishige K, Kawamoto T, Ota T, Ariizumi S, Yamato M, Kadota S, Takeuchi K, Ishikawa A, Onodera M, Onizawa K, Yamamoto M, Miyoshi E, Shoda J.
  • Journal Title: J Gastroenterol Volume: 49 Pages: 702-714
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Expression of N-acetylglucosaminyltransferase V in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder. (2013)
  • Author(s): Kenichiro Onuki
  • Journal Title: J Gastroenterol Volume: 48 Issue: 4 Pages: 702-714
  • DOI: 10.1007/s00535-013-0813-2
  • Peer Reviewed
• [Journal Article] Exercise training decreases elevated serum ferritin and lipid peroxidation marker levels in middle-aged obese men with non-alcoholic fatty liver disease (2013)
  • Author(s): Oh S, Tanaka K, Warabi E, Shoda J
  • Journal Title: Medicine & Science in Sports & Exercise Volume: 45 Pages: 2214-2222
  • Peer Reviewed
• [Journal Article] Deficiency of p62/Sequestosome 1 causes hyperphagia due to leptin resistance in the brain (2013)
  • Author(s): Harada H, Warabi E, Matsuki T, Yanagawa T, Okada K, Uwayama J, Ikeda A, Nakaso K, Kirii K, Noguchi N, Bukawa H, Siow R, Mann G, Shoda J, Ishii T, Sakurai T
  • Journal Title: J Neuroscience Volume: 33 Pages: 14767-14777
  • Peer Reviewed
• [Journal Article] Interleukin-4 receptor α-based hybrid peptide effectively induces antitumor activity in head and neck squamous cell carcinoma (2013)
  • Author(s): Seto K, Shoda J, Horibe T, Warabi E, Ishige K, Yamagata K, Kohno M, Yanagawa T, Bukawa H, Kawakami K
  • Journal Title: Oncology Report Volume: 29 Pages: 2147-53
  • Peer Reviewed
• [Journal Article] Deletion of Nrf2 leads to rapid progression of steatohepatitis in mice fed atherogenic plus high-fat diet (2013)
  • Author(s): Okada K, Warabi E, Sugimoto H, Horie M, Gotoh N, Tokushige K, Hashimoto E, Utsunomiya H, Takahashi H, Ishii T, Yamamoto M, Shoda J
  • Journal Title: J Gastroenterol Volume: 48 Pages: 620-32
  • NAID: 10031177013
  • Peer Reviewed
• [Journal Article] プロバイオテイクスの転写因子賦活化による腸管環境と機能の改善，それによる生活習慣病関連肝疾患の発症予防 (2013)
  • Author(s): 正田純一
  • Journal Title: ヤクルト・バイオサイエンス研究財団 年報 Volume: 21 Pages: 159-169
• [Journal Article] Endoscopic evaluation of low-dose aspirin-induced gastric and duodenal ulcers during prophylaxis with lansoprazole (2013)
  • Author(s): Sakaki N, Ashida K, Mizokami Y, Chiba T, Matsui S, Kanto T, Uemura N, Hiramatsu N, Sugano K
  • Journal Title: Hepatogastroenterology Volume: 60 Pages: 762-767
  • Peer Reviewed
• [Journal Article] Predicting skin toxicity according to EGFR polymorphisms in patients with colorectal cancer receiving antibody against EGFR (2013)
  • Author(s): Saito R, Suzuki H, Yamada T, Endo S, Moriwaki T, Ueno T, Hirose M, Hirai S, Yamato K, Mizokami Y, Hyodo I
  • Journal Title: Anticancer Res Volume: 33 Pages: 4995-4998
  • Peer Reviewed
• [Journal Article] Risk factors for submucosal and lymphovascular invasion in gastric cancer looking indicative for endoscopic submucosal dissection (2013)
  • Author(s): Yamada T, Sugiyama H, Ochi D, Akutsu D, Suzuki H, Narasaka T, Moriwaki T, Endo S, Kaneko T, Satomi K, Ikezawa K, Mizokami Y, Hydo I
  • Journal Title: Gastric Cancer Volume: 10 Issue: 4 Pages: 1-5
  • DOI: 10.1007/s10120-013-0323-1
  • Peer Reviewed
• [Presentation] p62:Nrf2 double knockout mice develop steatohepatitis through the serum endotoxin overload. (2016)
  • Author(s): Kentaro Akiyama, Eiji Warabi, Kosuke Okada, Syunnichi Ariizumi, Masakazu Yamamoto, Junnichi Shoda.
  • Organizer: 25th Conference of the Asian Pacific Association for the Study of the Liver
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2016-02-23
  • Int'l Joint Research
• [Presentation] The effect of female hormones on NAFLD in p62 knockout mice. (2016)
  • Author(s): Miho Ikeuchi, Eiji Warabi, Tsugumi Nagaoka, Syunichi Ariizumi, Masakazu Yamamoto, Junichi Shoda.
  • Organizer: 25th Conference of the Asian Pacific Association for the Study of the Liver
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2016-02-23
  • Int'l Joint Research
• [Presentation] p62: Nrf2遺伝子二重欠損マウスは血清中エンドトキシンが増加し，脂肪性肝炎を発症する. (2015)
  • Author(s): 秋山健太郎、蕨栄治、岡田浩介、正田純一.
  • Organizer: 第88回日本生化学会大会
  • Place of Presentation: 神戸，ポートピアホテル
  • Year and Date: 2015-12-01
• [Presentation] NASH自然発症モデルマウスの腸内環境よりみた疾病病態の解析と発症機序の解明. (2015)
  • Author(s): 秋山健太郎、池内美穂、蕨栄治、正田純一
  • Organizer: 第19回日本肝臓学会総会大会
  • Place of Presentation: 東京，東京フォーラム
  • Year and Date: 2015-10-08
• [Presentation] NASH自然発症マウスにおける腸内環境の変化と発症機序との関係. (2015)
  • Author(s): 秋山健太郎，池内美穂，青山希，蕨栄治，正田純一.
  • Organizer: 第101回日本消化器病学会総会
  • Place of Presentation: 仙台，仙台国際会議場
  • Year and Date: 2015-04-23
• [Presentation] 筋萎縮予防法ハイブリッド訓練の女性NAFLD患者に対する有用性の検討 (2015)
  • Author(s): 丸山 剛，呉 世昶，志田隆史，新井恵美，志波直人，正田純一
  • Organizer: 第163回日本体力医学会関東地方会
  • Place of Presentation: 東京
  • Year and Date: 2015-02-28
• [Presentation] 肥満者におけるirisinの分泌動態と身体活動量の関連性 (2015)
  • Author(s): 蘇 リナ，呉 世昶，志田隆史，辻本健彦，田中喜代次，正田純一
  • Organizer: 第163回日本体力医学会関東地方会
  • Place of Presentation: 東京
  • Year and Date: 2015-02-28
• [Presentation] 非アルコール性脂肪性肝疾患に対する３次元加速度トレーニングの効果 (2014)
  • Author(s): 丸山 剛，呉 世昶，佐治朱美，染谷典子，志田隆史，新井恵美，磯辺智範，岡本嘉一，正田純一
  • Organizer: 第162回日本体力医学会関東地方会
  • Place of Presentation: 東京
  • Year and Date: 2014-12-20
• [Presentation] 非アルコール性脂肪性肝疾患における新規筋由来生理活性物質Irisinの分泌動態と病態因子との関連性 (2014)
  • Author(s): 蘇 リナ，志田隆史，正田純一
  • Organizer: 第40回日本肝臓学会東部会
  • Place of Presentation: 東京
  • Year and Date: 2014-11-27 – 2014-11-28
• [Presentation] 肥満者の肝臓，筋肉，インスリン抵抗性：運動の効果 (2014)
  • Author(s): 正田純一
  • Organizer: Metabolic Syndrome と肝疾患研究会
  • Place of Presentation: 東京
  • Year and Date: 2014-11-15
• [Presentation] NAFLDを有する肥満者に対する加速度トレーニングの臨床的有用性 (2014)
  • Author(s): 澤井朱美，呉 世昶，白木 仁，田中喜代次，正田純一
  • Organizer: 第25回臨床スポーツ医学会
  • Place of Presentation: 東京
  • Year and Date: 2014-11-08 – 2014-11-09
• [Presentation] Moderate-Vigorous Physical Activity (MVPA) Volume in a Week is an Important Factor for Management of Non-Alcoholic Fatty Liver Disease: A Retrospective Study. (2014)
  • Author(s): Oh S, Shida T, So R, Tsujimoto T, Tanaka K, Shoda J
  • Organizer: The 65th Annual Meeting of the American Association for the Study of Liver Disesaes
  • Place of Presentation: Boston
  • Year and Date: 2014-11-07 – 2014-11-11
• [Presentation] Deletion of both p62 and Nrf2 spontaneously leads to development of steatohepatitis in mice. (2014)
  • Author(s): Akiyama K, Warabi E, Okada K, Ikeuchi M, Kose K, Shoda J
  • Organizer: The 65th Annual Meeting of the American Association for the Study of Liver Disesaes
  • Place of Presentation: Boston
  • Year and Date: 2014-11-07 – 2014-11-11
• [Presentation] Irisin is associated with physical activity and hepatic steatosis in non-alcoholic fatty disease patients. (2014)
  • Author(s): So R, Oh S, Shida T, Tanaka K, Shoda J
  • Organizer: The 65th Annual Meeting of the American Association for the Study of Liver Disesaes
  • Place of Presentation: Boston
  • Year and Date: 2014-11-07 – 2014-11-11
• [Presentation] 肥満者の肝臓，筋肉，インスリン抵抗性：運動の効果 (2014)
  • Author(s): 正田純一
  • Organizer: 第10回愛媛軽症糖尿病懇話会
  • Place of Presentation: 愛媛
  • Year and Date: 2014-10-31
• [Presentation] 非アルコール性脂肪性肝疾患を有する肥満者における新しいレジスタンス運動の臨床的有用性 (2014)
  • Author(s): 呉 世昶，田中喜代次，正田純一
  • Organizer: 第18回日本肝臓学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2014-10-23 – 2014-10-26
• [Presentation] 非アルコール性脂肪性肝炎（NASH）自然発症モデルマウスにおける腸肝相関からみた病態評価と機序の解明 (2014)
  • Author(s): 秋山健太郎，蕨 栄治，正田純一
  • Organizer: 第18回日本肝臓学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2014-10-23 – 2014-10-26
• [Presentation] NAFLD肥満者における中高強度身体活動量の増加が血中脂肪酸組成に及ぼす影響について (2014)
  • Author(s): 呉 世昶，田中喜代次，蘇 リナ，加藤千晶，澤井朱美，正田純一
  • Organizer: 第18回日本肝臓学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2014-10-23 – 2014-10-26
• [Presentation] HER3陽性の胆道癌に対する分子標的治療pertuzumabの効果 (2014)
  • Author(s): 川本 徹，山本雅一，正田純一
  • Organizer: 第56回日本消化器病学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2014-10-23 – 2014-10-26
• [Presentation] 胆道癌における高感度診断システムの開発：新しい腫瘍マーカーとしてのWFA-sialyl MUC1の意義 (2014)
  • Author(s): 樋口亮太，正田純一，山本雅一
  • Organizer: 第50回日本胆道学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2014-09-26 – 2014-09-27
• [Presentation] 肥満者の肝臓，筋肉，インスリン抵抗性：運動の効果 シンポジウム「メデイカルフィットネス：過去，現在，未来」 (2014)
  • Author(s): 正田純一
  • Organizer: 第69回日本体力医学会大会
  • Place of Presentation: 長崎
  • Year and Date: 2014-09-19 – 2014-09-21
• [Presentation] 減量による血中Irisin濃度の変動が肥満病態の改善に及ぼす影響 (2014)
  • Author(s): 蘇 リナ，辻本健彦，呉 世昶，金 甫建，蕨 栄治，田中喜代次，正田 純一
  • Organizer: 第69回日本体力医学会大会
  • Place of Presentation: 長崎
  • Year and Date: 2014-09-19 – 2014-09-21
• [Presentation] 肥満予防を目的とした全身振動刺激の有用性の基礎的検討 (2014)
  • Author(s): 堀江正樹，小峰昇一，蘇 リナ，蕨 栄治，正田純一
  • Organizer: 第69回日本体力医学会大会
  • Place of Presentation: 長崎
  • Year and Date: 2014-09-19 – 2014-09-21
• [Presentation] 運動による肝・骨格筋におけるNrf2活性化の解析 (2014)
  • Author(s): 小峰昇一，蕨栄治，呉 世昶，堀江正樹，岩脇隆夫，正田純一
  • Organizer: 第69回日本体力医学会大会
  • Place of Presentation: 長崎
  • Year and Date: 2014-09-19 – 2014-09-21
• [Presentation] NAFLD肥満成人男性の肝および代謝異常の改善を目指した適切な身体活動量の検討 (2014)
  • Author(s): 呉 世昶，田中喜代次，正田純一
  • Organizer: 第33回日本臨床運動療法学会
  • Place of Presentation: 大阪
  • Year and Date: 2014-09-06
• [Presentation] 肥満・生活習慣病と胆道疾患（胆石・胆道がん）シンポジウム「生活習慣が消化器がんの発生に与える影響：最近の知見」 (2014)
  • Author(s): 正田純一
  • Organizer: 第52回日本癌治療学会
  • Place of Presentation: 横浜
  • Year and Date: 2014-08-28 – 2014-08-30
• [Presentation] Clinical benefits of acceleration training for management of obese subjects with non-alcoholic fatty liver disease. (2014)
  • Author(s): Oh S, Shida T, Sawai A, Eguchi K, Maruyama T, So T, Komine S, Horie M, Akiyama K, Tanaka K, Shoda J
  • Organizer: INCHEON ASIAN GAMES INTERNATIONAL SPORT SCIENCE CONGRESS (Korea)
  • Place of Presentation: Korea
  • Year and Date: 2014-08-20 – 2014-08-22
• [Presentation] 胆管がん患者血清中MUC1 の比較糖鎖プロファイリング (2014)
  • Author(s): 松田厚志，久野 敦，中川知美，池原 譲，入村達郎，正田純一，成松 久
  • Organizer: 第12回日本プロテオーム学会
  • Place of Presentation: つくば
  • Year and Date: 2014-07-17 – 2014-07-18
• [Presentation] 座談会「NASH の最近の知見 基礎と臨床」 (2014)
  • Author(s): 正田純一，竹井謙之，橋本悦子
  • Organizer: 最新医学社 座談会
  • Place of Presentation: 東京
  • Year and Date: 2014-06-30
• [Presentation] 肥満・生活習慣病と肝疾患 ― その対策 (2014)
  • Author(s): 正田純一
  • Organizer: 消化器と生活習慣病フォーラム
  • Place of Presentation: つくば
  • Year and Date: 2014-06-20
• [Presentation] 肥満と肝臓病 - 加速度トレーニングの臨床的有用性 (2014)
  • Author(s): 正田純一
  • Organizer: プロテイアジャパン主催情報交換会
  • Place of Presentation: 東京
  • Year and Date: 2014-06-13
• [Presentation] 非アルコール性脂肪性肝疾患（NAFLD）における効果的な運動療法のための適切な身体活動量の検討 (2014)
  • Author(s): 呉世昶，山岸良匡，田中喜代次，正田純一
  • Organizer: 第22回肝病態生理研究会
  • Place of Presentation: 東京
  • Year and Date: 2014-05-31
• [Presentation] 非アルコール性脂肪性肝疾患（NAFLD）における中高度肥満と糖尿病が肝病態に及す影響 (2014)
  • Author(s): 志田隆史，小野塚太郎，呉 世昶，磯辺智範，岡本嘉一，矢藤 繁，島野 仁，正田純一
  • Organizer: 第22回肝病態生理研究会
  • Place of Presentation: 東京
  • Year and Date: 2014-05-31
• [Presentation] NASH自然発症モデルマウスにおける腸肝相関よりみたNASH発症とその進展機序の解析 (2014)
  • Author(s): 秋山健太郎，蕨 栄治，池内美穂，後藤直弘，拝師智之，巨瀬勝美，正田純一
  • Organizer: 第22回肝病態生理研究会
  • Place of Presentation: 東京
  • Year and Date: 2014-05-31
• [Presentation] p62およびNrf2遺伝子の二重欠損マウスにおけるNASH発症機序の解明―肝と腸管の臓器連関の観点より (2014)
  • Author(s): 秋山健太郎，蕨 栄治，池内美穂，後藤直弘，拝師智之，巨瀬勝美，正田純一
  • Organizer: 第50回日本肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 2014-05-29 – 2014-05-30
• [Presentation] 非アルコール性脂肪性肝疾患（NAFLD）における中高度肥満と糖尿病が肝病態に及す影響と病態関連因子の解析 (2014)
  • Author(s): 志田隆史，小野塚太郎，呉 世昶，磯辺智範，岡本嘉一，矢藤 繁，島野 仁，正田純一
  • Organizer: 第50回日本肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 2014-05-29 – 2014-05-30
• [Presentation] NAFLD肥満者に効果的な運動療法を実践するための中高強度身体活動量の検討 (2014)
  • Author(s): 呉世昶, 田中喜代次, 正田純一
  • Organizer: 第50回日本肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 2014-05-29 – 2014-05-30
• [Presentation] 脂肪肝合併2型糖尿病患者における血中脂肪酸組成と肝弾性度・脂肪量の関係についての検討 (2014)
  • Author(s): 矢藤 繁，志田隆史，正田純一，松坂 賢，岩崎 仁，小林和人，鈴木浩明，島野 仁
  • Organizer: 糖尿病学会
  • Place of Presentation: 大阪
  • Year and Date: 2014-05-22 – 2014-05-24
• [Presentation] Non-invasive assessment of ectopic fat in non-alcoholic fatty liver disease using 1H-MRS (2014)
  • Author(s): Isobe T, Okamoto Y, Shida T, Hirano Y, Sato E, Shoda J
  • Organizer: The 23rd Annual Meeting of the Section of Magnetic Resonance Technologists.
  • Place of Presentation: Italy
  • Year and Date: 2014-05-10 – 2014-05-11
• [Presentation] 肥満と糖尿病が肝脂肪化と線維化に及す影響と病態関連因子の解析 (2014)
  • Author(s): 志田隆史，小野塚太郎，呉 世昶，磯辺智範，岡本嘉一，矢藤 繁，島野 仁，正田純一
  • Organizer: 第87回日本超音波医学会
  • Place of Presentation: 横浜
  • Year and Date: 2014-05-09 – 2014-05-11
• [Presentation] 非アルコール性脂肪性肝疾患（NAFLD）における最適な運動療法の検討 (2014)
  • Author(s): 呉世昶，田中喜代次，正田純一
  • Organizer: 第100回日本消化器病学会
  • Place of Presentation: 東京
  • Year and Date: 2014-04-23 – 2014-04-26
• [Presentation] p62およびNrf2遺伝子の二重欠損マウスにおける腸管相関よりみたNASH発症機序の解明 (2014)
  • Author(s): 蕨 栄治，秋山健太郎，正田純一
  • Organizer: 第100回日本消化器病学会
  • Place of Presentation: 東京
  • Year and Date: 2014-04-23 – 2014-04-26
• [Presentation] 運動実践は転写因子Nrf2の賦活化し非アルコール性脂肪性肝疾患の肝病態を改善する (2013)
  • Author(s): 呉 世昶，田中喜代次，加藤千秋，正田純一
  • Organizer: 第49回日本肝臓学会総会
  • Place of Presentation: 東京
• [Presentation] ：過食肥満により脂肪性肝炎を自然発症するp62/Nrf2遺伝子二重欠失マウスの腸管病変とその病態的意義 (2013)
  • Author(s): 秋山健太郎，池田 瑛，蕨 栄治，正田純一
  • Organizer: 第49回日本肝臓学会総会
  • Place of Presentation: 東京
• [Presentation] 非アルコール性脂肪性肝疾患におけるControlled Attenuation Parameterの有用性の検討 (2013)
  • Author(s): 志田隆史，磯辺智範，岡本嘉一，上牧 隆，正田純一
  • Organizer: 第86回日本超音波医学会
  • Place of Presentation: 大阪
• [Presentation] 筋萎縮予防法ハイブリッド訓練の女性NAFLD患者に対する有用性の検討 (2013)
  • Author(s): 小野塚太郎，志田隆史，丸山 剛，江口 清，志波直人，正田純一
  • Organizer: 第68回日本体力医学会
  • Place of Presentation: 東京
• [Presentation] 肥満者女性に対する加速トレーニングの効果についての予備検討 (2013)
  • Author(s): 正田純一，小野塚太郎，志田隆史，丸山 剛，江口 清
  • Organizer: 第68回日本体力医学会
  • Place of Presentation: 東京
• [Presentation] p62:Nrf2遺伝子二重欠損マウスは過食によりNASHを自然発症する (2013)
  • Author(s): 蕨 栄治，秋山健太郎，正田純一
  • Organizer: 第17回日本肝臓学会大会
  • Place of Presentation: 東京
• [Presentation] 胆道疾患 - 肥満・生活習慣病と胆道疾患 (2013)
  • Author(s): 正田純一
  • Organizer: 第49回日本肝臓学会総会 教育講演
  • Place of Presentation: 東京
  • Invited
• [Presentation] 運動と内科疾患～運動療法の有益性と不利益性の境界～ 肥満・生活習慣病と肝胆道疾患，運動療法による予防と治療 (2013)
  • Author(s): 正田純一，田中喜代次
  • Organizer: 第68回日本体力医学会
  • Place of Presentation: 東京
  • Invited
• [Book] 消化器疾患最新の治療 (2015)
  • Author(s): 鈴木英雄、溝上裕士
  • Total Pages: 3
  • Publisher: 南江堂
• [Book] 胆汁酸とその分画 新・検査値のみかた (2015)
  • Author(s): 正田純一
  • Total Pages: 2
  • Publisher: 中外医学社
• [Book] 新しい診断と治療のABC 6 消化性潰瘍 (2014)
  • Author(s): 鈴木英雄、溝上裕士、奈良坂俊明、金子剛、兵頭一之介
  • Total Pages: 6
  • Publisher: 最新医学社
• [Book] Epidemiology and Pathogenesis of Hepatocellular Carcinoma. In: Hepatocellular Carcinoma. (2014)
  • Author(s): Shoda, J., Ohokohchi, N.
  • Total Pages: 23
  • Publisher: NOVA Science Publishers
• [Book] 肝内胆管癌の新規バイオマーカー (2014)
  • Author(s): 正田純一，松田厚志，久野 敦，池原 譲，成松 久，大河内信弘，山本雅一，中沼安二
  • Total Pages: 3
  • Publisher: Hepatology Practice 文光堂
• [Book] 生活習慣と胆道癌-胆管癌集団発症への対策も含めて Annual Review 消化器 2014 (2014)
  • Author(s): 正田純一
  • Total Pages: 5
  • Publisher: 中外医学社
• [Book] 医学のあゆみ 分子スポーツ医学 (2013)
  • Author(s): 正田純一
  • Total Pages: 458
  • Publisher: 医歯薬出版