Fasting-induced transcription factor CREBH ameliorates obesity via entero-hepatic circulation
| Project/Area Number |
25282214
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
Nakagawa Yoshimi 筑波大学, 国際統合睡眠医科学研究機構, 准教授 (80361351)
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| Co-Investigator(Kenkyū-buntansha) |
Shimano Hitoshi 筑波大学, 医学医療系, 教授 (20251241)
Matsuzaka Takashi 筑波大学, 医学医療系, 准教授 (70400679)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2015: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | 生活習慣病 / CREBH / ゲノム編集 / 肥満 / 糖尿病 / 遺伝子発現 / 動脈硬化 / 非アルコール性脂肪肝 / 転写調節 / 脂質代謝 |
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| Outline of Final Research Achievements |
CREBH is a transcription factor, which is expressed in liver and intestine. Liver-specific CREBH Tg mice were generated, which suppressed diet-induced obesity and diabetes. CREBH and PPARα synergistically regulated hepatic FGF21 expression. CREBH KO mice showed atherosclerosis and non-alcoholic fatty liver disease. Conversely, CREBH Tg suppressed atherosclerosis. Using CRISPR/Cas9 system, we firstly generated liver-specific CREBH knockout mice, which exhibited non-alcoholic fatty liver disease, suggesting that liver CREBH, but not intestine CREBH, is important for the pathology of non-alcoholic fatty liver disease
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Hepatic CREB3L3 Controls Whole-Body Energy Homeostasis and Improves Obesity and Diabetes2014
Author(s)
Yoshimi Nakagawa,* Aoi Satoh,* Sachiko Yabe,* Mika Furusawa, Naoko Tokushige, Hitomi Tezuka, Motoki Mikami, Wakiko Iwata, Akiko Shingyouchi, Takashi Matsuzaka, Shiori Kiwata, Yuri Fujimoto, Yasushi Kawakami, Osamu Urayama, Nobuhiro Yamada, and Hitoshi Shimano et. al
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Journal Title
Endocrinology
Volume: 155(12)
Issue: 12
Pages: 4706-4719
DOI
Related Report
Peer Reviewed
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