Effect of exercise performed at different time of day on 24 h fat oxidation.

• Project/Area Number: 25282215
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: University of Tsukuba
• Principal Investigator: TOKUYAMA Kumpei 筑波大学, 体育系, 教授 (00207565)
• Co-Investigator(Kenkyū-buntansha): OMI Naomi 筑波大学, 体育系, 准教授 (10300005) ; OGATA Hitomi 筑波大学, 体育系, 特別研究員(RPD) (80455930) ; NABEKURA Yoshiharu 筑波大学, 体育系, 教授 (60237584) ; SATOH Makoto 筑波大学, 国際統合睡眠医科学研究機構, 教授 (50242409)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000); Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2014: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2013: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
• Keywords: ヒューマンカロリメータ / ヒューマン・カロリメータ / 朝練習 / ２４時間の脂肪酸化 / 性差 / 生活習慣 / 肥満 / 脂肪酸化

Outline of Final Research Achievements

The present study compared the effect of exercise performed at various time of the day, including before breakfast, after breakfast, after lunch or after dinner, measuring 24 h fat oxidation by whole room metabolic chamber. A bout of endurance exercise at moderate intensity increases 24 h fat oxidation in male and female subjects, only when performed before breakfast. Time course of relative energy (carbohydrate) balances, calculated from time course of energy expenditure (carbohydrate oxidation) and time of meals, revealed a transient energy (carbohydrate) decrease after morning exercise. The magnitude of transient decrease in body energy (carbohydrate) content was correlated to 24 h fat oxidation. The present results are consistent with the notion that tissue glycogen functions not only as carbohydrate reserve but also as molecular sensor capable of activating signaling pathways in response to exercise responsible for an increase in fat oxidation.

Research Products

• [Journal Article] Transient energy deficit induced by exercise increases 24-h fat oxidation in young trained men. (2015)
  • Author(s): Kaito Iwayama, Ryosuke Kawabuchi, Insung Park, Reiko Kurihara, Masashi Kobayashi, Masanobu Hibi, Sachiko Oishi, Koichi Yasunaga, Hitomi Ogata, Yoshiharu Nabekura, Kumpei Tokuyama
  • Journal Title: J Appl Physiol. Volume: 118 Pages: 80-85
  • DOI: 10.1152/japplphysiol.00697.2014
  • Peer Reviewed / Open Access
• [Journal Article] Exercise increases 24-h fat oxidation only when it is performed before breakfast. (2015)
  • Author(s): Kaito Iwayama, Reiko Kurihara, Yoshiharu Nabekura, Ryosuke Kawabuchi, Insung Park, Masashi Kobayashi, Hitomi Ogata, Momoko Kayaba, Makoto Satoh, Kumpei Tokuyama
  • Journal Title: EBioMedicine Volume: 2 Pages: 2003-2009
  • DOI: 10.1016/j.ebiom.2015.10.029
  • Peer Reviewed / Open Access
• [Journal Article] Transient energy deficit induced by exercise increases 24-h fat oxidation in young trained men. (2015)
  • Author(s): Iwayama K, Kawabuchi R, Park I, Kurihara R, Kobayashi M, Hibi M, Oishi S, Yasunaga K, Ogata H, Nabekura Y, Tokuyama K.
  • Journal Title: J Appl Physiol. Volume: 118 Pages: 80-85
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Continuous glucose monitoring during a 100 km race – A case study in an elite ultra-marathon runner. (2015)
  • Author(s): Sengoku,Y., K.Nakamura, H.Ogata, Y.Nabekura, S.Nagasaka, K.Tokuyama.
  • Journal Title: Int J Sports Physiol. Perform. Volume: 10 Pages: 124-127
  • Peer Reviewed / Open Access
• [Journal Article] LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance. (2014)
  • Author(s): Lan F, Misu H, Chikamoto K, Takayama H, Kikuchi A, Mohri K, Takata N, Hayashi H, Matsuzawa-Nagata N, Takeshita Y, Noda H, Matsumoto Y, Ota T, Nagano T, Nakagen M, Miyamoto K, Takatsuki K, Seo T, Iwayama K, Tokuyama K, Matsugo S, Tang H, Saito Y, Yamagoe S, Kaneko S, Takamura T.
  • Journal Title: Diabetes Volume: 63 Pages: 1649-1664
  • NAID: 120005440333
  • Peer Reviewed / Open Access
• [Journal Article] Association of IL-15 with peripheral and hepatic insulin sensitivity in healthy middle-aged men. (2014)
  • Author(s): Nishida Y., K.Tokuyama, S.Nagasaka, A.Kiyonaga, Y.Higaki, M.Hara, K.Tanaka, H.Tanaka.
  • Journal Title: Open Journal of Endocrine and Metabolic Diseases. Volume: 4 Pages: 59-67
  • Peer Reviewed / Open Access
• [Journal Article] Human calorimetery: Energy expenditure and substrate utilization measurements using a respiratory chamber. (2013)
  • Author(s): Hibi M., T.Ando, S.Tanaka and K.Tokuyama.
  • Journal Title: J Physical Fitness Sports Medicine. Volume: 2 Pages: 93-100
  • Peer Reviewed
• [Journal Article] Effect of exercise performed before or after breakfast on 24h fat oxidation. (2013)
  • Author(s): Shimada K, Y.Yamamoto, K.Iwayama, K.Nakamura, S.Yamaguchi, M.Hibi, Y.Nabekura, K.Tokuyama.
  • Journal Title: Metabolism. 62:793-800, 2013. Volume: 62 Pages: 793-800
  • Peer Reviewed
• [Presentation] Does breakfast matter endurance performance for athletes? (2016)
  • Author(s): Tokuyama K
  • Organizer: ENHS 2016
  • Place of Presentation: Kohn Kaen Convention Center, Kohn Kaen, Thailand
  • Year and Date: 2016-01-22
  • Int'l Joint Research / Invited
• [Presentation] Exercise acts as fat burning pills if it is taken before breakfast. (2015)
  • Author(s): Iwayama K., Y.Nabekura, R.Kurihara, R.Kawabuchi, I.Park, H.Ogata, A.Ogawa, A.Ando, M.Kayaba, K.Tokuyama.
  • Organizer: Cell Symposia “Exercise Metabolism”
  • Place of Presentation: NH Grand Hotel Kranspolsky, Amsterdam, Nederland
  • Year and Date: 2015-07-12
  • Int'l Joint Research
• [Presentation] Effects of exercise on 24-h fat oxidation depend on when it is performed. (2013)
  • Author(s): Kumpei Tokuyama, Kaito Iwayama, Reiko Kurihara, Ryousuke Kawabuchi, Insung Park, Hitomi Ogata, Nana Kurosawa, Masashi Kobayashi, Kazuteru Nakamura, Yoshiharu Nabekura.
  • Organizer: 5th International Sports Science Congress in Memory of the 1988 Seoul Olympic Games.
  • Place of Presentation: Suwon University, Suwon, Korea
  • Invited
• [Presentation] Timing of exercise relative to meal ingestion affects 24 hours fat oxidation. (2013)
  • Author(s): Iwayama K., P.Insong, R.Kawabuchi, R.Kurihara, M.Kobayashi, H.Masanobu, S.Yamaguchi, Y.Nabekura, H.Ogata, N.Omi, K.Tokuyama.
  • Organizer: Obesity week 2013
  • Place of Presentation: Georgia World Congress Center,Atlanta, USA
• [Presentation] Effects of exercise on 24-h fat oxidation depend on when it is performed. (2013)
  • Author(s): Kurihara.R, K.Iwayama, H.Ogata, I.Park, R.Kawabuchi, Y.Nabekura, M.Kobayashi, S.Yamaguchi, M.Hibi, K.Tokuyama. 1
  • Organizer: 9th Annual Congress of the European College of Sport Science.
  • Place of Presentation: National Institute of Physical Education of Catalunya,Barcelona, Spain
• [Presentation] “いつ”運動するかが24時間の脂質酸化量に影響する (2013)
  • Author(s): 岩山海渡、朴寅成、川渕良輔、栗原玲子、小林優史、日比壮信、山口幸子、鍋倉賢治、徳山薫平
  • Organizer: 第34回日本肥満学会
  • Place of Presentation: 東京国際フオーラム、東京都千代田区