A study for elucidating mechanisms underlying preventive effects of physical activity/exercise training on colon cancer

• Project/Area Number: 25282219
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Ritsumeikan University
• Principal Investigator: Tabata Izumi 立命館大学, スポーツ健康科学部, 教授 (20188402)
• Research Collaborator: Matsuo Kaori ; Sato Koji ; Higashida Kazuhiko ; Miyamoto Eri ; Iemitsu Motoyuki ; Hamaoka Takahumi ; Suemoto Ken ; Tsuji Katsunori ; Xu Yuzhong ; Liu Xin
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2013: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
• Keywords: 大腸がん / 身体活動 / 運動トレーニング / ACF / SPARC / 高強度運動 / 大腿四頭筋 / 健康増進科学 / 癌 / 運動 / ＡＩＣＡＲ / ＳＰＡＲＣ

Outline of Final Research Achievements

By conducting experiments inculuding in vitro study to human training study, we found a mehanism underlying preventive effects of exercise training, especially high intensity intermittent exercise training, on colon cancer development as folows.
First, high intensity intermittent exercise elevated AMPK whose activitiy is exercise-intensity dependent, Second, AMPK activation enahces PGC1α expression in exercised muscle. Third, PGC1αinduced SPARC protein. Forth, this increased expression of SPARC elvated its serum concentrataion after exercise.The incrased concentration of SPARC which is kwnon to induce aptosis of pre-cancer cell of ACF in colon may reduce risk of developing colon cancer.

Research Products

• [Journal Article] A Mechanism Underlying Preventive Effect of High-Intensity Training on Colon Cancer. (2017)
  • Author(s): Matsuo K, Sato K, Suemoto K, Miyamoto-Mikami E, Fuku N, Higashida K, Tsuji K, Xu Y, Liu X, Iemitsu M, Hamaoka T, Tabata I.
  • Journal Title: Medicine and Science in Sports and Exercise Volume: 印刷中 Issue: 9 Pages: 1805-1816
  • DOI: 10.1249/mss.0000000000001312
  • Peer Reviewed
• [Journal Article] タバタトレーニング-その理論と発展- (2016)
  • Author(s): 田畑泉
  • Journal Title: 日本スポーツ栄養学会雑誌 Volume: 9 Pages: 2-8
  • NAID: 40022673435
  • Peer Reviewed
• [Journal Article] Endurance training-induced increase in circulating irisin levels is associated with reduction of abdominal visceral fat in middle-aged and older adults. (2015)
  • Author(s): Miyamoto-Mikami E, Sato K, Kurihara T, Hasegawa N, Fujie S, Fujita S, Sanada K, Hamaoka T, Tabata I, Iemitsu M.
  • Journal Title: PLoS One Volume: 10 Issue: 3 Pages: e0120354-e0120354
  • DOI: 10.1371/journal.pone.0120354
  • NAID: 120006352261
  • Peer Reviewed / Open Access
• [Journal Article] Light-intensity physical activity is associated with insulin resistance in elderly Japanese women independent of moderate- to vigorous-intensity physical activity. (2014)
  • Author(s): Gando Y, H Murakami, R Kawakami, N Tanaka, K Sanada, I Tabata, M Higuchi, M Miyachi.
  • Journal Title: Journal of Physical Activity and Health Volume: 11 Pages: 266-271
  • Peer Reviewed
• [Journal Article] Association between serum 25-hydroxyvitamin D and inflammatory cytokines in healthy adults. (2014)
  • Author(s): Sun X, Z-B Cao , Y Zhang, Y Ishimi, I Tabata, M Higuchi.
  • Journal Title: Nutrients Volume: 6 Pages: 221-230
  • Peer Reviewed
• [Presentation] The rise of Tabata training and why it works. Work Shop (2016)
  • Author(s): Tabata I
  • Organizer: The 7th Asia Conference of Kinesiology
  • Place of Presentation: Inchon, Korea
  • Year and Date: 2016-11-13
  • Int'l Joint Research / Invited
• [Presentation] 高強度短時間間欠的トレーニングに対する骨格筋遺伝子発現変動の網羅的解析 (2016)
  • Author(s): 宮本(三上)恵里、街勝憲、長谷川夏輝、藤江隼平、浜岡隆文、金久博昭、田畑泉、家光素行
  • Organizer: 第７１回日本体力医学会大会
  • Place of Presentation: アイーナ 岩手県盛岡市
  • Year and Date: 2016-09-23
• [Presentation] 疲労困憊に至らない高強度・短時間・間欠的クロストレーニングと疲労困憊に至る高強度・短時間・間欠的トレーニングが最大酸素摂取量（VO2max）に及ぼす影響 (2015)
  • Author(s): 徐 宇中、街 勝憲、本間 俊行、栗原 俊之、家光 素行、田畑 泉
  • Organizer: 第70回日本体力医学会大会
  • Place of Presentation: 和歌山県民文化会館（和歌山県和歌山市）
  • Year and Date: 2015-09-19
• [Presentation] 長期的な間欠的短時間高強度運動およびクロレラ摂取による無酸素性運動能力と骨格筋の解糖系代謝調節の併用効果 (2015)
  • Author(s): 堀居直希,佐藤幸治,長谷川夏輝, 藤江隼平, 溝口 亨, 大西真人,田畑泉,家光素行
  • Organizer: 第70回日本体力医学会大会
  • Place of Presentation: 和歌山県民文化会館（和歌山県和歌山市）
  • Year and Date: 2015-09-19
• [Presentation] タバタトレーニング ～その理論と発展～ (2015)
  • Author(s): 田畑泉
  • Organizer: 日本スポーツ栄養学会 第2回大会
  • Place of Presentation: 立命館大学（滋賀県草津市）
  • Year and Date: 2015-07-04
  • Invited
• [Presentation] 身体活動・運動と骨粗鬆症 (2015)
  • Author(s): 田畑泉
  • Organizer: 第27回北海道骨粗鬆症研究会学術集会
  • Place of Presentation: 北海道大学（北海道）
  • Year and Date: 2015-02-07
  • Invited
• [Presentation] 高強度クロス運動トレーニングが糖負荷試験成績に与える影響に関する研究 (2015)
  • Author(s): 田畑泉、佐藤幸治、宮本恵理、街勝憲、徐宇中、家光素行
  • Organizer: 第29回日本体力医学会近畿地方会
  • Place of Presentation: 同志社大学(京都府）
  • Year and Date: 2015-01-24
• [Presentation] 高強度・短時間・間欠的運動が運動後過剰酸素消費量に与える影響 (2014)
  • Author(s): 街勝憲、徐宇中、田畑泉
  • Organizer: 第６９回日本体力医学会大会
  • Place of Presentation: 長崎大学（長崎県）
  • Year and Date: 2014-09-20
• [Presentation] 高強度・短時間・間欠的クロス運動トレーニングが有酸素性及び無酸素性エネルギー供給機構に与 える影響 (2014)
  • Author(s): 徐宇中、街勝憲、田畑泉
  • Organizer: 第６９回日本体力医学会大会
  • Place of Presentation: 長崎大学（長崎県）
  • Year and Date: 2014-09-19
• [Presentation] 高強度・短時間・間欠的トレーニングについて (2014)
  • Author(s): 田畑泉
  • Organizer: 教育講演.第22回日本運動生理学会大会
  • Place of Presentation: 川崎医療福祉大学（岡山県）
  • Year and Date: 2014-07-19
  • Invited
• [Book] タバタ式トレーニング～究極の科学的肉体改造メソッド～ (2015)
  • Author(s): 田畑泉
  • Total Pages: 127
  • Publisher: 扶桑社
• [Funded Workshop] annual meeting of the American College of Sport Medicine (2016)
  • Place of Presentation: Boston （USA)
  • Year and Date: 2016-05-31