| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
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| Outline of Final Research Achievements |
By conducting experiments inculuding in vitro study to human training study, we found a mehanism underlying preventive effects of exercise training, especially high intensity intermittent exercise training, on colon cancer development as folows.
First, high intensity intermittent exercise elevated AMPK whose activitiy is exercise-intensity dependent, Second, AMPK activation enahces PGC1α expression in exercised muscle. Third, PGC1αinduced SPARC protein. Forth, this increased expression of SPARC elvated its serum concentrataion after exercise.The incrased concentration of SPARC which is kwnon to induce aptosis of pre-cancer cell of ACF in colon may reduce risk of developing colon cancer.
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