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Effects of well-rounded exercise training on cartilage metabolism evaluated by systemic biomarkers

Research Project

Project/Area Number 25282220
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Applied health science
Research InstitutionFoundation for Biomedical Research and Innovation

Principal Investigator

Yasuda Tadashi  公益財団法人先端医療振興財団, その他部局等, 研究員 (40314223)

Co-Investigator(Kenkyū-buntansha) NAKATANI Toshiaki  天理大学, 体育学部, 教授 (60248185)
TSUBOYAMA Tadao  京都大学, 医学研究科, 教授 (90261221)
ARAI Hidenori  京都大学, 医学研究科, 教授 (60232021)
MATSUDA Shuichi  京都大学, 医学研究科, 教授 (40294938)
ITO Hiromu  京都大学, 医学研究科, 准教授 (70397537)
Research Collaborator MATSUDA Makoto  
AZUKIZAWA Masayuki  
HAMAMOTO Yosuke  
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Keywordsリハビリテーション / 運動療法 / 変形性膝関節症 / バイオマーカー / 軟骨代謝
Outline of Final Research Achievements

We evaluated the effects of exercise training on cartilage metabolism by systemic biomarkers. Females were classified into pre-radiologically defined osteoarthritis [Kellgren-Lawrence (K-L) grade<2] or radiologically defined osteoarthritis (K-L grade>1). After a combination of aerobic, resistance, flexibility, and balance exercise trainings was assigned for 90 minutes once a week during 12 weeks, they were followed up during subsequent 12 weeks. In K-L<2 group (n=23), the training resulted in a significant decrease in the collagen degradation evaluated by carboxy-telopeptide of type II collagen at 1, 2, 4, 8, and 24 weeks as well as by collagenase-generated neoepitope of type II collagen at 12, 20, 24 weeks. In K-L>1 group (n=8), no favorable effect by the training was found on cartilage metabolism evaluated by the biomarkers of type II collagen, whereas cartilage oligomeric matrix protein (degradation marker) increased at 1, 2, 20, and 24 weeks after the initiation of intervention.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (1 results)

All 2016

All Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] EFFECT OF AN EXERCISE THERAPY ON SYSTEMIC BIOMARKERS FOR CARTILAGE METABOLISM2016

    • Author(s)
      M. Azukizawa, H. Ito, T. Yasuda, M. Furu, Y. Hamamoto, T. Fujii, Y. Morita, A. Okahata, K. Masamoto, S. Matsuda
    • Organizer
      European League against Rheumatism Congress 2016
    • Place of Presentation
      英国ロンドン
    • Year and Date
      2016-06-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research

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Published: 2013-05-21   Modified: 2019-07-29  

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