| Project/Area Number |
25282220
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Foundation for Biomedical Research and Innovation |
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Principal Investigator |
Yasuda Tadashi 公益財団法人先端医療振興財団, その他部局等, 研究員 (40314223)
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| Co-Investigator(Kenkyū-buntansha) |
NAKATANI Toshiaki 天理大学, 体育学部, 教授 (60248185)
TSUBOYAMA Tadao 京都大学, 医学研究科, 教授 (90261221)
ARAI Hidenori 京都大学, 医学研究科, 教授 (60232021)
MATSUDA Shuichi 京都大学, 医学研究科, 教授 (40294938)
ITO Hiromu 京都大学, 医学研究科, 准教授 (70397537)
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| Research Collaborator |
MATSUDA Makoto
AZUKIZAWA Masayuki
HAMAMOTO Yosuke
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
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| Keywords | リハビリテーション / 運動療法 / 変形性膝関節症 / バイオマーカー / 軟骨代謝 |
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| Outline of Final Research Achievements |
We evaluated the effects of exercise training on cartilage metabolism by systemic biomarkers. Females were classified into pre-radiologically defined osteoarthritis [Kellgren-Lawrence (K-L) grade<2] or radiologically defined osteoarthritis (K-L grade>1). After a combination of aerobic, resistance, flexibility, and balance exercise trainings was assigned for 90 minutes once a week during 12 weeks, they were followed up during subsequent 12 weeks. In K-L<2 group (n=23), the training resulted in a significant decrease in the collagen degradation evaluated by carboxy-telopeptide of type II collagen at 1, 2, 4, 8, and 24 weeks as well as by collagenase-generated neoepitope of type II collagen at 12, 20, 24 weeks. In K-L>1 group (n=8), no favorable effect by the training was found on cartilage metabolism evaluated by the biomarkers of type II collagen, whereas cartilage oligomeric matrix protein (degradation marker) increased at 1, 2, 20, and 24 weeks after the initiation of intervention.
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