Synthesis and functional analysis of novel biologically active molecules based on complex macrolide natural products
| Project/Area Number |
25282228
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomolecular chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
Sasaki Makoto 東北大学, 生命科学研究科, 教授 (80235267)
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| Co-Investigator(Renkei-kenkyūsha) |
FUWA Haruhiko 東北大学, 大学院生命科学研究科, 准教授 (90359638)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2013: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Keywords | 海洋天然物 / マクロリド / 全合成 / 生体機能分子 / 機能解析 / ゴニオドミンＡ / アンフィジノリドＮ / ポリカバノシドＢ / ゴニオドミンA / ポリカバノシド / アンフィジノリドN / ポリカバノシドB |
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| Outline of Final Research Achievements |
Our research focused on the efficient total synthesis of structurally complex marine macrolide natural products with significant biological activities to investigate and exploit their biological functions. A convergent synthesis of a fully functionalized macrolactone core of goniodomin A, a polyether macrolide that targets actin cytoskeleton, has been accomplished. An efficient, convergent total synthesis of polycavernoside B, a lethal glycosidic macrolide isolated from the red alga, has been achieved for the first time. In addition, efficient synthetic routes to the C1-C13 and C8-C29 fragments of amphidinolide N, an extremely potent cytotoxic macrolide, have been developed in a convergent manner.
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Report
(5 results)
Research Products
(77 results)
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[Journal Article] Tetracyclic Truncated Analogue of the Marine Toxin Gambierol Modifies NMDA, Tau, and Amyloid β Expression in Mice Brains: Implications in AD Pathology2017
Author(s)
Eva Alonso, Andres C. Vieira, Ines Rodoriguez, Rebeca Alvarino, Sandra Gegunde, Haruhiko Fuwa, Yuto Suga, Makoto Sasaki, Amparo Alfonso, Jose Mannuel Cifuentes, Luis M. Botana
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Journal Title
ACS Chemical Neuroscience
Volume: 8
Issue: 6
Pages: 1358-1367
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] ポルチミンの合成研究2017
Author(s)
三好太朗、齋藤真輝、岩崎浩太郎、佐々木 誠
Organizer
日本化学会第97春季年会
Place of Presentation
慶應義塾大学（神奈川県横浜市）
Year and Date
2017-03-18
Related Report
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[Presentation] Synthetic studies on iriomoteolide-2a2015
Author(s)
K. Sakamoto, A. Hakamata, H. Fuwa, and M. Sasaki
Organizer
2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)
Place of Presentation
Honolulu (USA)
Year and Date
2015-12-17
Related Report
Int'l Joint Research
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