| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2016: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
Mice expressing membrane proteins LMP1 and LMP2A derived from EV virus were prepared and their effects were investigated. It was found that LMP2A promotes the differentiation of germinal center B cells into antibody producing cells and contributes to infection of EBV by surviving low affinity B cells. In addition, systemic lupus erythematosus-like symptoms were induced and firstly proved to be associated with autoimmune diseases.In addition, T / NK cells were reduced by using its antibody, and the pathological condition of the mouse was analyzed in the state of immunosuppression. It was found that LMP1 and LMP2A cooperate with each other in germinal center B cells and induce proliferative diseases such as Hodgkin's lymphoma.
The crystallization of the C-terminus region of CTAR1 involved in signal transduction in LMP1 was performed. The complex crystals between CTAR1 and its antibody of 11A1 up to 1.9 A resolution were obtained and the structural analysis is now in progress.
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