Development of RNA medicine based on nano-structured design and templated reaction
| Project/Area Number |
25282240
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical biology
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| Research Institution | Nagoya University (2015)
Hokkaido University |
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Principal Investigator |
ABE HIROSHI 名古屋大学, 理学(系)研究科(研究院), 教授 (80415067)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | RNA / 化学反応 / 免疫応答 / RNA干渉 / 細胞 |
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| Outline of Final Research Achievements |
We developed a new strategy for the buildup reaction of active siRNA species from short RNA fragments in living cells using a chemical ligation reaction. This strategy could decrease undesired immune responses and provide more latitude for RNAi technology in the design and concentration of introduced RNA compared to traditional siRNA methods.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Rolling Circle Translation of Circular RNA in Living Human Cells.2015
Author(s)
N. Abe, K. Matsumoto, M. Nishihara, Y. Nakano, A. Shibata, H. Maruyama, S. Shuto, A. Matsuda, M. Yoshida, Y. Ito, H. Abe
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Journal Title
Scientific Rep
Volume: 15
Issue: 1
Pages: 16435-16435
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Synthesis of 3',4'-difluoro-3'-deoxyribonucleosides and its evaluation of the biological activities: Discovery of a novel type of anti-HCV agent 3',4'-difluorocordycepin2014
Author(s)
Shimada H, Haraguchi K, Hotta K, Miyaike T, Kitagawa Y, Tanaka H, Kaneda R, Abe H, Shuto S, Mori K, Ueda Y, Kato N, Snoeck R, Andrei G, Balzarini J.
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Journal Title
Bioorg. Med. Chem.
Volume: 22
Issue: 21
Pages: 6174-82
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Rolling circle amplification in prokaryotic translation system using small circular RNA.2013
Author(s)
Abe, N., Hiroshima, M., Maruyama, H., Nakashima, Y., Nakano, Y., Matsuda, A., Sako, Y., Ito, Y., and Abe, H.
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Journal Title
Angew. Chem. Int. Ed.
Volume: 52
Issue: 27
Pages: 7004-7008
DOI
Related Report
Peer Reviewed
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