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Brain information processing mechanism of reward-value coding during decision-making

Research Project

Project/Area Number 25282246
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Basic / Social brain science
Research InstitutionUniversity of Tsukuba

Principal Investigator

Shidara Munetaka  筑波大学, 医学医療系, 教授 (10357189)

Co-Investigator(Kenkyū-buntansha) MATSUMOTO NARIHISA  国立研究開発法人産業技術総合研究所, 人間情報研究部門, 主任研究員 (00392663)
HIGO NORIYUKI  国立研究開発法人産業技術総合研究所, 人間情報研究部門, 主任研究員 (80357839)
MATSUDA KEIJI  国立研究開発法人産業技術総合研究所, 人間情報研究部門, 主任研究員 (50358024)
Co-Investigator(Renkei-kenkyūsha) SUGASE YASUKO  国立研究開発法人産業技術総合研究所, 人間情報研究部門, 主任研究員 (40357257)
MIZUHIKI TAKASHI  筑波大学, 医学医療系, 助教 (60463824)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2015: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2014: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Keywords報酬価値 / 行動決定 / 労働負荷 / 労働割引モデル / 眼窩前頭皮質 / 単一ニューロン記録 / アカゲザル / ムシモル / 単一ニューロン活動 / 時間割引モデル / 単一ニューロン / 報酬系 / 自己選択効果
Outline of Final Research Achievements

We investigated information processing mechanism of reward value coding during decision-making by using the task of choosing one of two alternatives that have different work load and reward amount. Neuronal responses in the orbitofrontal cortex had correlation with the difference or summation of values of the two alternatives. Bilateral injection of muscimol into the recording areas induced increase in error rates and choice reaction times during decision-making.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (18 results)

All 2016 2015 2014 Other

All Int'l Joint Research (1 results) Journal Article (4 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (13 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Int'l Joint Research] National Institute of Mental Health(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Small effect of upcoming reward outcomes on visual cue-related neuronal activity in macaque area TE during conditional association2014

    • Author(s)
      K.Ohyama, Y.Sugase-Miyamoto, N.Matsumoto, C.Sato, M.Shidara
    • Journal Title

      Neuroscience Research

      Volume: 88 Pages: 28-38

    • DOI

      10.1016/j.neures.2014.08.004

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Reward expectancy signals in monkey anterior cingulate cortex and its relation to reinforcement learning.2014

    • Author(s)
      Shidara M
    • Journal Title

      Alcohol Alcohol

      Volume: 49 suppl.1 Issue: suppl 1 Pages: i30-i30

    • DOI

      10.1093/alcalc/agu052.148

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Self-choice enhances value in reward-seeking in primates2014

    • Author(s)
      Tsuyoshi Setogawa, Takashi Mizuhiki, Narihisa Matsumoto, Fumika Akizawa, Munetaka Shidara
    • Journal Title

      Neuroscience Research

      Volume: - Pages: 45-54

    • DOI

      10.1016/j.neures.2014.01.004

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 動機付け、報酬期待と腹側線条体(側坐核)2014

    • Author(s)
      設楽宗孝
    • Journal Title

      Clinical Neuroscience

      Volume: 32 Pages: 40-43

    • Related Report
      2013 Annual Research Report
  • [Presentation] Reward value coding by single neuron in the monkey orbitofrontal cortex during decision-making.2016

    • Author(s)
      Setogawa T, Mizuhiki T, Akizawa F, Kuboki R, Richmond BJ, Matsumoto N, Shidara M
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター (北海道札幌市)
    • Year and Date
      2016-03-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] サル眼窩前頭皮質における報酬価値表現2015

    • Author(s)
      Setogawa T, Mizuhiki T, Akizawa F, Kuboki R, Matsumoto N, Shidara M
    • Organizer
      包括脳冬のシンポジウム
    • Place of Presentation
      一橋大学一橋講堂 学術総合センター(東京都千代田区)
    • Year and Date
      2015-12-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] Representation of reward value by single unit in the monkey orbitofrontal cortex during decision-making.2015

    • Author(s)
      Setogawa T, Mizuhiki T, Akizawa F, Kuboki R, Richmond BJ, Matsumoto N, Shidara M
    • Organizer
      45th Annual meeting of the Society for Neuroscience
    • Place of Presentation
      Chicago Convention Center, Chicago, USA
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Representation of reward value by single neuron in the monkey orbitofrontal cortex during decision-making.2015

    • Author(s)
      Setogawa T, Mizuhiki T, Akizawa F, Kuboki R, Matsumoto N, Shidara M
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-07-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] Neuronal activity of dorsal raphe nucleus during reward schedule.2015

    • Author(s)
      Shidara M
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Neuronal activity in the monkey orbitofrontal cortex related to reward value processing during decision-making2015

    • Author(s)
      Setogawa T, Mizuhiki T, Akizawa F, Kuboki R, Matsumoto N, Shidara M
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Single unit activity in the monkey orbitofrontal cortex related to reward value processing during decision-making2014

    • Author(s)
      Setogawa T, Mizuhiki T, Akizawa F, Kuboki R, Matsumoto N, Shidara M.
    • Organizer
      International Symposium “Vision, Memory, Thought: how cognition emerges from neural network”
    • Place of Presentation
      東京
    • Year and Date
      2014-12-06 – 2014-12-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] Single neuronal activity in the monkey orbitofrontal cortex related to reward value processing during decision-making.2014

    • Author(s)
      Setogawa T, Mizuhiki T, Akizawa F, Kuboki R, Matsumoto N, Shidara M
    • Organizer
      44th Annual meeting of the Society for Neuroscience
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Reward expectancy signals in monkey anterior cingulate cortex and its relation to reinforcement learning2014

    • Author(s)
      Shidara M
    • Organizer
      16th International Society of Addiction and Medicine Annual Meeting
    • Place of Presentation
      横浜
    • Year and Date
      2014-10-02 – 2014-10-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Single unit activity in the monkey orbitofrontal cortex related to reward value processing during decision-making2014

    • Author(s)
      Setogawa T, Mizuhiki T, Akizawa F, Kuboki R, Matsumoto N, Shidara M
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Single neuronal activity in the monkey orbitofrontal cortex related to reward value processing during the decision-making schedule task.

    • Author(s)
      Setogawa T, Mizuhiki T, Inaba K, Akizawa F, Matsumoto N, Shidara M.
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都国際会議場 (京都)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Neuronal activity in the monkey orbitofrontal cortex related to reward value processing during a decision-making schedule task.

    • Author(s)
      Setogawa T, Mizuhiki T, Akizawa F, Matsumoto N, Shidara M.
    • Organizer
      43rd Annual meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego Convension Center, San Diego, CA, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Single neuronal activity in the rhesus monkey orbitofrontal cortex related to reward value processing during the decision-making schedule task.

    • Author(s)
      Setogawa T, Mizuhiki T, Akizawa F, Kuboki R, Matsumoto N, Shidara M.
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島大学 (鹿児島)
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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