Brain information processing mechanism of reward-value coding during decision-making

• Project/Area Number: 25282246
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Basic / Social brain science
• Research Institution: University of Tsukuba
• Principal Investigator: Shidara Munetaka 筑波大学, 医学医療系, 教授 (10357189)
• Co-Investigator(Kenkyū-buntansha): MATSUMOTO NARIHISA 国立研究開発法人産業技術総合研究所, 人間情報研究部門, 主任研究員 (00392663) ; HIGO NORIYUKI 国立研究開発法人産業技術総合研究所, 人間情報研究部門, 主任研究員 (80357839) ; MATSUDA KEIJI 国立研究開発法人産業技術総合研究所, 人間情報研究部門, 主任研究員 (50358024)
• Co-Investigator(Renkei-kenkyūsha): SUGASE YASUKO 国立研究開発法人産業技術総合研究所, 人間情報研究部門, 主任研究員 (40357257) ; MIZUHIKI TAKASHI 筑波大学, 医学医療系, 助教 (60463824)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000); Fiscal Year 2015: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000); Fiscal Year 2014: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000); Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
• Keywords: 報酬価値 / 行動決定 / 労働負荷 / 労働割引モデル / 眼窩前頭皮質 / 単一ニューロン記録 / アカゲザル / ムシモル / 単一ニューロン活動 / 時間割引モデル / 単一ニューロン / 報酬系 / 自己選択効果

Outline of Final Research Achievements

We investigated information processing mechanism of reward value coding during decision-making by using the task of choosing one of two alternatives that have different work load and reward amount. Neuronal responses in the orbitofrontal cortex had correlation with the difference or summation of values of the two alternatives. Bilateral injection of muscimol into the recording areas induced increase in error rates and choice reaction times during decision-making.

Research Products

• [Int'l Joint Research] National Institute of Mental Health(米国)
• [Journal Article] Small effect of upcoming reward outcomes on visual cue-related neuronal activity in macaque area TE during conditional association (2014)
  • Author(s): K.Ohyama, Y.Sugase-Miyamoto, N.Matsumoto, C.Sato, M.Shidara
  • Journal Title: Neuroscience Research Volume: 88 Pages: 28-38
  • DOI: 10.1016/j.neures.2014.08.004
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Reward expectancy signals in monkey anterior cingulate cortex and its relation to reinforcement learning. (2014)
  • Author(s): Shidara M
  • Journal Title: Alcohol Alcohol Volume: 49 suppl.1 Issue: suppl 1 Pages: i30-i30
  • DOI: 10.1093/alcalc/agu052.148
• [Journal Article] Self-choice enhances value in reward-seeking in primates (2014)
  • Author(s): Tsuyoshi Setogawa, Takashi Mizuhiki, Narihisa Matsumoto, Fumika Akizawa, Munetaka Shidara
  • Journal Title: Neuroscience Research Volume: - Pages: 45-54
  • DOI: 10.1016/j.neures.2014.01.004
  • Peer Reviewed
• [Journal Article] 動機付け、報酬期待と腹側線条体（側坐核） (2014)
  • Author(s): 設楽宗孝
  • Journal Title: Clinical Neuroscience Volume: 32 Pages: 40-43
• [Presentation] Reward value coding by single neuron in the monkey orbitofrontal cortex during decision-making. (2016)
  • Author(s): Setogawa T, Mizuhiki T, Akizawa F, Kuboki R, Richmond BJ, Matsumoto N, Shidara M
  • Organizer: 第93回日本生理学会大会
  • Place of Presentation: 札幌コンベンションセンター （北海道札幌市）
  • Year and Date: 2016-03-21
• [Presentation] サル眼窩前頭皮質における報酬価値表現 (2015)
  • Author(s): Setogawa T, Mizuhiki T, Akizawa F, Kuboki R, Matsumoto N, Shidara M
  • Organizer: 包括脳冬のシンポジウム
  • Place of Presentation: 一橋大学一橋講堂 学術総合センター（東京都千代田区）
  • Year and Date: 2015-12-17
• [Presentation] Representation of reward value by single unit in the monkey orbitofrontal cortex during decision-making. (2015)
  • Author(s): Setogawa T, Mizuhiki T, Akizawa F, Kuboki R, Richmond BJ, Matsumoto N, Shidara M
  • Organizer: 45th Annual meeting of the Society for Neuroscience
  • Place of Presentation: Chicago Convention Center, Chicago, USA
  • Year and Date: 2015-10-17
  • Int'l Joint Research
• [Presentation] Representation of reward value by single neuron in the monkey orbitofrontal cortex during decision-making. (2015)
  • Author(s): Setogawa T, Mizuhiki T, Akizawa F, Kuboki R, Matsumoto N, Shidara M
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2015-07-29
• [Presentation] Neuronal activity of dorsal raphe nucleus during reward schedule. (2015)
  • Author(s): Shidara M
  • Organizer: 第92回日本生理学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-21 – 2015-03-23
• [Presentation] Neuronal activity in the monkey orbitofrontal cortex related to reward value processing during decision-making (2015)
  • Author(s): Setogawa T, Mizuhiki T, Akizawa F, Kuboki R, Matsumoto N, Shidara M
  • Organizer: 第92回日本生理学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-21 – 2015-03-23
• [Presentation] Single unit activity in the monkey orbitofrontal cortex related to reward value processing during decision-making (2014)
  • Author(s): Setogawa T, Mizuhiki T, Akizawa F, Kuboki R, Matsumoto N, Shidara M.
  • Organizer: International Symposium “Vision, Memory, Thought: how cognition emerges from neural network”
  • Place of Presentation: 東京
  • Year and Date: 2014-12-06 – 2014-12-07
• [Presentation] Single neuronal activity in the monkey orbitofrontal cortex related to reward value processing during decision-making. (2014)
  • Author(s): Setogawa T, Mizuhiki T, Akizawa F, Kuboki R, Matsumoto N, Shidara M
  • Organizer: 44th Annual meeting of the Society for Neuroscience
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Reward expectancy signals in monkey anterior cingulate cortex and its relation to reinforcement learning (2014)
  • Author(s): Shidara M
  • Organizer: 16th International Society of Addiction and Medicine Annual Meeting
  • Place of Presentation: 横浜
  • Year and Date: 2014-10-02 – 2014-10-06
  • Invited
• [Presentation] Single unit activity in the monkey orbitofrontal cortex related to reward value processing during decision-making (2014)
  • Author(s): Setogawa T, Mizuhiki T, Akizawa F, Kuboki R, Matsumoto N, Shidara M
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] Single neuronal activity in the monkey orbitofrontal cortex related to reward value processing during the decision-making schedule task.
  • Author(s): Setogawa T, Mizuhiki T, Inaba K, Akizawa F, Matsumoto N, Shidara M.
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都国際会議場 （京都）
• [Presentation] Neuronal activity in the monkey orbitofrontal cortex related to reward value processing during a decision-making schedule task.
  • Author(s): Setogawa T, Mizuhiki T, Akizawa F, Matsumoto N, Shidara M.
  • Organizer: 43rd Annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego Convension Center, San Diego, CA, USA
• [Presentation] Single neuronal activity in the rhesus monkey orbitofrontal cortex related to reward value processing during the decision-making schedule task.
  • Author(s): Setogawa T, Mizuhiki T, Akizawa F, Kuboki R, Matsumoto N, Shidara M.
  • Organizer: 第91回日本生理学会大会
  • Place of Presentation: 鹿児島大学 （鹿児島）