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Re-evaluation of the basal ganglia network in rat

Research Project

Project/Area Number 25282247
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Basic / Social brain science
Research InstitutionDoshisha University

Principal Investigator

Fujiyama Fumino  同志社大学, 脳科学研究科, 教授 (20244022)

Co-Investigator(Kenkyū-buntansha) KARUBE Fuyuki  同志社大学, 研究開発推進機構, 准教授 (60312279)
TAKAHASHI Susumu  同志社大学, 研究開発推進機構, 准教授 (20510960)
松田 和郎  京都大学, 健康長寿社会の総合医療開発ユニット, 特任講師 (80444446)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2013: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Keywords視床 / 線条体 / 基底核 / 大脳基底核 / パーキンソン病 / シングルニューロン
Outline of Final Research Achievements

A fundamental organizing principle of the striatum is the striosome/matrix system that is defined by inputs/outputs and neurochemical markers. The thalamostriatal projection is highly heterogeneous originating in many subnuclei of the thalamus including the midline (ML) and intralaminar (IL) nuclei. In the striatum, ML neurons preferentially innervated striosomes, whereas parafascicular neurons preferentially innervated the matrix. Almost all single thalamostriatal neurons favoring striosome or matrix compartments also innervated the cerebral cortical area that supplied cortical input to the same striatal compartment. We thus revealed that thalamostriatal projections are highly organized 1) by the similarity in morphological characteristics and 2) their preference for the striatal compartments and cortical areas.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (44 results)

All 2016 2015 2014 2013 Other

All Journal Article (13 results) (of which Peer Reviewed: 8 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (24 results) (of which Invited: 13 results) Book (4 results) Remarks (3 results)

  • [Journal Article] Quantitative Analyses of the Projection of individual Neurons from the Midline Thalamic Nuclei to the Striosome and Matrix Compartments of the Rat Striatum.2016

    • Author(s)
      Unzai, T., Kuramoto, E., Kaneko, T., Fujiyama, F.
    • Journal Title

      Cerebral Cortex

      Volume: in press Pages: 1-1

    • DOI

      10.1093/cercor/bhv295

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Neuronal circuits and physiological roles of the basal ganglia in terms of transmitters, receptors and related disorders. The Journal of Physiological Sciences.2016

    • Author(s)
      Yamada K, Takahashi S, Karube F, Fujiyama F, Kobayashi K, Nishi A, Momiyama T
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 0 Issue: 6 Pages: 1-12

    • DOI

      10.1007/s12576-016-0445-4

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A single-neuron tracing study of arkypallidal and prototypic neurons in healthy rats2015

    • Author(s)
      Fujiyama F, Nakano T, Matsuda W, Furuta T, Udagawa J, Kaneko T
    • Journal Title

      Brain Struct. Funct.

      Volume: published online Issue: 9 Pages: 1-8

    • DOI

      10.1007/s00429-015-1152-2

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Morphological elucidation of basal ganglia circuits contributing reward prediction2015

    • Author(s)
      2.Fujiyama, S., Takahashi, S., and Karube, F.
    • Journal Title

      Frontiers in Neuroscience

      Volume: 9:6 Pages: 1-8

    • DOI

      10.3389/fnins.2015.00006

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 大脳基底核を巡る伝導路2015

    • Author(s)
      高橋晋、藤山文乃
    • Journal Title

      Clinical Neuroscience

      Volume: 33 Pages: 767-771

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
  • [Journal Article] 神経伝達物質2015

    • Author(s)
      藤山文乃
    • Journal Title

      脳神経外科医が知っておくべきニューロサイエンスの知識

      Volume: 1 Pages: 1-1

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
  • [Journal Article] Singular localization of sodium channel β4 subunit in unmyelinated fibres and its role in the striatum.2015

    • Author(s)
      Miyazaki H, Oyama F, Inoue R, Aosaki T, Abe T, Kiyonari H, Kino Y, Kurosawa M, Shimizu J, Ogiwara I, Yamakawa K, Koshimizu Y, Fujiyama F, Kaneko T, Shimizu H, Nagatomo K, Yamada K, Shimogori T, Hattori N, Miura M, Nukina N.
    • Journal Title

      Nature Communications

      Volume: 2 Pages: 5525-5525

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Analysis of basal ganglia network by single-neuron-tracing method.2014

    • Author(s)
      Fujiyama F
    • Journal Title

      rontiers in Parkinson Disease.

      Volume: 1 Pages: 1-1

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 大脳基底核回路の形態学的解析2014

    • Author(s)
      藤山文乃
    • Journal Title

      神経回路学会誌

      Volume: 21 Pages: 132-135

    • NAID

      130004713865

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 大脳基底核の神経回路2014

    • Author(s)
      藤山文乃
    • Journal Title

      Clinical Neuroscience

      Volume: 32 Pages: 30-32

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Long-lasting single-neuron labeling by in vivo electrop oration without microscopic guidance2013

    • Author(s)
      Kei Oyama, Shinya Ohara, Sho Satoa, Fuyuki Karube, Fumino Fujiyama, Yoshikazu Isomura, Hajime Mushiake, Toshio Iijima, Ken-Ichiro Tsutsui
    • Journal Title

      Journal of Neuroscience Methods

      Volume: 218 Issue: 2 Pages: 139-147

    • DOI

      10.1016/j.jneumeth.2013.06.004

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A quantitative analy- sis of axon bouton distribution of subthal- amic nucleus neurons in the rat by single neuron visualization with a viral vector.2013

    • Author(s)
      Koshimizu Y, Fujiyama F, Nakamura KC, Furuta T, Kaneko T
    • Journal Title

      The Journal of Comparative Neurology

      Volume: vol. 521(no. 9) Issue: 9 Pages: 2125-2146

    • DOI

      10.1002/cne.23277

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell type-specific inhibitory inputs to dendritic and somatic compartments of parvalbumin-expressing neocortical interneuron.2013

    • Author(s)
      Hioki H, Okamoto S, Konno M, Kameda H, Sohn J, Kuramoto E, Fujiyama F, Kaneko T
    • Journal Title

      The Journal of Neuroscience

      Volume: vol. 33 (no. 2) Issue: 2 Pages: 544-555

    • DOI

      10.1523/jneurosci.2255-12.2013

    • NAID

      120005300466

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Quantitative Analyses of the Thalamic Projections to the Striosome and Matrix Compartments of the Rat Striatum2016

    • Author(s)
      藤山文乃
    • Organizer
      121回日本解剖学会 総会・全国学術集会
    • Place of Presentation
      福島県立医大(福島)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] パーキンソン病の症状を 大脳基底核回路から考察する2016

    • Author(s)
      藤山文乃
    • Organizer
      パーキンソン病の基礎と臨床
    • Place of Presentation
      ヒルトン大阪(大阪)
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] パーキンソン病と機能神経外科生理学的知見再考2016

    • Author(s)
      藤山文乃
    • Organizer
      第55回日本定位・機能神経外科学会
    • Place of Presentation
      江陽グランドホテル(仙台)
    • Year and Date
      2016-01-22
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 行動システム脳科学の新展開2015

    • Author(s)
      藤山文乃
    • Organizer
      平成27年度生理研研究会
    • Place of Presentation
      生理研(愛知)
    • Year and Date
      2015-12-04
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 視床線条体投射とストリオソーム・マトリックス構造2015

    • Author(s)
      藤山文乃
    • Organizer
      第91回日本解剖学会近畿支部学術集会
    • Place of Presentation
      京都工芸繊維大学(京都)
    • Year and Date
      2015-11-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 大脳基底核ネットワークの解析2015

    • Author(s)
      藤山文乃
    • Organizer
      第45回日本臨床神経生理学会学術大会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 大脳基底核を形態学的に再検証する2015

    • Author(s)
      藤山文乃
    • Organizer
      第40回関東機能的脳外科カンファランス
    • Place of Presentation
      研究社英語セタービル(東京)
    • Year and Date
      2015-08-29
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 大脳基底核を形態学的に再検証する2015

    • Author(s)
      藤山文乃
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場(神戸)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Single neuron analysis of the Basal Ganglia2015

    • Author(s)
      藤山文乃
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場(神戸)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 大脳基底核の真の姿を探して2015

    • Author(s)
      藤山文乃
    • Organizer
      第3回さいたまパーキンソン病カンファレンス
    • Place of Presentation
      ラフレさいたま(さいたま市)
    • Year and Date
      2015-04-07
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 大脳基底核の真の姿を求めて2015

    • Author(s)
      藤山文乃.
    • Organizer
      第3回さいたまパーキンソン病カンファレンス
    • Place of Presentation
      さいたま
    • Year and Date
      2015-04-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 大脳基底核機能領域の形態学的同定2015

    • Author(s)
      藤山文乃.
    • Organizer
      第120回日本解剖学会総会・全国学術集会・第92回日本生理学会大会合同大会シンポジウム
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-20 – 2015-03-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] よくわかる大脳基底核の解剖と作用薬2014

    • Author(s)
      藤山文乃.
    • Organizer
      第8回パーキンソン病・運動障害疾患コングレス
    • Place of Presentation
      京都
    • Year and Date
      2014-10-02
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Toward a novel closed-loop deep brain stimulation for ameliorating the Parkinson’s disease.2014

    • Author(s)
      Takahashi S, Unzai T, Kobayashi K, Karube F, Fujiyama F.
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] The topography of striatopallidal projections and calbindin immunoreactive subdivisions.2014

    • Author(s)
      Mizutani K, Karube F, Oh YM, Nakano Y, Fujiyama F.
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Immunohistochemical compartments of the globus pallidus and their projection patterns.2014

    • Author(s)
      Oh YM, Mizutani K, Nakano Y, Unzai T, Karube F, Fujiyama F.
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Topological projections of direct and indirect pathway neurons in the neostriatum to the GPe.2014

    • Author(s)
      Okamoto S, Hioki H, Sohn J, Fujiyama F, Kaneko T.
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 報酬予測をつくる大脳基底核回路の形態学的解明2014

    • Author(s)
      藤山文乃.
    • Organizer
      第29回日本大脳基底核研究会
    • Place of Presentation
      青森
    • Year and Date
      2014-08-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Innervation of pallidal neurons by a striatal direct and indirect neurons in the rat.2013

    • Author(s)
      Mizutani K, Karube F, Takahashi S, Unzai T, Fujiyama F.
    • Organizer
      The 36th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Annual Research Report
  • [Presentation] Neural connection pattern in the rat basal ganglia, with relation to cortico-subthalamic pathway.2013

    • Author(s)
      Karube F, Fujiyama F
    • Organizer
      The 36th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Annual Research Report
  • [Presentation] Quantitative analysis of single cell projection from midline and intralaminar thalamic nuclei to striosome and matrix compartments of rat striatum.2013

    • Author(s)
      Unzai T, Kuramoto E, Kaneko T, Fujiyama F
    • Organizer
      The 36th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Annual Research Report
  • [Presentation] Regional Difference in Network between the Striatum and Globus Pallidus.2013

    • Author(s)
      Fujiyama F, Nakano T, Matsuda W, Oh YM, Mizutani K, Furuta T, Karube F, Takahashi S, Unzai T, Udagawa J, Kaneko T
    • Organizer
      The 36th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Annual Research Report
  • [Presentation] Axonal arborization of midbrain non-dopaminergic neurons: single-cell study.2013

    • Author(s)
      Matsuda W, Furuta T, Kuramoto E, Hioki H, Fujiyama F, Kaneko T
    • Organizer
      The 36th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Excitatory and Inhibitory Inputs to Parvalbumin-Expressing Interneurons in the Mouse Primary Motor Cortex.2013

    • Author(s)
      Hioki H, Sohn J, Kuramoto E, Okamoto S, Wang T, Kameda H, Fujiyama F, Kaneko T
    • Organizer
      The 36th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Annual Research Report
  • [Book] 脳神経外科医が知っておくべきニューロサイエンスの知識2015

    • Author(s)
      藤山文乃、共著者多数、編集:三國信啓、深谷親
    • Total Pages
      226
    • Publisher
      文光堂
    • Related Report
      2015 Annual Research Report
  • [Book] Clinical Neuroscience2014

    • Author(s)
      藤山文乃
    • Total Pages
      3
    • Publisher
      中外医学社
    • Related Report
      2013 Annual Research Report
  • [Book] 生体の科学2013

    • Author(s)
      藤山文乃
    • Total Pages
      5
    • Publisher
      医学書院
    • Related Report
      2013 Annual Research Report
  • [Book] 脳神経科学イラストレイテッド2013

    • Author(s)
      藤山文乃
    • Total Pages
      6
    • Publisher
      羊土社
    • Related Report
      2013 Annual Research Report
  • [Remarks] 神経回路形態部門 藤山文乃研究室 藤山 文乃

    • URL

      http://ncircuit.doshisha.ac.jp

    • Related Report
      2015 Annual Research Report
  • [Remarks] 同志社大学脳科学研究科神経回路形態部門藤山文乃研究室

    • URL

      http://ncircuit.doshisha.ac.jp/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 同志社大学脳科学研究科神経回路形態部門

    • URL

      http://brainscience.doshisha.ac.jp/introduction/sys/nc.html

    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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