Re-evaluation of the basal ganglia network in rat
Project/Area Number |
25282247
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Basic / Social brain science
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Research Institution | Doshisha University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
KARUBE Fuyuki 同志社大学, 研究開発推進機構, 准教授 (60312279)
TAKAHASHI Susumu 同志社大学, 研究開発推進機構, 准教授 (20510960)
松田 和郎 京都大学, 健康長寿社会の総合医療開発ユニット, 特任講師 (80444446)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2013: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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Keywords | 視床 / 線条体 / 基底核 / 大脳基底核 / パーキンソン病 / シングルニューロン |
Outline of Final Research Achievements |
A fundamental organizing principle of the striatum is the striosome/matrix system that is defined by inputs/outputs and neurochemical markers. The thalamostriatal projection is highly heterogeneous originating in many subnuclei of the thalamus including the midline (ML) and intralaminar (IL) nuclei. In the striatum, ML neurons preferentially innervated striosomes, whereas parafascicular neurons preferentially innervated the matrix. Almost all single thalamostriatal neurons favoring striosome or matrix compartments also innervated the cerebral cortical area that supplied cortical input to the same striatal compartment. We thus revealed that thalamostriatal projections are highly organized 1) by the similarity in morphological characteristics and 2) their preference for the striatal compartments and cortical areas.
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Report
(4 results)
Research Products
(44 results)
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[Journal Article] Singular localization of sodium channel β4 subunit in unmyelinated fibres and its role in the striatum.2015
Author(s)
Miyazaki H, Oyama F, Inoue R, Aosaki T, Abe T, Kiyonari H, Kino Y, Kurosawa M, Shimizu J, Ogiwara I, Yamakawa K, Koshimizu Y, Fujiyama F, Kaneko T, Shimizu H, Nagatomo K, Yamada K, Shimogori T, Hattori N, Miura M, Nukina N.
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Journal Title
Nature Communications
Volume: 2
Pages: 5525-5525
Related Report
Peer Reviewed / Open Access
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[Presentation] 大脳基底核の真の姿を探して2015
Author(s)
藤山文乃
Organizer
第3回さいたまパーキンソン病カンファレンス
Place of Presentation
ラフレさいたま(さいたま市)
Year and Date
2015-04-07
Related Report
Invited
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[Presentation] Regional Difference in Network between the Striatum and Globus Pallidus.2013
Author(s)
Fujiyama F, Nakano T, Matsuda W, Oh YM, Mizutani K, Furuta T, Karube F, Takahashi S, Unzai T, Udagawa J, Kaneko T
Organizer
The 36th Annual Meeting of the Japan Neuroscience Society
Place of Presentation
Kyoto
Related Report
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