| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2017: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
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| Outline of Final Research Achievements |
Psychiatric symptoms of schizophrenia suggest alterations of cerebral neurons. However, the physical basis of schizophrenia has not been delineated. In this study we analyzed tissue structures of the anterior cingulate cortex of schizophrenia and control cases with nanotomography at SPring-8 and at Advanced Photon Source of Argonne National Lab. Tissue constituents visualized in the 3D images were traced to build Cartesian coordinate models of neurons. Neurite geometries were then evaluated by calculating the curvature and torsion from the Cartesian coordinates. The obtained results indicated that neuronal structures are different between individuals, and those differences become extraordinary in schizophrenia. The anterior cingulate cortex is considered responsible for cognitive functions including decision making. The geometrical alteration identified in this study should reflect psychiatric symptoms of schizophrenia.
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