Capsule like-assembly of magnetic nanoparticles enabling the drug release by radio wave irradiation
| Project/Area Number |
25286001
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nanostructural chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
Niikura Kenichi 北海道大学, 電子科学研究所, 准教授 (40360896)
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| Co-Investigator(Renkei-kenkyūsha) |
NINOMIYA Takafumi 札幌医科大学, 医学部, 准教授 (80156140)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Keywords | 自己組織化 / ナノ粒子 / 刺激応答性 / 階層構造 / 磁性粒子 / 金ナノ粒子 / 金属ナノ粒子 / 自己集合 |
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| Outline of Final Research Achievements |
In this research, to develop stimuli-responsive drug delivery carriers, we explored surface ligand molecules that can induce the self-assembly of metallic nanoparticles, such as magnetic or gold nanoparticles in solutions. It was found that surface modification with a ligand molecule possessing a fluorinated oligoethylene glycol (SFL) induced spherical self-assembly of magnetic nanoparticles as well as gold nanoparticles. Interestingly, the glucose-terminated SFL molecules enabled the formation of size-segregated structures when used with a mixture of gold nanoparticles of two different diameters. Gold nanoparticles showing thermal responsiveness were also successfully created.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Yolk/Shell Assembly of Gold Nanoparticles by Size Segregation in Solution2016
Author(s)
J. Wei, K. Niikura, T. Higuchi, T. Kimura, H. Mitomo, H. Jinnai, Y. Joti, Y. Bessho, Y. Nishino, Y. Matsuo, and K. Ijiro
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Journal Title
J. Am. Chem. Soc.
Volume: 138(10)
Issue: 10
Pages: 3274-3277
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Amphiphilic Gold Nanoparticles Displaying Flexible Bifurcated Ligands as a Carrier for siRNA Delivery into the Cell Cytosol2014
Author(s)
Kenichi Niikura, Kenya Kobayashi, Chie Takeuchi, Naoki Fujitani, Shuko Takahara, Takafumi Ninomiya, Kyoji Hagiwara, Hideyuki Mitomo, Yoshihiro Ito, Yoshihito Osada, and Kuniharu Ijiro,
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Journal Title
ACS Appl. Mater. Interfaces
Volume: 6
Issue: 24
Pages: 22146-22154
DOI
Related Report
Peer Reviewed
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