| Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Outline of Final Research Achievements |
In this research, to develop stimuli-responsive drug delivery carriers, we explored surface ligand molecules that can induce the self-assembly of metallic nanoparticles, such as magnetic or gold nanoparticles in solutions. It was found that surface modification with a ligand molecule possessing a fluorinated oligoethylene glycol (SFL) induced spherical self-assembly of magnetic nanoparticles as well as gold nanoparticles. Interestingly, the glucose-terminated SFL molecules enabled the formation of size-segregated structures when used with a mixture of gold nanoparticles of two different diameters. Gold nanoparticles showing thermal responsiveness were also successfully created.
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