| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2013: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Outline of Final Research Achievements |
We developed a promising method to control biomolecular reactions with the use of optical force originating from plasmonically-induced strong gradient electric field in the vicinity of metallic nanostrucutures. Optical forces generated between two metallic nanostructures were quantitatively and qualitatively characterized by our advanced atomic force microscopy (AFM) with high force sensitivity. The optical forces were significantly dependent on the incident laser wavelength, and size and shape of the metallic nanostructures. The strongly-enhanced optical forces enabled us to increase probability of biomolecular recognition by around 10 %. Finally, as an alternative to the plasmonic structures, dielectric nanostructures with high-refractive index were developed in order to suppress laser-induced heat generation toward non-invasive biomolecular analysis.
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