Fabrication of ship-in-a-bottle biochips by hybrid femtosecond laser processing
| Project/Area Number |
25286038
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nano/Microsystems
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
SUGIOKA Koji 国立研究開発法人理化学研究所, 光量子工学研究領域, ユニットリーダー (70187649)
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| Co-Investigator(Kenkyū-buntansha) |
WU Dong 国立研究開発法人理化学研究所, 光量子工学研究領域, 国際特別研究員 (50618775)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWANO Hiroyuki 国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員 (10332256)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
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| Keywords | 先端機能デバイス / マイクロナノデバイス / レーザー加工 / ナノマイクロファブリケーション / バイオチップ / ナノマイクロファブリケー ション / フェムト秒レーザー / ３次元加工 / ボトルシップ型加工 / フェムト秒レーザー加工 |
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| Outline of Final Research Achievements |
To fabricate a new type of biochips possessing high functionalities referred to as ship-in-a-bottle biochips, we developed hybrid femtosecond laser processing, in which three-dimensional (3D) glass micromachining and two-photon micro/nano polymerization were successively carried out. The developed technique allowed us to integrate multifunctional components into the 3D glass microfluidic structures for filtering microparticles and efficiently mixing two kinds of fluids in the microchannel at the same time. Furthermore, integration of a microlens array combined with center-pass units realized the ship-in-a-bottle biochip enabling parallel detection and counting of biological cells with the 100% success rate.
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Report
(4 results)
Research Products
(70 results)
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[Journal Article] High efficiency integration of three-dimensional functional microdevices inside a microfluidic chip by using femtosecond laser multifoci parallel microfabrication2016
Author(s)
B. Xu, W. Du, J. Li, Y. Hu, L. Yang, C. Zhang, G. Li, Z. Lao, J. Ni, J. Chu, D. Wu, S. Liu, and K. Sugioka
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Journal Title
Sci. Rep.
Volume: 6
Issue: 1
Pages: 19989-19989
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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