| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
|
|---|
| Outline of Final Research Achievements |
Magnetic nanoparticles (NPs) encapsulated in amorphous SiO2 were prepared using our original wet chemical method. We got various magnetic clusters such as iron oxides, hydroxides and ferrites. These magnetic particles were further functionalized for biomedical applications . We have introduced the NPs into the cells, and localization by external field in tissue was also confirmed. Then cancer cell selective NPs were developed by conjugating with folic acid. Based on this technique, we proposed magnetic hyperthermia treatment.
In order to realize magnetic hyperthermia treatment, DC magnetization and AC magnetic susceptibilities were measured by SQUID magnetometer. Then, optimization of magnetic parameters for nanoparticles was performed. Furthermore, in vitro experiments to study the hyperthermia effects of these particles on cancerous cells were carried out. Drastic effect of magnetic hyperthermia was observed.
|
