Magnetic hyperthermia system and preparation of superparamagnetic nanoparticles following Neel relazation
Project/Area Number |
25286041
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Applied materials
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Research Institution | Yokohama National University |
Principal Investigator |
Ichiyanagi Yuko 横浜国立大学, 大学院工学研究院, 准教授 (90240762)
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Co-Investigator(Kenkyū-buntansha) |
千本松 孝明 埼玉医科大学, 医学部, 准教授 (70216563)
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Project Period (FY) |
2013-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
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Keywords | 微粒子 / 磁化率 / ナノ医療 / ハイパーサーミア / セラノスティクス / 磁性 / ナノ材料 / 物性実験 / 結晶工学 / 交流磁化率 / ナノテクノロジー / がん温熱療法 / 局所構造 / DDS / 磁性体 / 磁化測定 |
Outline of Final Research Achievements |
Magnetic nanoparticles (NPs) encapsulated in amorphous SiO2 were prepared using our original wet chemical method. We got various magnetic clusters such as iron oxides, hydroxides and ferrites. These magnetic particles were further functionalized for biomedical applications . We have introduced the NPs into the cells, and localization by external field in tissue was also confirmed. Then cancer cell selective NPs were developed by conjugating with folic acid. Based on this technique, we proposed magnetic hyperthermia treatment. In order to realize magnetic hyperthermia treatment, DC magnetization and AC magnetic susceptibilities were measured by SQUID magnetometer. Then, optimization of magnetic parameters for nanoparticles was performed. Furthermore, in vitro experiments to study the hyperthermia effects of these particles on cancerous cells were carried out. Drastic effect of magnetic hyperthermia was observed.
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Report
(5 results)
Research Products
(89 results)
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[Journal Article] Effect of Chelate Ring Size in Iron(II) Isothiocyanato Complexes with Tetradentate Tripyridyl-alkylamine Ligands on Spin Crossover Properties2016
Author(s)
Michael Leibold, Sandra Kisslinger, Frank W. Heinemann, Frank Hampel, Yuko Ichiyanagi. Michael Kein, Patrick Homenya, Franz Renz, Hans Toftlund, Georg Brehm, Siegfried Schneider, Markus Reiher, and Siegfried Schindler
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Journal Title
Z. Anorg. Allg. Chem.
Volume: 642
Pages: 85-94
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] AC Magnetic Susceptibility and Heat Dissipation by Mn1-xZnxFe2O4 Nanoparticles for Hyperthermia Treatment2015
Author(s)
Takaya Kondo, Kazumasa Mori, Masaya Hachisu, Takahiro Yamazaki, Daiki Okamoto, Masatoshi Watanabe, Kohsuke Gonda, Hiroshi Tada, Yoh Hamada, Mayumi Takano, Noriaki Ohuchi, and Yuko Ichiyanagi
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Journal Title
J. Appl. Phys.
Volume: 117
Issue: 17
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] AC Magnetic Susceptibility and Heat Dissipation by Mn1-xZnxFe2O4 Nanoparticles for Hyperthermia Treatment2015
Author(s)
Takaya Kondo, Kazumasa Mori, Masaya Hachisu, Takahiro Yamazaki, Daiki Okamoto, Masatoshi Watanabe, Kohsuke Gonda, Hiroshi Tada, Yoh Hamada, Mayumi Takano, Noriaki Ohuchi, and Yuko Ichiyanagi
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Journal Title
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Mn-Zn ferrite nanoparticles as an agent for hyperthermia treatment, MRI and CT imaging2015
Author(s)
T. Ishikawa, J. Ichikawa, K. Hyodo, S. Morimoto, T. Yamazaki, Y. Hosokai, A. Usui, Y. Machida, S. Saito, M. Takano, M. Tokunaga, K. Gonda, Y. Ichiyanagi
Organizer
9th International Symposium on Nanomedicine
Place of Presentation
三重
Year and Date
2015-12-10
Related Report
Int'l Joint Research
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