| Project/Area Number |
25286062
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Optical engineering, Photon science
|
|---|
| Research Institution | Muroran Institute of Technology |
|---|
Principal Investigator |
KANO Hiroshi 室蘭工業大学, 工学(系)研究科(研究院), 准教授 (80322874)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HASEGAWA Hideki 国立感染症研究所, 感染病理部, 部長 (30301790)
MORIGAKI Kenichi 神戸大学, 遺伝子実験センター, 准教授 (10358179)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2013: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
|
|---|
| Keywords | 表面プラズモン / 屈折率測定 / インフルエンザウイルス / サブタイプ判定 / 顕微屈折率計測 / 基板表面化学修飾 / ウイルス検出 |
|---|
| Outline of Final Research Achievements |
Development of a method for quick subtype determination of influenza viruses is important because infectious and pathogenic properties of viruses are different. In this research, we proposed a method in which refractive index change due to antigen-antibody reaction between target viruses with certain subtype and monoclonal antibodies fixed in a micro-channel on a sensing substrate. To realize this concept, we successfully improved stability and sensitivity of a measurement system for virus detection, confirmed a measurement principle for faster data acquisition, and developed a technique to modify chemical property of a substrate surface to locate certain antibodies in a controlled region.
|
