| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
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| Outline of Final Research Achievements |
Construction of 3D structures by multi cellular system, such as blood vessel, clusters of air-exchanging sacks, produces specific functions. To construct 3D structures, cells should move collectively. However, the mechanism of cellular collective movement is not unclear yet. This project is aimed to elucidate mechanism of cellular collective movement by developing cell tracking system, 2D and 3D cellular traction force measurement, cell junction protein-knockout cell lines. In addition, we simulated multi cellular collective movement by making motion equation for cells. Combination of cell tracking system and established knockout cell lines showed that collective movement requires a cell-cell junction protein. The results of computer simulation indicated that important factor is not only cell-cell contact but also cellular modulate elasticity. These findings may be useful to design an intended 3D structure in the field of tissue regeneration.
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