Development of asymmetric generation and amplification phenomenon from achiral substance

• Project/Area Number: 25288017
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Organic chemistry
• Research Institution: Chiba University
• Principal Investigator: Sakamoto Masami 千葉大学, 工学(系)研究科(研究院), 教授 (00178576)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000); Fiscal Year 2015: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2014: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2013: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
• Keywords: 不斉合成 / 絶対不斉合成 / 優先晶出 / 動的結晶化 / アミノ酸 / 光化学 / 有機結晶 / コングロメレート / 有機結晶化学 / 光学分割

Outline of Final Research Achievements

Development of a new absolute asymmetric synthesis via chiral amplification was studied, which involved a chemical reaction generating chiral center from absolutely achiral starting substrates and dynamic preferential crystallization. The proposed method of chiral amplification was performed on the basis of next requirements. (1) Stereoselective reaction generating chiral center from achiral starting materials under absolutely achiral conditions. (2) Fast racemization of generated chiral center among preferential crystallization. New methodology of an absolute asymmetric synthesis was provided for a synthesis of amino acid derivatives involving reversible Michael addition of amines to enones and valuable heterocycles via many types of reversible reactions followed by dynamic preferential crystallization.

Research Products

• [Journal Article] Chiral N-(tert-butyl)-N-methylaniline type ligands: Synthesis and application to palladium-catalyzed asymmetric allylic alkylation (2015)
  • Author(s): Takashi Mino, Minato Asakawa, Yamato Shima, Haruka Yamada, Fumitoshi Yagishita, Masami Sakamoto
  • Journal Title: Tetrahedron Volume: 71 Issue: 35 Pages: 5985-5993
  • DOI: 10.1016/j.tet.2015.01.027
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] BINOL-Al Catalysed Asymmetric Cyclization and Amplification: Preparation of Optically Active Menthol Analogs (2015)
  • Author(s): Hisanori Itoh, Hironori Maeda, Shinya Yamada, Yoji Hori, Takashi Mino, Masami Sakamoto
  • Journal Title: Org. Biomol. Chem. Volume: 13 Issue: 20 Pages: 5817-5825
  • DOI: 10.1039/c5ob00433k
  • Peer Reviewed
• [Journal Article] A new class of C2 chiral photodimer ligands for catalytic enantioselective dietylzinc addition to arylaldehydes (2015)
  • Author(s): Yuki Ueda, Fumitoshi Yagishita, Hiroki Ishikawa, Yuki Kaji, Nozomi Baba, Yoshio Kasashima, Takashi Mino, Masami Sakamoto
  • Journal Title: Tetrahedron Volume: 71 Issue: 36 Pages: 6254-6258
  • DOI: 10.1016/j.tet.2015.06.084
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Reversible changes of axial chirality of naphthamide by photochemical and thermal reactions (2015)
  • Author(s): Nobuo Yasuike, Fumitoshi Yagishita, Kazushi Sunaoshi, Yasuhiro Hasegawa, Takashi Mino, Masami Sakamoto
  • Journal Title: Journal of Photochemistry and Photobiology A: Chemistry Volume: 2015 Pages: 1-5
  • DOI: 10.1016/j.jphotochem.2015.07.010
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] BICMAP-rhodium(I)-catalyzed asymmetric 1,4-addition of arylboronic acids to coumarins (2015)
  • Author(s): Takashi Mino, Kazuki Miura, Hiroyuki Taguchi, Kohei Watanabe, Masami Sakamoto
  • Journal Title: Tetrahedron: Asymm. Volume: 26 Issue: 18-19 Pages: 1065-1068
  • DOI: 10.1016/j.tetasy.2015.08.005
  • Peer Reviewed
• [Journal Article] Hydrazone-palladium catalyzed annulation of 1-allyl-2-bromobenzene derivatives with internal alkynes (2015)
  • Author(s): Watanabe, Kohei; Mino, Takashi; Hatta, Chikako; Ito, Shisei; Sakamoto, Masami
  • Journal Title: Org. Biomol. Chem. Volume: 13 Issue: 48 Pages: 11645-11650
  • DOI: 10.1039/c5ob01959a
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Indium-catalyzed amide allylation of N-carbonyl imides: formation of azaspiro-γ-lactones via ring opening-reclosure (2015)
  • Author(s): Sengoku, Tetsuya; Murata, Yusuke; Aso, Yuwa; Kawakami, Ai; Inuzuka, Toshiyasu; Sakamoto, Masami; Takahashi, Masaki; Yoda, Hidemi
  • Journal Title: Organic Letters Volume: 17 Pages: 5846-5849
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Deracemization of Quinolonecarboxamides by Dynamic Crystalline Salt Formation and Asymmetric Photoreaction Using the Frozen Chirality (2014)
  • Author(s): Fumitoshi Yagishita, Naoya Takagishi, Hiroki Ishikawa, Yoshio Kasashima, Takashi Mino, Masami Sakamoto
  • Journal Title: Eur. J. Org. Chem Volume: 2014 Pages: 6366-6370
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Diastereoselective Photodimerization Reactions of Chromone-2-carboxamides to Construct a C2-Chiral Scaffold (2014)
  • Author(s): Fumitoshi Yagishita, Nozomi Baba, Yuki Ueda, Satoshi Katabira, Yoshio Kasashima, Takashi Mino, Masami Sakamoto
  • Journal Title: Org. Biomol. Chem. Volume: 12 Issue: 47 Pages: 9644-9649
  • DOI: 10.1039/c4ob01827c
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Suzuki-Miyaura Coupling of Aryl Sulfonates with Arylboronic Acids Using a Morpholine-Pd(OAc)2 Catalyst System (2014)
  • Author(s): Taichi Abe, Takashi Mino, Kohei Watanabe, Fumitoshi Yagishita, Masami Sakamoto
  • Journal Title: Eur. J. Org. Chem. Volume: 2014 Issue: 18 Pages: 3909-3916
  • DOI: 10.1002/ejoc.201402120
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Palladium-catalyzed decarboxylative coupling of benzoic acid derivatives using hydrazone ligands (2014)
  • Author(s): Takashi Mino, Eri Yoshizawa, Kohei Watanabe, Taichi Abe, Kiminori Hirai, Masami Sakamoto
  • Journal Title: Tetrahedron Lett. Volume: 55 Issue: 20 Pages: 3184-3188
  • DOI: 10.1016/j.tetlet.2014.04.017
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Highly selective aluminium-catalysed intramolecular Prins reaction for L-menthol synthesis (2014)
  • Author(s): Hisanori Itoh, Hironori Maeda, Shinya Yamada, Yoji Hori, Takashi Mino, Masami Sakamoto
  • Journal Title: RSC Adv. Volume: 4 Issue: 106 Pages: 61619-61623
  • DOI: 10.1039/c4ra12470g
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Kinetic resolution of citronellal by chiral aluminum catalysts: L-menthol synthesis from citral (2014)
  • Author(s): Hisanori Itoh, Hironori Maeda, Shinya Yamada, Yoji Hori, Takashi Mino, Masami Sakamoto
  • Journal Title: Org. Chem. Front. Volume: 1 Issue: 9 Pages: 1107-1115
  • DOI: 10.1039/c4qo00222a
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Asymmetric Transformation by Dynamic Crystallization of Achiral Succinimides (2013)
  • Author(s): Shoko Hachiya, Yoshio Kasashima, Fumitoshi, Yagishita, Takashi Mino, Hyuma Masu, Masami Sakamoto
  • Journal Title: Chem. Commun Volume: 49 Issue: 42 Pages: 4776-4778
  • DOI: 10.1039/c3cc41678j
  • Peer Reviewed
• [Journal Article] Chiral Symmetry Breaking of Axially Chiral Nicotinamide by Crystallization from the Melt (2013)
  • Author(s): Fumitoshi Yagishita, Kazuma Okamoto, Norifumi Kamataki, Shota Kanno, Takashi Mino, Yoshio Kasashima, Masami Sakamoto
  • Journal Title: Chemistry Letters Volume: 42 Issue: 12 Pages: 1508-1510
  • DOI: 10.1246/cl.130796
  • NAID: 130004867852
  • Peer Reviewed
• [Journal Article] Deracemization of Axially Chiral Nicotinamides by Dynamic Salt Formation with Enantiopure DBTA (2013)
  • Author(s): Fumitoshi Yagishita, Norifumi Kamataki, Kazuma Okamoto, Shota Kanno, Takashi Mino, Hyuma Masu, Masami Sakamoto
  • Journal Title: Molecules Volume: 18 Issue: 11 Pages: 14430-14447
  • DOI: 10.3390/molecules181114430
  • Peer Reviewed
• [Journal Article] Copper- catalyzed asymmetric propargylic amination of propargylic acetates with amines using BICMAP (2013)
  • Author(s): Takashi Mino, Hiroyuki Taguchi, Masatoshi Hashimoto, Masami Sakamoto
  • Journal Title: Tetrahedron : Asymmetry Volume: 24 Issue: 23 Pages: 1520-1523
  • DOI: 10.1016/j.tetasy.2013.10.007
  • Peer Reviewed
• [Journal Article] Palladium-Catalyzed Mizoroki-Heck Type Reaction with Aryliodine Diacetates Using Hydrazone Ligand (2013)
  • Author(s): Takashi Mino, Kohei Watanabe, Taichi Abe, Taketo Kogure, Masami Sakamoto
  • Journal Title: Heterocycles Volume: 87 Issue: 10 Pages: 2015-2021
  • DOI: 10.3987/com-13-12786
  • Peer Reviewed
• [Journal Article] Palladium-catalyzed asymmetric allylic alkylation ofindoles by C-N bond axially chiralphosphine ligands (2013)
  • Author(s): Takashi Mino, Miho Ishikawa, Kenji Nishikawa, Kazuya Wakui, Masami Sakamoto
  • Journal Title: Tetrahedron:Asymm. Volume: Vol. 24(印刷中) Issue: 8 Pages: 499-504
  • DOI: 10.1016/j.tetasy.2013.03.008
  • Peer Reviewed
• [Journal Article] Palladium-catalyzed allylic arylation of allylic ethers with arylboronic acids using hydrazone ligands (2013)
  • Author(s): Takashi Mino, Takaehito Kogure, Taichi Abe, T. Koizumi, Tsutomu Fujita, Masami Sakamoto
  • Journal Title: European Journal of Organic Chemistry Volume: 2013 Issue: 8 Pages: 1501-1505
  • DOI: 10.1002/ejoc.201201276
  • Peer Reviewed
• [Journal Article] Photocycloaddition Reaction of Methyl 2-and 3-Chromonecarboxylates with Various Alkenes (2012)
  • Author(s): Masami Sakamoto, et al
  • Journal Title: Res. Chem. Intermed Volume: 39 Issue: 1 Pages: 385-395
  • DOI: 10.1007/s11164-012-0656-0
  • Peer Reviewed
• [Presentation] 可逆的共役付加反応によるアミノ酸誘導体の絶対不斉合成 (2016)
  • Author(s): 梶 優輝・笠嶋 義夫・吉田 泰志・三野 孝・坂本 昌巳
  • Organizer: 日本化学会第96春季年会
  • Place of Presentation: 京都
  • Year and Date: 2016-03-24
• [Presentation] チオヒダントイン誘導体の動的結晶化による不斉の制御 (2016)
  • Author(s): 上村 直弘・吉田 泰志・三野 孝・坂本 昌巳
  • Organizer: 日本化学会第96春季年会
  • Place of Presentation: 京都
  • Year and Date: 2016-03-24
• [Presentation] インデノン誘導体の光環化付加反応によるC2対称化合物の合成 (2016)
  • Author(s): 田村 尚幹・吉田 泰志・三野 孝・坂本 昌巳
  • Organizer: 日本化学会第96春季年会
  • Place of Presentation: 京都
  • Year and Date: 2016-03-24
• [Presentation] α-およびβ-アミノ酸誘導体の結晶構造解析と動的結晶化による不斉制御 (2016)
  • Author(s): 松本 有紗・吉田 泰志・笠嶋 義夫・三野 孝・坂本 昌巳
  • Organizer: 日本化学会第96春季年会
  • Place of Presentation: 京都
  • Year and Date: 2016-03-24
• [Presentation] β-アミノケトン類の結晶構造解析と動的結晶化による不斉誘導 (2016)
  • Author(s): 下林 榛菜・吉田 泰志・笠嶋 義夫・三野 孝・坂本 昌巳
  • Organizer: 日本化学会第96春季年会
  • Place of Presentation: 京都
  • Year and Date: 2016-03-24
• [Presentation] 動的結晶化を伴うα, β-不飽和アミドからのアミノ酸誘導体の不斉合成 (2016)
  • Author(s): 梶 優輝・笠嶋 義夫・吉田 泰志・三野 孝・坂本 昌巳
  • Organizer: 日本化学会第96春季年会
  • Place of Presentation: 京都
  • Year and Date: 2016-03-24
• [Presentation] 光異性化反応と動的結晶化を用いたピロリノン誘導体の絶対不斉合成 (2016)
  • Author(s): 白附 洸・吉田 泰志・三野 孝・坂本 昌巳
  • Organizer: 日本化学会第96春季年会
  • Place of Presentation: 京都
  • Year and Date: 2016-03-24
• [Presentation] Asymmetric synthesis of isoindolinones from achiral materials without an external chiral source (2015)
  • Author(s): Kohei Watanabe, Hiroki Ishikawa, Naohiro Uemura, Fumitoshi Yagishita, Takashi Mino, Masami Sakamoto
  • Organizer: Pacifichem2015
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] Asymmetric stereoisomerization of achiral 3,4-diphenylsuccinimides involving dynamic preferential crystallization (2015)
  • Author(s): Fumitoshi Yagishita, Yui Kunito, Yoshio Kasashima, Takashi Mino, Masami Sakamoto
  • Organizer: Pacifichem2015
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] Generation and amplification of chirality using organic crystals (2015)
  • Author(s): Masami Sakamoto
  • Organizer: Pacifichem2015
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2015-12-15
  • Int'l Joint Research / Invited
• [Presentation] 可逆的共役付加反応と動的優先晶出によるアミノ酸誘導体の絶対不斉合成 (2015)
  • Author(s): 梶 優輝，笠嶋 義夫，三野 孝，坂本 昌巳
  • Organizer: 2015年有機結晶シンポジウム
  • Place of Presentation: 広島
  • Year and Date: 2015-11-01
• [Presentation] 光異性化反応と動的優先晶出法を融合したピロリノン誘導体の絶対不斉合成 (2015)
  • Author(s): 白附 洸・三野 孝・坂本 昌巳
  • Organizer: 2015年有機結晶シンポジウム
  • Place of Presentation: 広島
  • Year and Date: 2015-11-01
• [Presentation] チオヒダントイン誘導体の動的結晶化による不斉の制御 (2015)
  • Author(s): 上村 直弘・三野 孝・ 坂本 昌巳
  • Organizer: 2015年有機結晶シンポジウム
  • Place of Presentation: 広島
  • Year and Date: 2015-11-01
• [Presentation] アロイルアクリルアミドの光異性化を伴うピロリノン誘導体の絶対不斉合成 (2015)
  • Author(s): 白附 洸・三野 孝・坂本昌巳
  • Organizer: CSJ FESTA 2015
  • Place of Presentation: 東京
  • Year and Date: 2015-10-13
• [Presentation] 可逆的Michael付加反応と優先晶出によるアミノ酸誘導体の絶対不斉合成 (2015)
  • Author(s): 梶 優輝・笠嶋義夫・三野 孝・坂本昌巳
  • Organizer: CSJ FESTA 2015
  • Place of Presentation: 東京
  • Year and Date: 2015-10-13
• [Presentation] 分子内光環化反応によるC2対称な大環状ポリエーテルの合成とその応用 (2015)
  • Author(s): 平良亮，帷子哲，吉田渉，三野孝，坂本昌巳
  • Organizer: 光化学討論会
  • Place of Presentation: 大阪
  • Year and Date: 2015-09-09
• [Presentation] 光異性化と動的結晶化による光学活性ピロリノン誘導体の絶対不斉合成 (2015)
  • Author(s): 白附洸，三野孝，坂本昌巳
  • Organizer: 光化学討論会
  • Place of Presentation: 大阪
  • Year and Date: 2015-09-09
• [Presentation] Asymmetric Synthesis Involving Dynamic Preferential Crystallization (2015)
  • Author(s): Masami Sakamoto
  • Organizer: ICCOSS2015
  • Place of Presentation: Niigata
  • Year and Date: 2015-07-12
  • Int'l Joint Research / Invited
• [Presentation] 光異性化反応と動的優先晶出法を利用したピロリジノン誘導体の絶対不斉合成 (2015)
  • Author(s): 白附洸，石川紘輝，三野孝，坂本昌巳
  • Organizer: モレキュラーキラリティー2015
  • Place of Presentation: 東京
  • Year and Date: 2015-06-12
• [Presentation] アミノ酸誘導体の絶対不斉合成 (2015)
  • Author(s): 梶優輝，石川紘輝，笠嶋義夫，三野孝，坂本昌巳
  • Organizer: モレキュラーキラリティー2015
  • Place of Presentation: 東京
  • Year and Date: 2015-06-12
• [Presentation] 3,4-ジフェニルスクシンイミドの固気反応による不斉発現と増幅 (2015)
  • Author(s): 國土 由衣，石川 紘輝，笠嶋 義夫，三野 孝，坂本 昌巳
  • Organizer: 日本化学会第95春期年会
  • Place of Presentation: 習志野市
  • Year and Date: 2015-03-26 – 2015-03-29
• [Presentation] 動的結晶化を伴うアミノ酸誘導体の不斉合成 (2015)
  • Author(s): 坂本 昌巳，梶 優輝，石川 紘輝，笠嶋 義夫，三野 孝
  • Organizer: 日本化学会第95春期年会
  • Place of Presentation: 習志野市
  • Year and Date: 2015-03-26 – 2015-03-29
• [Presentation] アロイルアクリルアミドの光異性化を伴う不斉の発現と増幅 (2015)
  • Author(s): 坂本 昌巳，白附 洸，道家 未央，石川 紘輝，三野 孝
  • Organizer: 日本化学会第95春期年会
  • Place of Presentation: 習志野市
  • Year and Date: 2015-03-26 – 2015-03-29
• [Presentation] ピロリジノン誘導体の動的結晶化を伴う不斉の発現と増幅 (2015)
  • Author(s): 坂本 昌巳，白附 洸，道家 未央，石川 紘輝，三野 孝
  • Organizer: 日本化学会第95春期年会
  • Place of Presentation: 習志野市
  • Year and Date: 2015-03-26 – 2015-03-29
• [Presentation] 動的優先晶出を経るアキラルな3,4-ジフェニルマレイミドからの3,4-ジフェニルスクシンイミドの不斉合成 (2015)
  • Author(s): 國土 由衣，八木下 史敏，蜂屋 祥子，笠嶋 義夫，三野 孝，坂本 昌巳
  • Organizer: 日本化学会第95春期年会
  • Place of Presentation: 習志野市
  • Year and Date: 2015-03-26 – 2015-03-29
• [Presentation] Asymmetric Synthesis Starting from Achiral Materials Involving Dynamic Preferential Crystallization (2014)
  • Author(s): Masami Sakamoto
  • Organizer: MCASIA2014
  • Place of Presentation: 北京大学
  • Year and Date: 2014-10-29 – 2014-10-31
  • Invited
• [Presentation] クロモン誘導体の光環化付加反応によるC2キラル大環状ポリエーテルの合成 (2014)
  • Author(s): 坂本 昌巳，帷子 哲，平良 亮，吉田 渉，八木下 史敏，笠嶋 義夫，三野 孝
  • Organizer: 2014光化学討論会
  • Place of Presentation: 札幌市
  • Year and Date: 2014-10-11 – 2014-10-13
• [Presentation] スクシンイミドの異性化晶出法による不斉発現と増幅 (2014)
  • Author(s): 坂本 昌巳，國土 由衣，蜂屋 祥子，八木下 史敏，笠嶋 義夫，三野 孝
  • Organizer: 有機結晶シンポジウム2014
  • Place of Presentation: 習志野市
  • Year and Date: 2014-09-15 – 2014-09-17
• [Presentation] アキラルな安息香酸誘導体からの不斉発現と増幅を伴う光学活性イソインドリノン (2014)
  • Author(s): 石川 紘輝，八木下 史敏，桝 飛雄馬，三野 孝，坂本 昌巳
  • Organizer: 有機結晶シンポジウム2014
  • Place of Presentation: 習志野市
  • Year and Date: 2014-09-15 – 2014-09-17
• [Presentation] Asymmetric Synthesis Starting from Achiral Materials Involving Dynamic Spontaneous Crystallization (2014)
  • Author(s): Masami Sakamoto
  • Organizer: IGOM11
  • Place of Presentation: 奈良
  • Year and Date: 2014-06-18 – 2014-06-24
  • Invited
• [Presentation] Asymmetric Synthesis Using Chirality of Organic Crystals (2014)
  • Author(s): Masami Sakamoto
  • Organizer: モレキュラーキラリティー2014
  • Place of Presentation: 仙台
  • Year and Date: 2014-06-06 – 2014-06-07
  • Invited
• [Presentation] クロモン誘導体の分子内光環化付加反応によるC2キラル大環状ポリエーテルの合成 (2014)
  • Author(s): 坂本昌巳, 帷子哲, 平良亮, 吉田渉, 八木下史敏, 三野孝
  • Organizer: 2014日本化学会春期年会
  • Place of Presentation: 名古屋
• [Presentation] 2-クロモンカルボン酸エステルの光二量化反応による不斉発現 (2014)
  • Author(s): 馬場望美, 八木下史敏, 三野孝, 坂本昌巳
  • Organizer: 2014日本化学会春期年会
  • Place of Presentation: 名古屋
• [Presentation] 2-クロモンカルボン酸誘導体の光二量化反応を利用したC2キラル配位子の開発 (2014)
  • Author(s): 上田祐揮, 八木下史敏, 三野孝, 坂本昌巳
  • Organizer: 2014日本化学会春期年会
  • Place of Presentation: 名古屋
• [Presentation] 動的優先晶出法を用いたイソインドリノン誘導体の不斉合成 (2014)
  • Author(s): 石川紘輝, 八木下史敏, 三野孝, 坂本昌巳
  • Organizer: 2014日本化学会春期年会
  • Place of Presentation: 名古屋
• [Presentation] スクシンイミドの動的結晶化による不斉増幅 (2014)
  • Author(s): 坂本昌巳, 國土由衣, 八木下史敏, 蜂屋祥子, 笠嶋義夫, 三野孝
  • Organizer: 2014日本化学会春期年会
  • Place of Presentation: 名古屋
• [Presentation] 2-クロモンカルボン酸エステルの光二量化による不斉発現 (2013)
  • Author(s): 坂本昌巳, 馬場望美, 八木下史敏, 三野孝
  • Organizer: 2013年度有機結晶シンポジウム
  • Place of Presentation: 札幌
• [Presentation] アキラルなスクシンイミドの結晶化による不斉発現と増幅 (2013)
  • Author(s): 坂本昌巳, 國土由衣, 蜂屋祥子, 八木下史敏, 笠嶋義夫, 三野孝
  • Organizer: 2013年度有機結晶シンポジウム
  • Place of Presentation: 札幌
• [Presentation] 2-クロモンカルボン酸エステルの分子内光環化付加反応により生成するC2キラル大環状ポリエーテルの構造解析 (2013)
  • Author(s): 坂本昌巳, 帷子哲, 吉田渉, 八木下史敏, 三野孝
  • Organizer: 2013年度有機結晶シンポジウム
  • Place of Presentation: 札幌
• [Presentation] 動的優先晶出を伴うアキラルな 2-ベンゾイル安息香酸アミドからのイソインドリノンの不斉合成 (2013)
  • Author(s): 坂本昌巳, 石川紘輝, 八木下史敏 , 笠嶋義夫, 三野孝
  • Organizer: 2013年度有機結晶シンポジウム
  • Place of Presentation: 札幌
• [Presentation] キラルな塩形成による芳香族アミド類の軸不斉制御と不斉合成への展開 (2013)
  • Author(s): 八木下史敏, 高岸尚也, 岡本一真, 桝飛雄真,三野孝, 坂本昌巳
  • Organizer: 2013年度有機結晶シンポジウム
  • Place of Presentation: 札幌
• [Presentation] 2-クロモンカルボン酸誘導体の立体選択的光二量化反応 (2013)
  • Author(s): 坂本昌巳, 馬場望美, 八木下史敏, 三野孝
  • Organizer: 2013年度光化学討論会
  • Place of Presentation: 松山
• [Presentation] クロモン誘導体の[2+2]光環化付加反応による C2キラル大環状ポリエーテルの合成 (2013)
  • Author(s): 坂本昌巳, 帷子哲, 吉田渉, 八木下史敏,三野孝
  • Organizer: 2013年度光化学討論会
  • Place of Presentation: 松山
• [Presentation] 動的結晶化を伴うアキラルな化合物からの不斉発現と増幅 (2013)
  • Author(s): 坂本昌巳, 八木下史敏, 蜂屋祥子，石川紘輝, 馬場望美, 三野孝
  • Organizer: 2013モレキュラーキラリティーシンポジウム
  • Place of Presentation: 京都
• [Presentation] 結晶化による軸不斉制御とキラルメモリーを利用した不斉合成法の開発 (2013)
  • Author(s): 八木下史敏, 高岸尚也,三野孝, 桝飛雄真,坂本昌巳
  • Organizer: 2013モレキュラーキラリティーシンポジウム
  • Place of Presentation: 京都
• [Book] Advances in Organic Crystal Chemistry: Complehensive Reviews 2015, Rui Tamura abd Mikiji Miyata eds (2015)
  • Author(s): Masami Sakamoto, Takashi Mino
  • Publisher: Springer
• [Remarks] 精密有機化学研究室
  • URL: http://chem.tf.chiba-u.jp/gacb06/nonframe_top.html
• [Remarks] 研究室ホームページ
  • URL: http://chem.tf.chiba-u.jp/gacb06/index.html