New Synthetic Methods based on Fine Control with Iron Catalysts
Project/Area Number |
25288018
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Organic chemistry
|
Research Institution | Tokyo Institute of Technology |
Principal Investigator |
URABE HIROKAZU 東京工業大学, 生命理工学研究科, 教授 (10176745)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2013: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
|
Keywords | 共役付加反応 / グリニャール試薬 / 炭素―炭素多重結合 / 置換反応 / 低原子価鉄錯体 / 鉄塩 / 鉄触媒 / ハロゲン/メタル交換 / 共役付加 |
Outline of Final Research Achievements |
This study reveals the following new synthetic reactions with iron catalysts (or reagents) and aryl Grignard reagents: addition of heterocycles to dienoates and related compounds / addition to dienylphosphine oxides / addition to dienylphosphonates / addition to substituted dienoates and related compounds / addition of aliphatic Grignard reagents to dienoates and related compounds / addition to ω-iododienoates and related compounds followed by cyclization / addition to enynoates and its application to a synthesis of meloscine / a 3-component coupling with enynoates and organic halides / preparation of cyclopropanes from ω-iododienoates, ω-iodoenoates, and related compounds / alkylation of pyridines at their 4-positions / synthetic study of zincophorin from functionalized diene monoepoxides / preparation of amines from nitro compounds / preparation of nitrones from nitro compounds, CeCl3, and CuF.
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Report
(4 results)
Research Products
(15 results)